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Items: 1 to 20 of 119

1.

Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes.

Nelson O, Supnet C, Liu H, Bezprozvanny I.

J Alzheimers Dis. 2010;21(3):781-93. doi: 10.3233/JAD-2010-100159.

2.

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.

Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I.

J Clin Invest. 2007 May;117(5):1230-9. Epub 2007 Apr 12.

3.

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.

Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I.

Cell. 2006 Sep 8;126(5):981-93.

4.

Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.

Supnet C, Bezprozvanny I.

Sci China Life Sci. 2011 Aug;54(8):744-51. doi: 10.1007/s11427-011-4201-y. Epub 2011 Jul 24. Review.

PMID:
21786197
5.

Presenilins and calcium signaling-systems biology to the rescue.

Bezprozvanny I.

Sci Signal. 2013 Jul 9;6(283):pe24. doi: 10.1126/scisignal.2004296. Review.

6.

Role of presenilins in neuronal calcium homeostasis.

Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I.

J Neurosci. 2010 Jun 23;30(25):8566-80. doi: 10.1523/JNEUROSCI.1554-10.2010.

7.

Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations.

Das HK, Tchedre K, Mueller B.

J Neurochem. 2012 Aug;122(3):487-500. doi: 10.1111/j.1471-4159.2012.07794.x. Epub 2012 Jun 22.

8.

Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.

Supnet C, Bezprozvanny I.

Cell Calcium. 2011 Sep;50(3):303-9. doi: 10.1016/j.ceca.2011.05.013. Epub 2011 Jun 12. Review.

9.

Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.

Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.

Cell Calcium. 2006 Jun;39(6):539-50. Epub 2006 Apr 18.

PMID:
16620965
10.

Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.

Shilling D, Mak DO, Kang DE, Foskett JK.

J Biol Chem. 2012 Mar 30;287(14):10933-44. doi: 10.1074/jbc.M111.300491. Epub 2012 Feb 6.

11.

Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.

Honarnejad K, Jung CK, Lammich S, Arzberger T, Kretzschmar H, Herms J.

J Cell Mol Med. 2013 Feb;17(2):293-302. doi: 10.1111/jcmm.12008. Epub 2013 Feb 5.

12.

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.

Cacquevel M, Aeschbach L, Houacine J, Fraering PC.

PLoS One. 2012;7(4):e35133. doi: 10.1371/journal.pone.0035133. Epub 2012 Apr 18.

13.

Attenuated presenilin-1 endoproteolysis enhances store-operated calcium currents in neuronal cells.

Ryazantseva M, Skobeleva K, Glushankova L, Kaznacheyeva E.

J Neurochem. 2016 Mar;136(5):1085-95. doi: 10.1111/jnc.13495. Epub 2016 Jan 11.

14.

Presenilin transgenic mice as models of Alzheimer's disease.

Elder GA, Gama Sosa MA, De Gasperi R, Dickstein DL, Hof PR.

Brain Struct Funct. 2010 Mar;214(2-3):127-43. doi: 10.1007/s00429-009-0227-3. Epub 2009 Nov 18. Review.

15.

G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.

Chen WT, Hsieh YF, Huang YJ, Lin CC, Lin YT, Liu YC, Lien CC, Cheng IH.

Mol Neurobiol. 2015 Dec;52(3):1835-1849. doi: 10.1007/s12035-014-8969-1. Epub 2014 Nov 15.

PMID:
25394380
16.

Physiological functions of presenilins; beyond γ-secretase.

Stiller I, Lizák B, Bánhegyi G.

Curr Pharm Biotechnol. 2014;15(11):1019-25. Review.

PMID:
25420727
17.

Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis.

Sepulveda-Falla D, Barrera-Ocampo A, Hagel C, Korwitz A, Vinueza-Veloz MF, Zhou K, Schonewille M, Zhou H, Velazquez-Perez L, Rodriguez-Labrada R, Villegas A, Ferrer I, Lopera F, Langer T, De Zeeuw CI, Glatzel M.

J Clin Invest. 2014 Apr;124(4):1552-67. doi: 10.1172/JCI66407. Epub 2014 Feb 24.

18.

Presenilins: how much more than γ-secretase?!

Coen K, Annaert W.

Biochem Soc Trans. 2010 Dec;38(6):1474-8. doi: 10.1042/BST0381474.

PMID:
21118110
19.

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.

Biochemistry. 1998 Nov 24;37(47):16465-71.

PMID:
9843412
20.

Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.

PMID:
10653281

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