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Items: 1 to 20 of 118

1.

Experiences with learning and confirming in drug and biological development.

Patterson SD.

Clin Pharmacol Ther. 2010 Aug;88(2):161-3. doi: 10.1038/clpt.2010.50. Review.

PMID:
20648033
2.

ASCPT Task Force for advancing pharmacometrics and integration into drug development.

Goldberger MJ, Singh N, Allerheiligen S, Gobburu JV, Lalonde R, Smith B, Ryder S, Yozviak A.

Clin Pharmacol Ther. 2010 Aug;88(2):158-61. doi: 10.1038/clpt.2010.141. Review. Erratum in: Clin Pharmacol Ther. 2010 Dec;88(6):883.. Allerheiligan, S [corrected to Allerheiligen, S].

PMID:
20648032
3.

Next-generation model-based drug discovery and development: quantitative and systems pharmacology.

Allerheiligen SR.

Clin Pharmacol Ther. 2010 Jul;88(1):135-7. doi: 10.1038/clpt.2010.81. Epub 2010 Jun 9. Review.

PMID:
20531467
4.

Biostatistics and pharmacometrics: quantitative sciences to propel drug development forward.

Smith BP, Vincent J.

Clin Pharmacol Ther. 2010 Aug;88(2):141-4. doi: 10.1038/clpt.2010.136. No abstract available.

PMID:
20648027
5.

Drug research: from the idea to the product.

Kuhlmann J.

Int J Clin Pharmacol Ther. 1997 Dec;35(12):541-52. Review.

PMID:
9455711
6.

[Role of pharmacokinetic-pharmacodynamic relationships in drug development].

Bellissant E, Courcier-Duplantier S, Blin O; Giens XVII.

Therapie. 2002 Jul-Aug;57(4):347-57. French.

PMID:
12422555
7.

Innovative approaches in drug development.

Chang M, Kenley S, Bull J, Chiu YY, Wang W, Wakeford C, McCarthy K.

J Biopharm Stat. 2007;17(5):775-89. Review.

PMID:
17885865
8.

The Rheumatoid Arthritis Drug Development Model: a case study in Bayesian clinical trial simulation.

Nixon RM, O'Hagan A, Oakley J, Madan J, Stevens JW, Bansback N, Brennan A.

Pharm Stat. 2009 Oct-Dec;8(4):371-89. doi: 10.1002/pst.368.

PMID:
19340851
9.

Alternative strategies in drug development: clinical pharmacological aspects.

Kuhlmann J.

Int J Clin Pharmacol Ther. 1999 Dec;37(12):575-83. Review.

PMID:
10599949
10.

Pharmacokinetics/pharmacodynamics in drug development: an industrial perspective.

Chaikin P, Rhodes GR, Bruno R, Rohatagi S, Natarajan C.

J Clin Pharmacol. 2000 Dec;40(12 Pt 2):1428-38. Review.

PMID:
11185663
11.

Clinical trial simulation: a review.

Holford N, Ma SC, Ploeger BA.

Clin Pharmacol Ther. 2010 Aug;88(2):166-82. doi: 10.1038/clpt.2010.114. Epub 2010 Jul 7. Review.

PMID:
20613720
12.

Confirmatory seamless phase II/III clinical trials with hypotheses selection at interim: general concepts.

Bretz F, Schmidli H, König F, Racine A, Maurer W.

Biom J. 2006 Aug;48(4):623-34.

PMID:
16972714
13.

The use of mechanistic biomarkers for evaluating investigational CNS compounds in early drug development.

Soares HD.

Curr Opin Investig Drugs. 2010 Jul;11(7):795-801. Review.

PMID:
20571975
14.

A comparison of methods for adaptive treatment selection.

Friede T, Stallard N.

Biom J. 2008 Oct;50(5):767-81. doi: 10.1002/bimj.200710453.

PMID:
18932136
15.

Understanding pharmacology in humans: Phase I and Phase II (data generation).

Merlo Pich E.

Curr Opin Pharmacol. 2011 Oct;11(5):557-62. doi: 10.1016/j.coph.2011.06.010. Epub 2011 Jul 21. Review.

PMID:
21783419
16.

Role of modelling and simulation in Phase I drug development.

Aarons L, Karlsson MO, Mentré F, Rombout F, Steimer JL, van Peer A; COST B15 Experts.

Eur J Pharm Sci. 2001 May;13(2):115-22. Review.

PMID:
11297895
17.

Integration of pharmacokinetic and pharmacodynamic studies in the discovery, development, and review of protein therapeutic agents: a conference report.

Galluppi GR, Rogge MC, Roskos LK, Lesko LJ, Green MD, Feigal DW Jr, Peck CC.

Clin Pharmacol Ther. 2001 Jun;69(6):387-99. No abstract available.

PMID:
11406736
18.

Failure is an option: learning from unsuccessful proof-of-concept trials.

Schäfer S, Kolkhof P.

Drug Discov Today. 2008 Nov;13(21-22):913-6. doi: 10.1016/j.drudis.2008.03.026. Epub 2008 Jun 17. Review.

PMID:
18954804
19.

Multiscale modeling in drug discovery and development: future opportunities and present challenges.

Vicini P.

Clin Pharmacol Ther. 2010 Jul;88(1):126-9. doi: 10.1038/clpt.2010.87. Epub 2010 Jun 2. Review.

PMID:
20520608
20.

A 25-year review of sequential methodology in clinical studies.

Todd S.

Stat Med. 2007 Jan 30;26(2):237-52. Review.

PMID:
17139691

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