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Items: 1 to 20 of 90

1.

Dimethylaminopyridine derivatives of lupane triterpenoids are potent disruptors of mitochondrial structure and function.

Holy J, Kolomitsyna O, Krasutsky D, Oliveira PJ, Perkins E, Krasutsky PA.

Bioorg Med Chem. 2010 Aug 15;18(16):6080-8. doi: 10.1016/j.bmc.2010.06.075. Epub 2010 Jul 1.

PMID:
20673631
2.

Dimethylaminopyridine derivatives of lupane triterpenoids cause mitochondrial disruption and induce the permeability transition.

Bernardo TC, Cunha-Oliveira T, Serafim TL, Holy J, Krasutsky D, Kolomitsyna O, Krasutsky P, Moreno AM, Oliveira PJ.

Bioorg Med Chem. 2013 Dec 1;21(23):7239-49. doi: 10.1016/j.bmc.2013.09.066. Epub 2013 Oct 8.

PMID:
24156937
3.

New derivatives of lupane triterpenoids disturb breast cancer mitochondria and induce cell death.

Serafim TL, Carvalho FS, Bernardo TC, Pereira GC, Perkins E, Holy J, Krasutsky DA, Kolomitsyna ON, Krasutsky PA, Oliveira PJ.

Bioorg Med Chem. 2014 Nov 1;22(21):6270-87. doi: 10.1016/j.bmc.2014.08.013. Epub 2014 Sep 6.

PMID:
25245673
4.

[Biological activity and pharmacological prospects of lupane terpenoids: I. Natural lupane derivatives].

Tolstikova TG, Sorokina IV, Tolstikov GA, Tolstikov AG, Flekhter OB.

Bioorg Khim. 2006 Jan-Feb;32(1):42-55. Review. Russian.

PMID:
16523720
5.

Apoptotic activity of betulinic acid derivatives on murine melanoma B16 cell line.

Liu WK, Ho JC, Cheung FW, Liu BP, Ye WC, Che CT.

Eur J Pharmacol. 2004 Sep 13;498(1-3):71-8.

PMID:
15363977
6.

Synthesis, proapoptotic screening, and structure-activity relationships of novel aza-lupane triterpenoids.

Mar AA, Szotek EL, Koohang A, Flavin WP, Eiznhamer DA, Flavin MT, Xu ZQ.

Bioorg Med Chem Lett. 2010 Sep 15;20(18):5389-93. doi: 10.1016/j.bmcl.2010.07.120. Epub 2010 Aug 3.

PMID:
20719505
7.

Antitumor-promoting effects and cytotoxic activities of dammar resin triterpenoids and their derivatives.

Ukiya M, Kikuchi T, Tokuda H, Tabata K, Kimura Y, Arai T, Ezaki Y, Oseto O, Suzuki T, Akihisa T.

Chem Biodivers. 2010 Aug;7(8):1871-84. doi: 10.1002/cbdv.201000107.

PMID:
20730953
8.

Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax-triggered mitochondrial pathway.

Hsieh YC, Rao YK, Wu CC, Huang CY, Geethangili M, Hsu SL, Tzeng YM.

Chem Res Toxicol. 2010 Jul 19;23(7):1256-67. doi: 10.1021/tx100116a.

PMID:
20557081
9.

New cytotoxic rosamine derivatives selectively accumulate in the mitochondria of cancer cells.

Lim SH, Wu L, Burgess K, Lee HB.

Anticancer Drugs. 2009 Jul;20(6):461-8. doi: 10.1097/CAD.0b013e32832b7bee.

PMID:
19387338
10.

Maslinic acid derivatives induce significant apoptosis in b16f10 murine melanoma cells.

Parra A, Rivas F, Martin-Fonseca S, Garcia-Granados A, Martinez A.

Eur J Med Chem. 2011 Dec;46(12):5991-6001. doi: 10.1016/j.ejmech.2011.10.011. Epub 2011 Oct 12.

PMID:
22019227
11.

New lupane derived compounds with pro-apoptotic activity in cancer cells: synthesis and structure-activity relationships.

