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Items: 1 to 20 of 103

1.

Recovery and purification process development for monoclonal antibody production.

Liu HF, Ma J, Winter C, Bayer R.

MAbs. 2010 Sep-Oct;2(5):480-99. Epub 2010 Sep 1. Review.

2.

Caprylic acid-induced impurity precipitation from protein A capture column elution pool to enable a two-chromatography-step process for monoclonal antibody purification.

Zheng J, Wang L, Twarowska B, Laino S, Sparks C, Smith T, Russell R, Wang M.

Biotechnol Prog. 2015 Nov-Dec;31(6):1515-25. doi: 10.1002/btpr.2154. Epub 2015 Sep 4.

PMID:
26280674
3.

Development of a novel and efficient cell culture flocculation process using a stimulus responsive polymer to streamline antibody purification processes.

Kang YK, Hamzik J, Felo M, Qi B, Lee J, Ng S, Liebisch G, Shanehsaz B, Singh N, Persaud K, Ludwig DL, Balderes P.

Biotechnol Bioeng. 2013 Nov;110(11):2928-37. doi: 10.1002/bit.24969. Epub 2013 Jun 29.

4.

Using partition designs to enhance purification process understanding.

Pieracci J, Perry L, Conley L.

Biotechnol Bioeng. 2010 Dec 1;107(5):814-24. doi: 10.1002/bit.22866.

PMID:
20632374
5.

A new, integrated, continuous purification process template for monoclonal antibodies: Process modeling and cost of goods studies.

Xenopoulos A.

J Biotechnol. 2015 Nov 10;213:42-53. doi: 10.1016/j.jbiotec.2015.04.020. Epub 2015 May 8.

PMID:
25959171
6.

PDADMAC flocculation of Chinese hamster ovary cells: enabling a centrifuge-less harvest process for monoclonal antibodies.

McNerney T, Thomas A, Senczuk A, Petty K, Zhao X, Piper R, Carvalho J, Hammond M, Sawant S, Bussiere J.

MAbs. 2015;7(2):413-28. doi: 10.1080/19420862.2015.1007824.

7.

Affinity-based precipitation via a bivalent peptidic hapten for the purification of monoclonal antibodies.

Handlogten MW, Stefanick JF, Deak PE, Bilgicer B.

Analyst. 2014 Sep 7;139(17):4247-55. doi: 10.1039/c4an00780h.

PMID:
25006715
8.

[Alternative production systems for therapeutic monoclonal antibodies].

Olivier S, Mehtali M.

Med Sci (Paris). 2009 Dec;25(12):1163-8. doi: 10.1051/medsci/200925121163. Review. French. No abstract available.

9.

A simple and efficient purification platform for monoclonal antibody production based on chromatin-directed cell culture clarification integrated with precipitation and void-exclusion anion exchange chromatography.

Chen Q, Abdul Latiff SM, Toh P, Peng X, Hoi A, Xian M, Zhang H, Nian R, Zhang W, Gagnon P.

J Biotechnol. 2016 Oct 20;236:128-40. doi: 10.1016/j.jbiotec.2016.08.014. Epub 2016 Aug 25.

PMID:
27568167
10.

Designing new monoclonal antibody purification processes using mixed-mode chromatography sorbents.

Toueille M, Uzel A, Depoisier JF, Gantier R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Apr 15;879(13-14):836-43. doi: 10.1016/j.jchromb.2011.02.047. Epub 2011 Mar 23.

PMID:
21439915
11.

Using precipitation by polyamines as an alternative to chromatographic separation in antibody purification processes.

Ma J, Hoang H, Myint T, Peram T, Fahrner R, Chou JH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Mar 15;878(9-10):798-806. doi: 10.1016/j.jchromb.2010.01.044. Epub 2010 Feb 4.

PMID:
20181538
12.

Comparison of standard and new generation hydrophobic interaction chromatography resins in the monoclonal antibody purification process.

Chen J, Tetrault J, Ley A.

J Chromatogr A. 2008 Jan 11;1177(2):272-81. Epub 2007 Aug 7.

PMID:
17709111
13.

Comprehensive tracking of host cell proteins during monoclonal antibody purifications using mass spectrometry.

Zhang Q, Goetze AM, Cui H, Wylie J, Trimble S, Hewig A, Flynn GC.

MAbs. 2014 May-Jun;6(3):659-70. doi: 10.4161/mabs.28120. Epub 2014 Feb 11.

14.

Purification of antibodies by precipitating impurities using Polyethylene Glycol to enable a two chromatography step process.

Giese G, Myrold A, Gorrell J, Persson J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Nov 1;938:14-21. doi: 10.1016/j.jchromb.2013.08.029. Epub 2013 Aug 28.

PMID:
24036248
15.

Advective hydrogel membrane chromatography for monoclonal antibody purification in bioprocessing.

Hou Y, Brower M, Pollard D, Kanani D, Jacquemart R, Kachuik B, Stout J.

Biotechnol Prog. 2015 Jul-Aug;31(4):974-82. doi: 10.1002/btpr.2113. Epub 2015 Jun 14.

PMID:
26018631
16.

Large-scale monoclonal antibody purification by continuous chromatography, from process design to scale-up.

Girard V, Hilbold NJ, Ng CK, Pegon L, Chahim W, Rousset F, Monchois V.

J Biotechnol. 2015 Nov 10;213:65-73. doi: 10.1016/j.jbiotec.2015.04.026. Epub 2015 May 8.

PMID:
25962790
17.

2-D DIGE to expedite downstream process development for human monoclonal antibody purification.

Grzeskowiak JK, Tscheliessnig A, Toh PC, Chusainow J, Lee YY, Wong N, Jungbauer A.

Protein Expr Purif. 2009 Jul;66(1):58-65.

PMID:
19367714
18.

High-throughput mAb expression and purification platform based on transient CHO.

Barnard GC, Hougland MD, Rajendra Y.

Biotechnol Prog. 2015 Jan-Feb;31(1):239-47. doi: 10.1002/btpr.2012. Epub 2014 Nov 28.

PMID:
25403790
19.

Fast and scalable purification of a therapeutic full-length antibody based on process crystallization.

Smejkal B, Agrawal NJ, Helk B, Schulz H, Giffard M, Mechelke M, Ortner F, Heckmeier P, Trout BL, Hekmat D.

Biotechnol Bioeng. 2013 Sep;110(9):2452-61. doi: 10.1002/bit.24908. Epub 2013 Apr 22.

PMID:
23532914
20.

Design of a filter train for precipitate removal in monoclonal antibody downstream processing.

Kandula S, Babu S, Jin M, Shukla AA.

Biotechnol Appl Biochem. 2009 Oct 1;54(3):149-55. doi: 10.1042/BA20090181.

PMID:
19656082

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