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Items: 1 to 20 of 82

1.

Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway.

Hui W, Litherland GJ, Jefferson M, Barter MJ, Elias MS, Cawston TE, Rowan AD, Young DA.

Rheumatology (Oxford). 2010 Nov;49(11):2043-53. doi: 10.1093/rheumatology/keq217. Epub 2010 Jul 15.

PMID:
20634235
2.

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases.

Hui W, Litherland GJ, Elias MS, Kitson GI, Cawston TE, Rowan AD, Young DA.

Ann Rheum Dis. 2012 Mar;71(3):455-62. doi: 10.1136/annrheumdis-2011-200372. Epub 2011 Nov 9.

PMID:
22072016
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Lithium protects against cartilage degradation in osteoarthritis.

Minashima T, Zhang Y, Lee Y, Kirsch T.

Arthritis Rheumatol. 2014 May;66(5):1228-36. doi: 10.1002/art.38373.

8.

Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production by down-regulating JNK-AP-1 signaling in human chondrocytes.

Ho LJ, Lin LC, Hung LF, Wang SJ, Lee CH, Chang DM, Lai JH, Tai TY.

Biochem Pharmacol. 2005 Jul 15;70(2):200-8.

PMID:
15946654
10.

IL-1- and TNF-induced bone resorption is mediated by p38 mitogen activated protein kinase.

Kumar S, Votta BJ, Rieman DJ, Badger AM, Gowen M, Lee JC.

J Cell Physiol. 2001 Jun;187(3):294-303.

PMID:
11319753
11.

Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation.

Karsdal MA, Sumer EU, Wulf H, Madsen SH, Christiansen C, Fosang AJ, Sondergaard BC.

Arthritis Rheum. 2007 May;56(5):1549-58.

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Esculetin inhibits cartilage resorption induced by interleukin 1alpha in combination with oncostatin M.

Elliott S, Rowan AD, Carrère S, Koshy P, Catterall JB, Cawston TE.

Ann Rheum Dis. 2001 Feb;60(2):158-65.

18.

The antioxidant resveratrol protects against chondrocyte apoptosis via effects on mitochondrial polarization and ATP production.

Dave M, Attur M, Palmer G, Al-Mussawir HE, Kennish L, Patel J, Abramson SB.

Arthritis Rheum. 2008 Sep;58(9):2786-97. doi: 10.1002/art.23799.

19.

Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases.

Lakey RL, Cawston TE.

Rheumatology (Oxford). 2009 Oct;48(10):1208-12. doi: 10.1093/rheumatology/kep236. Epub 2009 Aug 18.

PMID:
19690126
20.

The chondroprotective agent ITZ-1 inhibits interleukin-1beta-induced matrix metalloproteinase-13 production and suppresses nitric oxide-induced chondrocyte death.

Kimura H, Yukitake H, Suzuki H, Tajima Y, Gomaibashi K, Morimoto S, Funabashi Y, Yamada K, Takizawa M.

J Pharmacol Sci. 2009 Jun;110(2):201-11.

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