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Items: 1 to 20 of 192

1.

Atorvastatin attenuates hepatic fibrosis in rats after bile duct ligation via decreased turnover of hepatic stellate cells.

Trebicka J, Hennenberg M, Odenthal M, Shir K, Klein S, Granzow M, Vogt A, Dienes HP, Lammert F, Reichen J, Heller J, Sauerbruch T.

J Hepatol. 2010 Oct;53(4):702-12. doi: 10.1016/j.jhep.2010.04.025. Epub 2010 Jun 18.

PMID:
20633948
2.

Atorvastatin inhibits proliferation and apoptosis, but induces senescence in hepatic myofibroblasts and thereby attenuates hepatic fibrosis in rats.

Klein S, Klösel J, Schierwagen R, Körner C, Granzow M, Huss S, Mazar IG, Weber S, van den Ven PF, Pieper-Fürst U, Fürst DO, Nattermann J, Lammert F, Sauerbruch T, Trebicka J.

Lab Invest. 2012 Oct;92(10):1440-50. doi: 10.1038/labinvest.2012.106. Epub 2012 Aug 13.

3.

Hepatic and HSC-specific sorafenib effects in rats with established secondary biliary cirrhosis.

Hennenberg M, Trebicka J, Kohistani Z, Stark C, Nischalke HD, Krämer B, Körner C, Klein S, Granzow M, Fischer HP, Heller J, Sauerbruch T.

Lab Invest. 2011 Feb;91(2):241-51. doi: 10.1038/labinvest.2010.148. Epub 2010 Oct 4.

4.

The Salvia miltiorrhiza monomer IH764-3 induces apoptosis of hepatic stellate cells in vivo in a bile duct ligation-induced model of liver fibrosis.

Liu L, Wei J, Huo X, Fang S, Yao D, Gao J, Jiang H, Zhang X.

Mol Med Rep. 2012 Dec;6(6):1231-8. doi: 10.3892/mmr.2012.1076. Epub 2012 Sep 11.

PMID:
22971838
5.

The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse.

Canbay A, Feldstein A, Baskin-Bey E, Bronk SF, Gores GJ.

J Pharmacol Exp Ther. 2004 Mar;308(3):1191-6. Epub 2003 Nov 14.

6.

Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats.

Abramovitch S, Dahan-Bachar L, Sharvit E, Weisman Y, Ben Tov A, Brazowski E, Reif S.

Gut. 2011 Dec;60(12):1728-37. doi: 10.1136/gut.2010.234666. Epub 2011 Aug 4.

PMID:
21816960
7.

Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase.

Trebicka J, Hennenberg M, Laleman W, Shelest N, Biecker E, Schepke M, Nevens F, Sauerbruch T, Heller J.

Hepatology. 2007 Jul;46(1):242-53.

PMID:
17596891
8.

Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats.

Paik YH, Kim JK, Lee JI, Kang SH, Kim DY, An SH, Lee SJ, Lee DK, Han KH, Chon CY, Lee SI, Lee KS, Brenner DA.

Gut. 2009 Nov;58(11):1517-27. doi: 10.1136/gut.2008.157420. Epub 2009 Feb 6.

PMID:
19201774
9.

Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat.

Tuchweber B, Desmoulière A, Bochaton-Piallat ML, Rubbia-Brandt L, Gabbiani G.

Lab Invest. 1996 Jan;74(1):265-78.

PMID:
8569191
10.

Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.

Galli A, Crabb DW, Ceni E, Salzano R, Mello T, Svegliati-Baroni G, Ridolfi F, Trozzi L, Surrenti C, Casini A.

Gastroenterology. 2002 Jun;122(7):1924-40.

PMID:
12055599
11.

Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib.

Liu Y, Wang Z, Kwong SQ, Lui EL, Friedman SL, Li FR, Lam RW, Zhang GC, Zhang H, Ye T.

J Hepatol. 2011 Sep;55(3):612-25. doi: 10.1016/j.jhep.2010.11.035. Epub 2011 Jan 18.

PMID:
21251937
12.

Atorvastatin attenuates angiotensin II-induced inflammatory actions in the liver.

Moreno M, Ramalho LN, Sancho-Bru P, Ruiz-Ortega M, Ramalho F, Abraldes JG, Colmenero J, Dominguez M, Egido J, Arroyo V, Ginès P, Bataller R.

Am J Physiol Gastrointest Liver Physiol. 2009 Feb;296(2):G147-56. doi: 10.1152/ajpgi.00462.2007. Epub 2008 Dec 4.

13.

Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells.

Wang X, Ikejima K, Kon K, Arai K, Aoyama T, Okumura K, Abe W, Sato N, Watanabe S.

J Hepatol. 2011 Aug;55(2):379-87. doi: 10.1016/j.jhep.2010.10.040. Epub 2010 Dec 17.

PMID:
21168456
14.

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis.

Wang Y, Gao J, Zhang D, Zhang J, Ma J, Jiang H.

J Hepatol. 2010 Jul;53(1):132-44. doi: 10.1016/j.jhep.2010.02.027. Epub 2010 Apr 13.

PMID:
20447716
15.

Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats.

Li J, Liu P, Zhang R, Cao L, Qian H, Liao J, Xu W, Wu M, Yin Z.

J Ethnopharmacol. 2011 Sep 1;137(1):714-23. doi: 10.1016/j.jep.2011.06.030. Epub 2011 Jun 24.

PMID:
21726622
16.
17.

Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats.

Dooley S, Hamzavi J, Breitkopf K, Wiercinska E, Said HM, Lorenzen J, Ten Dijke P, Gressner AM.

Gastroenterology. 2003 Jul;125(1):178-91.

PMID:
12851882
18.

The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis.

Kinnman N, Francoz C, Barbu V, Wendum D, Rey C, Hultcrantz R, Poupon R, Housset C.

Lab Invest. 2003 Feb;83(2):163-73.

PMID:
12594232
19.

Atorvastatin action involves diminished recovery of hepatic HMG-CoA reductase activity.

Ness GC, Chambers CM, Lopez D.

J Lipid Res. 1998 Jan;39(1):75-84.

20.

A new histone deacetylase inhibitor improves liver fibrosis in BDL rats through suppression of hepatic stellate cells.

Park KC, Park JH, Jeon JY, Kim SY, Kim JM, Lim CY, Lee TH, Kim HK, Lee HG, Kim SM, Kwon HJ, Suh JS, Kim SW, Choi SH.

Br J Pharmacol. 2014 Nov;171(21):4820-30. doi: 10.1111/bph.12590. Epub 2014 Sep 5.

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