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Items: 1 to 20 of 210

1.

TGFBR2 mutations alter smooth muscle cell phenotype and predispose to thoracic aortic aneurysms and dissections.

Inamoto S, Kwartler CS, Lafont AL, Liang YY, Fadulu VT, Duraisamy S, Willing M, Estrera A, Safi H, Hannibal MC, Carey J, Wiktorowicz J, Tan FK, Feng XH, Pannu H, Milewicz DM.

Cardiovasc Res. 2010 Dec 1;88(3):520-9. doi: 10.1093/cvr/cvq230. Epub 2010 Jul 13.

2.

Altered Smooth Muscle Cell Force Generation as a Driver of Thoracic Aortic Aneurysms and Dissections.

Milewicz DM, Trybus KM, Guo DC, Sweeney HL, Regalado E, Kamm K, Stull JT.

Arterioscler Thromb Vasc Biol. 2017 Jan;37(1):26-34. doi: 10.1161/ATVBAHA.116.303229. Epub 2016 Nov 22. Review. Erratum in: Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):e12.

3.

Analysis of multigenerational families with thoracic aortic aneurysms and dissections due to TGFBR1 or TGFBR2 mutations.

Tran-Fadulu V, Pannu H, Kim DH, Vick GW 3rd, Lonsford CM, Lafont AL, Boccalandro C, Smart S, Peterson KL, Hain JZ, Willing MC, Coselli JS, LeMaire SA, Ahn C, Byers PH, Milewicz DM.

J Med Genet. 2009 Sep;46(9):607-13. doi: 10.1136/jmg.2008.062844. Epub 2009 Jun 18.

PMID:
19542084
4.

Postnatal Deletion of the Type II Transforming Growth Factor-β Receptor in Smooth Muscle Cells Causes Severe Aortopathy in Mice.

Hu JH, Wei H, Jaffe M, Airhart N, Du L, Angelov SN, Yan J, Allen JK, Kang I, Wight TN, Fox K, Smith A, Enstrom R, Dichek DA.

Arterioscler Thromb Vasc Biol. 2015 Dec;35(12):2647-56. doi: 10.1161/ATVBAHA.115.306573. Epub 2015 Oct 22.

5.

Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections.

Pannu H, Fadulu VT, Chang J, Lafont A, Hasham SN, Sparks E, Giampietro PF, Zaleski C, Estrera AL, Safi HJ, Shete S, Willing MC, Raman CS, Milewicz DM.

Circulation. 2005 Jul 26;112(4):513-20. Epub 2005 Jul 18.

PMID:
16027248
6.

Pharmacologically Improved Contractility Protects Against Aortic Dissection in Mice With Disrupted Transforming Growth Factor-β Signaling Despite Compromised Extracellular Matrix Properties.

Ferruzzi J, Murtada SI, Li G, Jiao Y, Uman S, Ting MY, Tellides G, Humphrey JD.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):919-27. doi: 10.1161/ATVBAHA.116.307436. Epub 2016 Mar 17.

7.

Structure of the Elastin-Contractile Units in the Thoracic Aorta and How Genes That Cause Thoracic Aortic Aneurysms and Dissections Disrupt This Structure.

Karimi A, Milewicz DM.

Can J Cardiol. 2016 Jan;32(1):26-34. doi: 10.1016/j.cjca.2015.11.004. Epub 2015 Nov 10. Review.

8.

TGF-β (Transforming Growth Factor-β) Signaling Protects the Thoracic and Abdominal Aorta From Angiotensin II-Induced Pathology by Distinct Mechanisms.

Angelov SN, Hu JH, Wei H, Airhart N, Shi M, Dichek DA.

Arterioscler Thromb Vasc Biol. 2017 Nov;37(11):2102-2113. doi: 10.1161/ATVBAHA.117.309401. Epub 2017 Jul 20.

9.

BRG1 overexpression in smooth muscle cells promotes the development of thoracic aortic dissection.

Yuan Y, Wang C, Xu J, Tao J, Xu Z, Huang S.

BMC Cardiovasc Disord. 2014 Oct 11;14:144. doi: 10.1186/1471-2261-14-144.

10.

Smooth muscle cell phenotypic diversity between dissected and unaffected thoracic aortic media.

Zhang J, Wang L, Fu W, Wang C, Guo D, Jiang J, Wang Y.

J Cardiovasc Surg (Torino). 2013 Aug;54(4):511-21. Epub 2013 Apr 18.

PMID:
23594508
11.

FOXE3 mutations predispose to thoracic aortic aneurysms and dissections.

