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20658586,20658585,16990386,31258525,17989688,21222185,14762182,19399743,16464755,27644115,17405753,26333021,26690023,28629435,21561403,24331206,33730455,22169380,30510079,21145109,22350448,19074068,24168416,23402025,28748287,18784156,20035691,17702897,16491626,21082989,17925885,26352814,22964233,33301613,25477495,20145265,20230403,31379839,23617322,33249943,29383624,16926130,24777716,22767128,23934275,19144399,25468487,33464651,25468724,18055865,31978221,34973099,33512400,31840801,22542362,23917586,23738544,21296371,22395662,21883481,26839475,26689746,23271156,20151973,30510080,26043392,32449174,21611719,32856539,33765419,15985537,17852463,32011183,35068377,30711779,19954846,29486674,18756538,22077430,22981033,25971274,18503589,30708188,20081060,36750531,21460245,32311169,29314145,26043387,26792457,25186487,20068220,34314483,20603032,30032748,32856141,27464489,26143713,32886668,19833423,22197277,30032749,36459381,24370061,19372253,19705437,28610663,25034232,18578555,35502699,18063459,33341510,24489894,26124968,17549742,35390189,25868955,22160008,22989836,25757938,30193519,36775313,30159857,17408457,26895645,26990688,18654116,18801601,22085388,32917848,18952283,25688464,36532073,30171081,34108318,23657069,31662004,33356783,31171752,25497169,26857155,26251141,33902068,35491057,28028023,29898960,21121856,25296873,21597283,26486669,35502600,19179465,19224425,21655680,20232400,30367826,24429452,32945525,36108594,30768680,26830487,28646725,19231766,26251149,28608499,35146630,31068556,33844861,16995344,32202389,33006965,22566286,36594182,21110191,30418552,20818912,28692147,36732204,30504334,36117056,18714106,22237246,21253430,25634611,23046169,34482398,35699586,33346448,21457219,34445916,31949012,27194791,30032754,21929681,22206707,19450749,35078384,35049058,30055352,27501352,26337866,28328837,23747093,32624532,32495372,25937178,20068274,32542443,26316621,34191092,34544179,32640047,20445192,28124080,33170342,35699625,36811247,24534107,34275086,33780028,35869170,19074053,23752125,36794458,22080148,32519233,32869125,17193722,31916226,32908057,24521109,33047216,26366354,25765788,35923770,36626252,17878890,29973448,31277120,30569992,21108715,31703946,22571809,28439081,21623921,29043236,17076159,22415067,17195305,27873177,20553271,20445191,25501409,34011023,33178408,25402185,36398537,5935361,29021487,35980222,24497537,31750542,23486421,19179328,22372429,15507422,17195307,31534662,36286943,21375975,27598771,25651368,27536121,21692905,19538160,36660902,35663504,22354668,35491214,31446305,24762722,7448417,22739575,23210433,35830642,29102415,29676447,31622197,31502726,24602464,22696664,17192547,20378572,32582144,25530108,24758317,29138283,28437723,33121236,31256219,15105233,30767127,29551496,18413620,33945618,26111482,34899761,23610373,21897069,24924752,34342834,25581812,2593321,26341313,26141243,9034290,30194314,17372586,26472567,35441351,30126686,20011245,34800310,18368508,36161656,29323198,35806224,32357555,27472742,27509843,29212979,23512355,35988306,1179424,11157403,30909646,33894850,29545341,27401544,36688486,27449072,17715500,33460089,34398258,29527312,26171282,35869984,22231749,32218584,33560079,22435383,22435384,22413827,32624359,2604452,31171755,23636668,29649283,32845970,31492725,30381527,27234741,22197600,28622911,37079521,33398182,19836075,1879240,35561315,24701978,24458177,7211483,35316499,24666503,17522699,26034803,35709087,27497837,22760926,31543153,1142529,23465757,30767274,9870507,29435915,20440280,24364276,5478065,34296421,36394176,27568864,20739770,35608260,24455465,28045484,21465187,21335395,31671376,23756354,27018802,32602752,33480648,27371974,31355021,19179329,4473995,24677397,17468139,26267719,31120547,32948059,32384086,26022031,35535299,8107942,34796912,30147909,33512711,24132114,24566955,22243955,17249850,2938813,28808592,32191798,22551888,18575046,33256385,35497647,22009616,19439754,12819326,19372265,30214768,17552341,12752894,4859688,24382084,21358661,17989689,25949344,31209353,28434706,28355403,23402026,7001051,3189425,16138042,26837283,1490450,16582708,24577730,26491580,34176843,29980910,9812562,34622110[uid]

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Long-term effect of the complement inhibitor eculizumab on kidney function in patients with paroxysmal nocturnal hemoglobinuria.

