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Nrf2 and PPAR{gamma}: PPARtnering against oxidant-induced lung injury.

Reddy RC, Standiford TJ.

Am J Respir Crit Care Med. 2010 Jul 15;182(2):134-5. doi: 10.1164/rccm.201004-0457ED. No abstract available.


Nrf2-regulated PPAR{gamma} expression is critical to protection against acute lung injury in mice.

Cho HY, Gladwell W, Wang X, Chorley B, Bell D, Reddy SP, Kleeberger SR.

Am J Respir Crit Care Med. 2010 Jul 15;182(2):170-82. doi: 10.1164/rccm.200907-1047OC.


Endogenous prostaglandin D2 and its metabolites protect the heart against ischemia-reperfusion injury by activating Nrf2.

Katsumata Y, Shinmura K, Sugiura Y, Tohyama S, Matsuhashi T, Ito H, Yan X, Ito K, Yuasa S, Ieda M, Urade Y, Suematsu M, Fukuda K, Sano M.

Hypertension. 2014 Jan;63(1):80-7. doi: 10.1161/HYPERTENSIONAHA.113.01639.


Nrf2 is essential for the expression of lipocalin-prostaglandin D synthase induced by prostaglandin D2.

Kim KH, Sadikot RT, Xiao L, Christman JW, Freeman ML, Chan JY, Oh YK, Blackwell TS, Joo M.

Free Radic Biol Med. 2013 Dec;65:1134-42. doi: 10.1016/j.freeradbiomed.2013.08.192.


N-acetylcysteine attenuates phosgene-induced acute lung injury via up-regulation of Nrf2 expression.

Ji L, Liu R, Zhang XD, Chen HL, Bai H, Wang X, Zhao HL, Liang X, Hai CX.

Inhal Toxicol. 2010 Jun;22(7):535-42. doi: 10.3109/08958370903525183.


Protection of RPE cells from oxidative injury by 15-deoxy-delta12,14-prostaglandin J2 by augmenting GSH and activating MAPK.

Qin S, McLaughlin AP, De Vries GW.

Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5098-105.


NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury.

Davidson BA, Vethanayagam RR, Grimm MJ, Mullan BA, Raghavendran K, Blackwell TS, Freeman ML, Ayyasamy V, Singh KK, Sporn MB, Itagaki K, Hauser CJ, Knight PR, Segal BH.

J Immunol. 2013 Feb 15;190(4):1714-24. doi: 10.4049/jimmunol.1202410.


Inhibitory effects of rosiglitazone on paraquat-induced acute lung injury in rats.

Liu ZN, Zhao M, Zheng Q, Zhao HY, Hou WJ, Bai SL.

Acta Pharmacol Sin. 2013 Oct;34(10):1317-24. doi: 10.1038/aps.2013.65.


[The roles of PPAR-gamma/PGC-1alpha to Nrf2/gamma-GCS-h in lung of guinea pigs with bronchial asthma].

Chen J, Dai AG, Fu MJ, Long ZG, Zhu LM.

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2011 May;27(2):225-9. Chinese.


15-Deoxy-Δ(12,14)-prostaglandin J2 prevents oxidative injury by upregulating the expression of aldose reductase in vascular smooth muscle cells.

Kang ES, Hwang JS, Ham SA, Park MH, Kim GH, Paek KS, Yoo T, Lee WJ, Kang KR, Lee JH, Choi YJ, Seo HG.

Free Radic Res. 2014 Feb;48(2):218-29. doi: 10.3109/10715762.2013.860224.


15-Deoxy-12,14-prostaglandin J2 inhibits interferon gamma induced MHC class II but not class I expression on ARPE cells through a PPAR gamma independent mechanism.

Willermain F, Dulku S, Gonzalez NS, Blero D, Driessens G, De Graef C, Caspers L, Bruyns C.

Prostaglandins Other Lipid Mediat. 2006 Sep;80(3-4):136-43.


Role of NF-kappaB and PPAR-gamma in lung inflammation induced by monocyte-derived microparticles.

Neri T, Armani C, Pegoli A, Cordazzo C, Carmazzi Y, Brunelleschi S, Bardelli C, Breschi MC, Paggiaro P, Celi A.

Eur Respir J. 2011 Jun;37(6):1494-502. doi: 10.1183/09031936.00023310.


15-Deoxy-prostaglandin J2 anti-inflammation in a rat model of chronic obstructive pulmonary disease and human bronchial epithelial cells via Nrf2 activation.

Li XY, Luo BL, Wang LJ, Zhang WD, Liu ZG.

Genet Mol Res. 2015 Oct 30;14(4):14037-42. doi: 10.4238/2015.October.29.22.


[The protective effects and mechanisms of peroxisome proliferator-activated receptor-gamma agonist in rats with acute lung injury].

Wang JC, Jiang P, Huang J, Qian GS.

Zhonghua Jie He He Hu Xi Za Zhi. 2008 Jun;31(6):425-30. Chinese.


Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation.

Reddy NM, Potteti HR, Mariani TJ, Biswal S, Reddy SP.

Am J Respir Cell Mol Biol. 2011 Dec;45(6):1161-8. doi: 10.1165/rcmb.2011-0144OC.


Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, ligands of the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), reduce ischaemia/reperfusion injury of the gut.

Cuzzocrea S, Pisano B, Dugo L, Ianaro A, Patel NS, Di Paola R, Genovese T, Chatterjee PK, Di Rosa M, Caputi AP, Thiemermann C.

Br J Pharmacol. 2003 Sep;140(2):366-76.

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