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Items: 1 to 20 of 120

1.

Identification of a sulfonamide series of CCR2 antagonists.

Peace S, Philp J, Brooks C, Piercy V, Moores K, Smethurst C, Watson S, Gaines S, Zippoli M, Mookherjee C, Ife R.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3961-4. doi: 10.1016/j.bmcl.2010.04.142. Epub 2010 May 7.

PMID:
20627722
2.

Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists.

Zhang X, Hufnagel H, Markotan T, Lanter J, Cai C, Hou C, Singer M, Opas E, McKenney S, Crysler C, Johnson D, Sui Z.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5577-82. doi: 10.1016/j.bmcl.2011.06.080. Epub 2011 Jun 29.

PMID:
21783361
3.

CCR2 receptor antagonists: optimization of biaryl sulfonamides to increase activity in whole blood.

Wang GZ, Haile PA, Daniel T, Belot B, Viet AQ, Goodman KB, Sha D, Dowdell SE, Varga N, Hong X, Chakravorty S, Webb C, Cornejo C, Olzinski A, Bernard R, Evans C, Emmons A, Briand J, Chung CW, Quek R, Lee D, Gough PJ, Sehon CA.

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7291-4. doi: 10.1016/j.bmcl.2011.10.038. Epub 2011 Oct 19.

PMID:
22047688
4.

Synthesis, structure-activity relationship and in vivo antiinflammatory efficacy of substituted dipiperidines as CCR2 antagonists.

Xia M, Hou C, DeMong DE, Pollack SR, Pan M, Brackley JA, Jain N, Gerchak C, Singer M, Malaviya R, Matheis M, Olini G, Cavender D, Wachter M.

J Med Chem. 2007 Nov 15;50(23):5561-3. Epub 2007 Oct 11.

PMID:
17929797
5.

Substituted dipiperidine alcohols as potent CCR2 antagonists.

Xia M, Hou C, Demong D, Pollack S, Pan M, Brackley J, Singer M, Matheis M, Cavender D, Wachter M.

Bioorg Med Chem Lett. 2008 Jun 15;18(12):3562-4. doi: 10.1016/j.bmcl.2008.05.010. Epub 2008 May 4.

PMID:
18487045
6.

Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptor antagonists.

Hategan G, Polozov AM, Zeller W, Cao H, Mishra RK, Kiselyov AS, Ramirez J, Halldorsdottir G, Andrésson T, Gurney ME, Singh J.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6797-800. doi: 10.1016/j.bmcl.2009.09.084. Epub 2009 Sep 27.

PMID:
19836233
7.

Synthesis and structure-activity relationship of 7-azaindole piperidine derivatives as CCR2 antagonists.

Xia M, Hou C, DeMong D, Pollack S, Pan M, Singer M, Matheis M, Murray W, Cavender D, Wachter M.

Bioorg Med Chem Lett. 2008 Dec 15;18(24):6468-70. doi: 10.1016/j.bmcl.2008.10.061. Epub 2008 Oct 17.

PMID:
18990568
8.

Potent heteroarylpiperidine and carboxyphenylpiperidine 1-alkyl-cyclopentane carboxamide CCR2 antagonists.

Pasternak A, Goble SD, Vicario PP, Di Salvo J, Ayala JM, Struthers M, DeMartino JA, Mills SG, Yang L.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):994-8. doi: 10.1016/j.bmcl.2007.12.029. Epub 2007 Dec 27.

PMID:
18164199
9.

Identification of novel series of human CCR1 antagonists.

Xie YF, Sircar I, Lake K, Komandla M, Ligsay K, Li J, Xu K, Parise J, Schneider L, Huang D, Liu J, Sakurai N, Barbosa M, Jack R.

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2215-21. doi: 10.1016/j.bmcl.2007.09.068. Epub 2007 Sep 25.

PMID:
18329267
10.

Synthesis and evaluation of cis-3,4-disubstituted piperidines as potent CC chemokine receptor 2 (CCR2) antagonists.

Cherney RJ, Nelson DJ, Lo YC, Yang G, Scherle PA, Jezak H, Solomon KA, Carter PH, Decicco CP.

Bioorg Med Chem Lett. 2008 Sep 15;18(18):5063-5. doi: 10.1016/j.bmcl.2008.07.123. Epub 2008 Aug 5.

PMID:
18722120
11.

Synthesis and biological evaluation of phenyl piperidine derivatives as CCR2 antagonists.

