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Items: 1 to 20 of 103

1.

Ligand binding shuttles thrombin along a continuum of zymogen- and proteinase-like states.

Kamath P, Huntington JA, Krishnaswamy S.

J Biol Chem. 2010 Sep 10;285(37):28651-8. doi: 10.1074/jbc.M110.154914. Epub 2010 Jul 16.

2.

The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase.

Bradford HN, Krishnaswamy S.

J Biol Chem. 2016 May 20;291(21):11114-23. doi: 10.1074/jbc.M116.723072. Epub 2016 Mar 24.

3.

Meizothrombin is an unexpectedly zymogen-like variant of thrombin.

Bradford HN, Krishnaswamy S.

J Biol Chem. 2012 Aug 31;287(36):30414-25. doi: 10.1074/jbc.M112.394809. Epub 2012 Jul 19.

4.

The transition of prothrombin to thrombin.

Krishnaswamy S.

J Thromb Haemost. 2013 Jun;11 Suppl 1:265-76. doi: 10.1111/jth.12217. Review.

5.

Expression of allosteric linkage between the sodium ion binding site and exosite I of thrombin during prothrombin activation.

Kroh HK, Tans G, Nicolaes GA, Rosing J, Bock PE.

J Biol Chem. 2007 Jun 1;282(22):16095-104. Epub 2007 Apr 12.

6.

Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase.

Bianchini EP, Orcutt SJ, Panizzi P, Bock PE, Krishnaswamy S.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10099-104. Epub 2005 Jul 8.

7.

Binding of exosite ligands to human thrombin. Re-evaluation of allosteric linkage between thrombin exosites I and II.

Verhamme IM, Olson ST, Tollefsen DM, Bock PE.

J Biol Chem. 2002 Mar 1;277(9):6788-98. Epub 2001 Nov 27.

8.
9.

Autoactivation of thrombin precursors.

Pozzi N, Chen Z, Zapata F, Niu W, Barranco-Medina S, Pelc LA, Di Cera E.

J Biol Chem. 2013 Apr 19;288(16):11601-10. doi: 10.1074/jbc.M113.451542. Epub 2013 Mar 6.

10.

An ensemble view of thrombin allostery.

Lechtenberg BC, Freund SM, Huntington JA.

Biol Chem. 2012 Sep;393(9):889-98. doi: 10.1515/hsz-2012-0178. Review.

PMID:
22944689
11.

Evidence for allosteric linkage between exosites 1 and 2 of thrombin.

Fredenburgh JC, Stafford AR, Weitz JI.

J Biol Chem. 1997 Oct 10;272(41):25493-9.

12.

Congenital prothrombin deficiency: an update.

Lancellotti S, Basso M, De Cristofaro R.

Semin Thromb Hemost. 2013 Sep;39(6):596-606. doi: 10.1055/s-0033-1348948. Epub 2013 Jul 12. Review.

PMID:
23852823
13.

NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation.

Lechtenberg BC, Johnson DJ, Freund SM, Huntington JA.

Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14087-92. doi: 10.1073/pnas.1005255107. Epub 2010 Jul 21.

14.

Characterization of bothrojaracin interaction with human prothrombin.

Monteiro RQ, Bock PE, Bianconi ML, Zingali RB.

Protein Sci. 2001 Sep;10(9):1897-904.

15.

Amide H/2H exchange reveals a mechanism of thrombin activation.

Koeppe JR, Komives EA.

Biochemistry. 2006 Jun 27;45(25):7724-32.

16.

Thermodynamic compensation upon binding to exosite 1 and the active site of thrombin.

Treuheit NA, Beach MA, Komives EA.

Biochemistry. 2011 May 31;50(21):4590-6. doi: 10.1021/bi2004069. Epub 2011 May 6.

17.

Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation.

Friedrich R, Panizzi P, Fuentes-Prior P, Richter K, Verhamme I, Anderson PJ, Kawabata S, Huber R, Bode W, Bock PE.

Nature. 2003 Oct 2;425(6957):535-9.

PMID:
14523451
18.
19.

Long range communication between exosites 1 and 2 modulates thrombin function.

Petrera NS, Stafford AR, Leslie BA, Kretz CA, Fredenburgh JC, Weitz JI.

J Biol Chem. 2009 Sep 18;284(38):25620-9. doi: 10.1074/jbc.M109.000042. Epub 2009 Jul 9. Erratum in: J Biol Chem. 2015 Feb 20;290(8):4814.

20.

Identification of protease exosite-interacting peptides that enhance substrate cleavage kinetics.

Jabaiah AM, Getz JA, Witkowski WA, Hardy JA, Daugherty PS.

Biol Chem. 2012 Sep;393(9):933-41. doi: 10.1515/hsz-2012-0162.

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