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Items: 1 to 20 of 150

1.

Successful amelioration of mitochondrial optic neuropathy using the yeast NDI1 gene in a rat animal model.

Marella M, Seo BB, Thomas BB, Matsuno-Yagi A, Yagi T.

PLoS One. 2010 Jul 8;5(7):e11472. doi: 10.1371/journal.pone.0011472.

2.

Intravitreal delivery of AAV-NDI1 provides functional benefit in a murine model of Leber hereditary optic neuropathy.

Chadderton N, Palfi A, Millington-Ward S, Gobbo O, Overlack N, Carrigan M, O'Reilly M, Campbell M, Ehrhardt C, Wolfrum U, Humphries P, Kenna PF, Farrar GJ.

Eur J Hum Genet. 2013 Jan;21(1):62-8. doi: 10.1038/ejhg.2012.112. Epub 2012 Jun 6.

3.

Cell therapy using retinal progenitor cells shows therapeutic effect in a chemically-induced rotenone mouse model of Leber hereditary optic neuropathy.

Mansergh FC, Chadderton N, Kenna PF, Gobbo OL, Farrar GJ.

Eur J Hum Genet. 2014 Nov;22(11):1314-20. doi: 10.1038/ejhg.2014.26. Epub 2014 Feb 26.

4.

LHON gene therapy vector prevents visual loss and optic neuropathy induced by G11778A mutant mitochondrial DNA: biodistribution and toxicology profile.

Koilkonda R, Yu H, Talla V, Porciatti V, Feuer WJ, Hauswirth WW, Chiodo V, Erger KE, Boye SL, Lewin AS, Conlon TJ, Renner L, Neuringer M, Detrisac C, Guy J.

Invest Ophthalmol Vis Sci. 2014 Oct 23;55(12):7739-53. doi: 10.1167/iovs.14-15388.

5.

Safety and effects of the vector for the Leber hereditary optic neuropathy gene therapy clinical trial.

Koilkonda RD, Yu H, Chou TH, Feuer WJ, Ruggeri M, Porciatti V, Tse D, Hauswirth WW, Chiodo V, Boye SL, Lewin AS, Neuringer M, Renner L, Guy J.

JAMA Ophthalmol. 2014 Apr 1;132(4):409-20. doi: 10.1001/jamaophthalmol.2013.7630.

6.

Mutant NADH dehydrogenase subunit 4 gene delivery to mitochondria by targeting sequence-modified adeno-associated virus induces visual loss and optic atrophy in mice.

Yu H, Ozdemir SS, Koilkonda RD, Chou TH, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Lewin AS, Guy J.

Mol Vis. 2012;18:1668-83. Epub 2012 Jun 20.

7.

Idebenone protects against retinal damage and loss of vision in a mouse model of Leber's hereditary optic neuropathy.

Heitz FD, Erb M, Anklin C, Robay D, Pernet V, Gueven N.

PLoS One. 2012;7(9):e45182. doi: 10.1371/journal.pone.0045182. Epub 2012 Sep 18.

8.

Long-term evaluation of Leber's hereditary optic neuropathy-like symptoms in rotenone administered rats.

Zhang L, Liu L, Philip AL, Martinez JC, Guttierez JC, Marella M, Patki G, Matsuno-Yagi A, Yagi T, Thomas BB.

Neurosci Lett. 2015 Jan 12;585:171-6. doi: 10.1016/j.neulet.2014.12.004. Epub 2014 Dec 3.

9.

Leber hereditary optic neuropathy gene therapy clinical trial recruitment: year 1.

Lam BL, Feuer WJ, Abukhalil F, Porciatti V, Hauswirth WW, Guy J.

Arch Ophthalmol. 2010 Sep;128(9):1129-35. doi: 10.1001/archophthalmol.2010.201.

11.

Trial end points and natural history in patients with G11778A Leber hereditary optic neuropathy : preparation for gene therapy clinical trial.

Lam BL, Feuer WJ, Schiffman JC, Porciatti V, Vandenbroucke R, Rosa PR, Gregori G, Guy J.

JAMA Ophthalmol. 2014 Apr 1;132(4):428-36. doi: 10.1001/jamaophthalmol.2013.7971.

12.

Long-term outcomes of gene therapy for the treatment of Leber's hereditary optic neuropathy.

Yang S, Ma SQ, Wan X, He H, Pei H, Zhao MJ, Chen C, Wang DW, Dong XY, Yuan JJ, Li B.

EBioMedicine. 2016 Aug;10:258-68. doi: 10.1016/j.ebiom.2016.07.002. Epub 2016 Jul 6.

13.

Complex I inhibition in the visual pathway induces disorganization of the node of Ranvier.

Marella M, Patki G, Matsuno-Yagi A, Yagi T.

Neurobiol Dis. 2013 Oct;58:281-8. doi: 10.1016/j.nbd.2013.06.010. Epub 2013 Jun 29.

14.

Partial mitochondrial complex I inhibition induces oxidative damage and perturbs glutamate transport in primary retinal cultures. Relevance to Leber Hereditary Optic Neuropathy (LHON).

Beretta S, Wood JP, Derham B, Sala G, Tremolizzo L, Ferrarese C, Osborne NN.

Neurobiol Dis. 2006 Nov;24(2):308-17. Epub 2006 Sep 7.

PMID:
16959493
15.

Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.

Yu-Wai-Man P, Griffiths PG, Chinnery PF.

Prog Retin Eye Res. 2011 Mar;30(2):81-114. doi: 10.1016/j.preteyeres.2010.11.002. Epub 2010 Nov 26. Review.

16.

Mitochondrial dysfunction as a cause of optic neuropathies.

Carelli V, Ross-Cisneros FN, Sadun AA.

Prog Retin Eye Res. 2004 Jan;23(1):53-89. Review.

PMID:
14766317
17.

Oestrogens ameliorate mitochondrial dysfunction in Leber's hereditary optic neuropathy.

Giordano C, Montopoli M, Perli E, Orlandi M, Fantin M, Ross-Cisneros FN, Caparrotta L, Martinuzzi A, Ragazzi E, Ghelli A, Sadun AA, d'Amati G, Carelli V.

Brain. 2011 Jan;134(Pt 1):220-34. doi: 10.1093/brain/awq276. Epub 2010 Oct 13.

18.

NADH-dehydrogenase type-2 suppresses irreversible visual loss and neurodegeneration in the EAE animal model of MS.

Talla V, Yu H, Chou TH, Porciatti V, Chiodo V, Boye SL, Hauswirth WW, Lewin AS, Guy J.

Mol Ther. 2013 Oct;21(10):1876-88. doi: 10.1038/mt.2013.104. Epub 2013 Jun 11.

19.

Mathematically modeling the involvement of axons in Leber's hereditary optic neuropathy.

Pan BX, Ross-Cisneros FN, Carelli V, Rue KS, Salomao SR, Moraes-Filho MN, Moraes MN, Berezovsky A, Belfort R Jr, Sadun AA.

Invest Ophthalmol Vis Sci. 2012 Nov 9;53(12):7608-17. doi: 10.1167/iovs.12-10452.

20.

Gene delivery to mitochondria by targeting modified adenoassociated virus suppresses Leber's hereditary optic neuropathy in a mouse model.

Yu H, Koilkonda RD, Chou TH, Porciatti V, Ozdemir SS, Chiodo V, Boye SL, Boye SE, Hauswirth WW, Lewin AS, Guy J.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):E1238-47. doi: 10.1073/pnas.1119577109. Epub 2012 Apr 20.

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