Hillmen P, Elebute M, Kelly R, Urbano-Ispizua A, Hill A, Rother RP, Khursigara G, Fu CL, Omine M, Browne P, Rosse W. Hillmen P, et al. Am J Hematol. 2010 Aug;85(8):553-9. doi: 10.1002/ajh.21757. Am J Hematol. 2010. PMID: 20658586 Free article. Clinical Trial.

Improving renal outcomes in chronic anemia: learning from paroxysmal nocturnal hemoglobinuria.

Guasch A. Guasch A. Am J Hematol. 2010 Aug;85(8):551-2. doi: 10.1002/ajh.21800. Am J Hematol. 2010. PMID: 20658585 Free article. No abstract available.

The complement inhibitor eculizumab in paroxysmal nocturnal hemoglobinuria.

Hillmen P, Young NS, Schubert J, Brodsky RA, Socié G, Muus P, Röth A, Szer J, Elebute MO, Nakamura R, Browne P, Risitano AM, Hill A, Schrezenmeier H, Fu CL, Maciejewski J, Rollins SA, Mojcik CF, Rother RP, Luzzatto L. Hillmen P, et al. N Engl J Med. 2006 Sep 21;355(12):1233-43. doi: 10.1056/NEJMoa061648. N Engl J Med. 2006. PMID: 16990386 Free article. Clinical Trial.

Anti-complement Treatment for Paroxysmal Nocturnal Hemoglobinuria: Time for Proximal Complement Inhibition? A Position Paper From the SAAWP of the EBMT.

Risitano AM, Marotta S, Ricci P, Marano L, Frieri C, Cacace F, Sica M, Kulasekararaj A, Calado RT, Scheinberg P, Notaro R, Peffault de Latour R. Risitano AM, et al. Front Immunol. 2019 Jun 14;10:1157. doi: 10.3389/fimmu.2019.01157. eCollection 2019. Front Immunol. 2019. PMID: 31258525 Free PMC article. Review.

Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria.

Rother RP, Rollins SA, Mojcik CF, Brodsky RA, Bell L. Rother RP, et al. Nat Biotechnol. 2007 Nov;25(11):1256-64. doi: 10.1038/nbt1344. Nat Biotechnol. 2007. PMID: 17989688

Safety and efficacy of the terminal complement inhibitor eculizumab in Japanese patients with paroxysmal nocturnal hemoglobinuria: the AEGIS clinical trial.

Kanakura Y, Ohyashiki K, Shichishima T, Okamoto S, Ando K, Ninomiya H, Kawaguchi T, Nakao S, Nakakuma H, Nishimura J, Kinoshita T, Bedrosian CL, Valentine ME, Khursigara G, Ozawa K, Omine M. Kanakura Y, et al. Int J Hematol. 2011 Jan;93(1):36-46. doi: 10.1007/s12185-010-0748-9. Epub 2011 Jan 12. Int J Hematol. 2011. PMID: 21222185 Clinical Trial.

Effect of eculizumab on hemolysis and transfusion requirements in patients with paroxysmal nocturnal hemoglobinuria.

Hillmen P, Hall C, Marsh JC, Elebute M, Bombara MP, Petro BE, Cullen MJ, Richards SJ, Rollins SA, Mojcik CF, Rother RP. Hillmen P, et al. N Engl J Med. 2004 Feb 5;350(6):552-9. doi: 10.1056/NEJMoa031688. N Engl J Med. 2004. PMID: 14762182 Free article. Clinical Trial.

Successful liver transplantation for Budd-Chiari syndrome in a patient with paroxysmal nocturnal hemoglobinuria treated with the anti-complement antibody eculizumab.

Singer AL, Locke JE, Stewart ZA, Lonze BE, Hamilton JP, Scudiere JR, Anders RA, Rother RP, Brodsky RA, Cameron AM. Singer AL, et al. Liver Transpl. 2009 May;15(5):540-3. doi: 10.1002/lt.21714. Liver Transpl. 2009. PMID: 19399743 Free article.

Improvement in the symptoms of smooth muscle dystonia during eculizumab therapy in paroxysmal nocturnal hemoglobinuria.

Hill A, Rother RP, Hillmen P. Hill A, et al. Haematologica. 2005 Dec;90(12 Suppl):ECR40. Haematologica. 2005. PMID: 16464755

Extravascular hemolysis and complement consumption in Paroxysmal Nocturnal Hemoglobinuria patients undergoing eculizumab treatment.

Subías Hidalgo M, Martin Merinero H, López A, Anter J, García SP, Ataúlfo Gonzalez-Fernández F, Forés R, Lopez-Trascasa M, Villegas A, Ojeda E, Rodríguez de Córdoba S. Subías Hidalgo M, et al. Immunobiology. 2017 Feb;222(2):363-371. doi: 10.1016/j.imbio.2016.09.002. Epub 2016 Sep 13. Immunobiology. 2017. PMID: 27644115 Free article.

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