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Items: 1 to 20 of 71

1.

Deoxygedunin, a natural product with potent neurotrophic activity in mice.

Jang SW, Liu X, Chan CB, France SA, Sayeed I, Tang W, Lin X, Xiao G, Andero R, Chang Q, Ressler KJ, Ye K.

PLoS One. 2010 Jul 13;5(7):e11528. doi: 10.1371/journal.pone.0011528.

2.

Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents.

Nie S, Xu Y, Chen G, Ma K, Han C, Guo Z, Zhang Z, Ye K, Cao X.

Neuropharmacology. 2015 Dec;99:448-58. doi: 10.1016/j.neuropharm.2015.08.016. Epub 2015 Aug 14.

PMID:
26282118
3.

A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone.

Jang SW, Liu X, Yepes M, Shepherd KR, Miller GW, Liu Y, Wilson WD, Xiao G, Blanchi B, Sun YE, Ye K.

Proc Natl Acad Sci U S A. 2010 Feb 9;107(6):2687-92. doi: 10.1073/pnas.0913572107. Epub 2010 Jan 25.

4.

N-acetylserotonin activates TrkB receptor in a circadian rhythm.

Jang SW, Liu X, Pradoldej S, Tosini G, Chang Q, Iuvone PM, Ye K.

Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3876-81. doi: 10.1073/pnas.0912531107. Epub 2010 Feb 4.

5.

Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.

Massa SM, Yang T, Xie Y, Shi J, Bilgen M, Joyce JN, Nehama D, Rajadas J, Longo FM.

J Clin Invest. 2010 May;120(5):1774-85. doi: 10.1172/JCI41356. Epub 2010 Apr 19.

6.

Biochemical and biophysical investigation of the brain-derived neurotrophic factor mimetic 7,8-dihydroxyflavone in the binding and activation of the TrkB receptor.

Liu X, Obianyo O, Chan CB, Huang J, Xue S, Yang JJ, Zeng F, Goodman M, Ye K.

J Biol Chem. 2014 Oct 3;289(40):27571-84. doi: 10.1074/jbc.M114.562561. Epub 2014 Aug 20.

7.

N-acetylserotonin: circadian activation of the BDNF receptor and neuroprotection in the retina and brain.

Iuvone PM, Boatright JH, Tosini G, Ye K.

Adv Exp Med Biol. 2014;801:765-71. doi: 10.1007/978-1-4614-3209-8_96.

8.

O-methylated metabolite of 7,8-dihydroxyflavone activates TrkB receptor and displays antidepressant activity.

Liu X, Qi Q, Xiao G, Li J, Luo HR, Ye K.

Pharmacology. 2013;91(3-4):185-200. doi: 10.1159/000346920. Epub 2013 Feb 21.

9.

Neuroprotective effects of reactive oxygen species mediated by BDNF-independent activation of TrkB.

Huang YZ, McNamara JO.

J Neurosci. 2012 Oct 31;32(44):15521-32. doi: 10.1523/JNEUROSCI.0755-12.2012.

10.

Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB.

Wang R, Li YB, Li YH, Xu Y, Wu HL, Li XJ.

Brain Res. 2008 May 19;1210:84-91. doi: 10.1016/j.brainres.2008.01.104. Epub 2008 Apr 16.

PMID:
18420184
11.
12.

Brain-derived neurotrophic factor reduces cortical cell death by ischemia after middle cerebral artery occlusion in the rat.

Ferrer I, Krupinski J, Goutan E, Martí E, Ambrosio S, Arenas E.

Acta Neuropathol. 2001 Mar;101(3):229-38.

PMID:
11307622
14.

The novel squamosamide derivative FLZ enhances BDNF/TrkB/CREB signaling and inhibits neuronal apoptosis in APP/PS1 mice.

Li N, Liu GT.

Acta Pharmacol Sin. 2010 Mar;31(3):265-72. doi: 10.1038/aps.2010.3. Epub 2010 Feb 15.

15.

Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo.

Helgager J, Huang YZ, Mcnamara JO.

J Comp Neurol. 2014 Dec 1;522(17):3885-99. doi: 10.1002/cne.23647. Epub 2014 Aug 25.

16.

Small-molecule trkB agonists promote axon regeneration in cut peripheral nerves.

English AW, Liu K, Nicolini JM, Mulligan AM, Ye K.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16217-22. doi: 10.1073/pnas.1303646110. Epub 2013 Sep 16.

17.

Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures.

Cardenas-Aguayo Mdel C, Kazim SF, Grundke-Iqbal I, Iqbal K.

PLoS One. 2013;8(1):e53596. doi: 10.1371/journal.pone.0053596. Epub 2013 Jan 8.

18.
20.

Cystamine prevents haloperidol-induced decrease of BDNF/TrkB signaling in mouse frontal cortex.

Pillai A, Veeranan-Karmegam R, Dhandapani KM, Mahadik SP.

J Neurochem. 2008 Nov;107(4):941-51. doi: 10.1111/j.1471-4159.2008.05665.x. Epub 2008 Sep 11.

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