Xia M, Hou C, Pollack S, Brackley J, DeMong D, Pan M, Singer M, Matheis M, Olini G, Cavender D, Wachter M.

Bioorg Med Chem Lett. 2007 Nov 1;17(21):5964-8. Epub 2007 Aug 21.

PMID:
17869105
12.

Discovery of trisubstituted cyclohexanes as potent CC chemokine receptor 2 (CCR2) antagonists.

Cherney RJ, Brogan JB, Mo R, Lo YC, Yang G, Miller PB, Scherle PA, Molino BF, Carter PH, Decicco CP.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):597-601. doi: 10.1016/j.bmcl.2008.12.062. Epub 2008 Dec 24.

PMID:
19131247
13.

Design, synthesis, and structure-activity relationship of novel CCR2 antagonists.

Kothandaraman S, Donnely KL, Butora G, Jiao R, Pasternak A, Morriello GJ, Goble SD, Zhou C, Mills SG, Maccoss M, Vicario PP, Ayala JM, Demartino JA, Struthers M, Cascieri MA, Yang L.

Bioorg Med Chem Lett. 2009 Mar 15;19(6):1830-4. doi: 10.1016/j.bmcl.2008.12.050. Epub 2008 Dec 24.

PMID:
19237282
14.

Design and synthesis of novel CCR2 antagonists: investigation of non-aryl/heteroaryl binding motifs.

Trujillo JI, Huang W, Hughes RO, Rogier DJ, Turner SR, Devraj R, Morton PA, Xue CB, Chao G, Covington MB, Newton RC, Metcalf B.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1827-31. doi: 10.1016/j.bmcl.2011.01.052. Epub 2011 Jan 21.

PMID:
21316220
15.

In vivo activity of an azole series of CCR2 antagonists.

Smethurst CA, Bevan N, Brooks C, Emmons A, Gough PJ, Mookherjee C, Moores K, Peace S, Philp J, Piercy V, Watson SP, Zippoli M.

Bioorg Med Chem Lett. 2012 Dec 1;22(23):7252-5. doi: 10.1016/j.bmcl.2012.09.020. Epub 2012 Sep 23. Erratum in: Bioorg Med Chem Lett. 2013 Jan 1;23(1):382.

PMID:
23079519
16.

CCR1 and CCR2 antagonists.

Zimmermann HW, Sterzer V, Sahin H.

Curr Top Med Chem. 2014;14(13):1539-52. Review.

PMID:
25159163
17.

6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists.

Orain D, Ofner S, Koller M, Carcache DA, Froestl W, Allgeier H, Rasetti V, Nozulak J, Mattes H, Soldermann N, Floersheim P, Desrayaud S, Kallen J, Lingenhoehl K, Urwyler S.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):996-9. doi: 10.1016/j.bmcl.2011.12.009. Epub 2011 Dec 8.

PMID:
22197388
18.

Synthesis of 3-phenylsulfonylmethyl cyclohexylaminobenzamide-derived antagonists of CC chemokine receptor 2 (CCR2).

Yang MG, Xiao Z, Shi Q, Cherney RJ, Tebben AJ, De Lucca GV, Santella JB 3rd, Mo R, Cvijic ME, Zhao Q, Barrish JC, Carter PH.

Bioorg Med Chem Lett. 2012 Feb 1;22(3):1384-7. doi: 10.1016/j.bmcl.2011.12.057. Epub 2011 Dec 16.

PMID:
22225639
19.

Benzimidazoles as benzamide replacements within cyclohexane-based CC chemokine receptor 2 (CCR2) antagonists.

Cherney RJ, Mo R, Meyer DT, Pechulis AD, Guaciaro MA, Lo YC, Yang G, Miller PB, Scherle PA, Zhao Q, Cvijic ME, Barrish JC, Decicco CP, Carter PH.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6181-4. doi: 10.1016/j.bmcl.2012.08.002. Epub 2012 Aug 10.

PMID:
22939233
20.

Discovery and SAR of 5-aminooctahydrocyclopentapyrrole-3a-carboxamides as potent CCR2 antagonists.

Cai C, McComsey DF, Hou C, O'Neill JC, Opas E, McKenney S, Johnson D, Sui Z.

Bioorg Med Chem Lett. 2014 Feb 15;24(4):1239-42. doi: 10.1016/j.bmcl.2013.05.024. Epub 2013 Jun 28.

PMID:
23916257

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