Kuang SQ, Medina-Martinez O, Guo DC, Gong L, Regalado ES, Reynolds CL, Boileau C, Jondeau G, Prakash SK, Kwartler CS, Zhu LY, Peters AM, Duan XY, Bamshad MJ, Shendure J, Nickerson DA, Santos-Cortez RL, Dong X, Leal SM, Majesky MW, Swindell EC, Jamrich M, Milewicz DM.

J Clin Invest. 2016 Mar 1;126(3):948-61. doi: 10.1172/JCI83778. Epub 2016 Feb 8.

12.

Transforming growth factor-beta1-induced expression of smooth muscle marker genes involves activation of PKN and p38 MAPK.

Deaton RA, Su C, Valencia TG, Grant SR.

J Biol Chem. 2005 Sep 2;280(35):31172-81. Epub 2005 Jun 26.

13.

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis.

Li W, Li Q, Jiao Y, Qin L, Ali R, Zhou J, Ferruzzi J, Kim RW, Geirsson A, Dietz HC, Offermanns S, Humphrey JD, Tellides G.

J Clin Invest. 2014 Feb;124(2):755-67. doi: 10.1172/JCI69942. Epub 2014 Jan 9.

14.

Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.

Guo DC, Papke CL, Tran-Fadulu V, Regalado ES, Avidan N, Johnson RJ, Kim DH, Pannu H, Willing MC, Sparks E, Pyeritz RE, Singh MN, Dalman RL, Grotta JC, Marian AJ, Boerwinkle EA, Frazier LQ, LeMaire SA, Coselli JS, Estrera AL, Safi HJ, Veeraraghavan S, Muzny DM, Wheeler DA, Willerson JT, Yu RK, Shete SS, Scherer SE, Raman CS, Buja LM, Milewicz DM.

Am J Hum Genet. 2009 May;84(5):617-27. doi: 10.1016/j.ajhg.2009.04.007. Epub 2009 Apr 30.

15.

Transforming growth factor-beta1 signaling contributes to development of smooth muscle cells from embryonic stem cells.

Sinha S, Hoofnagle MH, Kingston PA, McCanna ME, Owens GK.

Am J Physiol Cell Physiol. 2004 Dec;287(6):C1560-8. Epub 2004 Aug 11.

16.

Exon 47 skipping of fibrillin-1 leads preferentially to cardiovascular defects in patients with thoracic aortic aneurysms and dissections.

Wang WJ, Han P, Zheng J, Hu FY, Zhu Y, Xie JS, Guo J, Zhang Z, Dong J, Zheng GY, Cao H, Liu TS, Fu Q, Sun L, Yang BB, Tian XL.

J Mol Med (Berl). 2013 Jan;91(1):37-47. doi: 10.1007/s00109-012-0931-y. Epub 2012 Jul 8.

PMID:
22772377
17.

Disruption of TGF-β signaling in smooth muscle cell prevents elastase-induced abdominal aortic aneurysm.

Gao F, Chambon P, Offermanns S, Tellides G, Kong W, Zhang X, Li W.

Biochem Biophys Res Commun. 2014 Nov 7;454(1):137-43. doi: 10.1016/j.bbrc.2014.10.053. Epub 2014 Oct 18. Erratum in: Biochem Biophys Res Commun. 2015 May 8;460(3):887.

PMID:
25450370
18.

Smad2-dependent protease nexin-1 overexpression differentiates chronic aneurysms from acute dissections of human ascending aorta.

Gomez D, Kessler K, Borges LF, Richard B, Touat Z, Ollivier V, Mansilla S, Bouton MC, Alkoder S, Nataf P, Jandrot-Perrus M, Jondeau G, Vranckx R, Michel JB.

Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2222-32. doi: 10.1161/ATVBAHA.113.301327. Epub 2013 Jun 27.

PMID:
23814118
19.

Genetic basis of thoracic aortic aneurysms and dissections: focus on smooth muscle cell contractile dysfunction.

Milewicz DM, Guo DC, Tran-Fadulu V, Lafont AL, Papke CL, Inamoto S, Kwartler CS, Pannu H.

Annu Rev Genomics Hum Genet. 2008;9:283-302. doi: 10.1146/annurev.genom.8.080706.092303. Review.

PMID:
18544034
20.

Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling.

Wei H, Hu JH, Angelov SN, Fox K, Yan J, Enstrom R, Smith A, Dichek DA.

J Am Heart Assoc. 2017 Jan 24;6(1). pii: e004968. doi: 10.1161/JAHA.116.004968.

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