Sarek J, Klinot J, Dzubák P, Klinotová E, Nosková V, Krecek V, Korínková G, Thomson JO, Janost'áková A, Wang S, Parsons S, Fischer PM, Zhelev NZ, Hajdúch M.

J Med Chem. 2003 Dec 4;46(25):5402-15.

PMID:
14640549
12.

Corchorusin-D, a saikosaponin-like compound isolated from Corchorus acutangulus Lam., targets mitochondrial apoptotic pathways in leukemic cell lines (HL-60 and U937).

Mallick S, Ghosh P, Samanta SK, Kinra S, Pal BC, Gomes A, Vedasiromoni JR.

Cancer Chemother Pharmacol. 2010 Sep;66(4):709-19. doi: 10.1007/s00280-009-1214-3. Epub 2009 Dec 24.

PMID:
20033811
13.

A flavivirus protein M-derived peptide directly permeabilizes mitochondrial membranes, triggers cell death and reduces human tumor growth in nude mice.

Brabant M, Baux L, Casimir R, Briand JP, Chaloin O, Porceddu M, Buron N, Chauvier D, Lassalle M, Lecoeur H, Langonné A, Dupont S, Déas O, Brenner C, Rebouillat D, Muller S, Borgne-Sanchez A, Jacotot E.

Apoptosis. 2009 Oct;14(10):1190-203. doi: 10.1007/s10495-009-0394-y.

PMID:
19693674
14.

Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade.

Tang XL, Yang XY, Jung HJ, Kim SY, Jung SY, Choi DY, Park WC, Park H.

Biol Pharm Bull. 2009 Aug;32(8):1399-405.

15.

Small structural changes of pentacyclic lupane type triterpenoid derivatives lead to significant differences in their anticancer properties.

Kommera H, Kaluderović GN, Kalbitz J, Dräger B, Paschke R.

Eur J Med Chem. 2010 Aug;45(8):3346-53. doi: 10.1016/j.ejmech.2010.04.018. Epub 2010 Apr 27.

PMID:
20472329
16.

Mitochondria-Targeted Lupane Triterpenoid Derivatives and Their Selective Apoptosis-Inducing Anticancer Mechanisms.

Ye Y, Zhang T, Yuan H, Li D, Lou H, Fan P.

J Med Chem. 2017 Jul 27;60(14):6353-6363. doi: 10.1021/acs.jmedchem.7b00679. Epub 2017 Jul 18.

PMID:
28671831
17.

Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.

Pereira GC, Branco AF, Matos JA, Pereira SL, Parke D, Perkins EL, Serafim TL, Sardão VA, Santos MS, Moreno AJ, Holy J, Oliveira PJ.

J Pharmacol Exp Ther. 2007 Nov;323(2):636-49. Epub 2007 Aug 17.

18.

Alkylidene branched lupane derivatives: synthesis and antitumor activity.

Csuk R, Stark S, Nitsche C, Barthel A, Siewert B.

Eur J Med Chem. 2012 Jul;53:337-45. doi: 10.1016/j.ejmech.2012.04.023. Epub 2012 Apr 25.

PMID:
22578785
19.

Isocostunolide, a sesquiterpene lactone, induces mitochondrial membrane depolarization and caspase-dependent apoptosis in human melanoma cells.

Chen CN, Huang HH, Wu CL, Lin CP, Hsu JT, Hsieh HP, Chuang SE, Lai GM.

Cancer Lett. 2007 Feb 8;246(1-2):237-52. Epub 2006 May 11.

PMID:
16697106
20.

Maslinic acid, a natural triterpene from Olea europaea L., induces apoptosis in HT29 human colon-cancer cells via the mitochondrial apoptotic pathway.

Reyes-Zurita FJ, Rufino-Palomares EE, Lupiáñez JA, Cascante M.

Cancer Lett. 2009 Jan 8;273(1):44-54. doi: 10.1016/j.canlet.2008.07.033. Epub 2008 Sep 14.

PMID:
18790561

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