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Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling.

Maciejowski J, George KA, Terret ME, Zhang C, Shokat KM, Jallepalli PV.

J Cell Biol. 2010 Jul 12;190(1):89-100. doi: 10.1083/jcb.201001050.


Monopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex.

Tipton AR, Ji W, Sturt-Gillespie B, Bekier ME 2nd, Wang K, Taylor WR, Liu ST.

J Biol Chem. 2013 Dec 6;288(49):35149-58. doi: 10.1074/jbc.M113.522375.


Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.

Hewitt L, Tighe A, Santaguida S, White AM, Jones CD, Musacchio A, Green S, Taylor SS.

J Cell Biol. 2010 Jul 12;190(1):25-34. doi: 10.1083/jcb.201002133.


Spindle checkpoint protein dynamics at kinetochores in living cells.

Howell BJ, Moree B, Farrar EM, Stewart S, Fang G, Salmon ED.

Curr Biol. 2004 Jun 8;14(11):953-64.


Regulation of kinetochore recruitment of two essential mitotic spindle checkpoint proteins by Mps1 phosphorylation.

Xu Q, Zhu S, Wang W, Zhang X, Old W, Ahn N, Liu X.

Mol Biol Cell. 2009 Jan;20(1):10-20. doi: 10.1091/mbc.E08-03-0324.


Unattached kinetochores catalyze production of an anaphase inhibitor that requires a Mad2 template to prime Cdc20 for BubR1 binding.

Kulukian A, Han JS, Cleveland DW.

Dev Cell. 2009 Jan;16(1):105-17. doi: 10.1016/j.devcel.2008.11.005.


Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation.

Conde C, Osswald M, Barbosa J, Moutinho-Santos T, Pinheiro D, GuimarĂ£es S, Matos I, Maiato H, Sunkel CE.

EMBO J. 2013 Jun 12;32(12):1761-77. doi: 10.1038/emboj.2013.109.


Release of Mps1 from kinetochores is crucial for timely anaphase onset.

Jelluma N, Dansen TB, Sliedrecht T, Kwiatkowski NP, Kops GJ.

J Cell Biol. 2010 Oct 18;191(2):281-90. doi: 10.1083/jcb.201003038.


Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores.

Tighe A, Staples O, Taylor S.

J Cell Biol. 2008 Jun 16;181(6):893-901. doi: 10.1083/jcb.200712028.


Kinetochore localized Mad2 and Cdc20 is itself insufficient for triggering the mitotic checkpoint when Mps1 is low in Drosophila melanogaster neuroblasts.

Herriott A, Sweeney M, Whitaker M, Taggart M, Huang JY.

Cell Cycle. 2012 Dec 15;11(24):4650-60. doi: 10.4161/cc.22916.


Spatial regulation of the spindle assembly checkpoint and anaphase-promoting complex in Aspergillus nidulans.

Edgerton H, Paolillo V, Oakley BR.

Mol Microbiol. 2015 Feb;95(3):442-57. doi: 10.1111/mmi.12871.


Kinase activity of fission yeast Mph1 is required for Mad2 and Mad3 to stably bind the anaphase promoting complex.

Zich J, Sochaj AM, Syred HM, Milne L, Cook AG, Ohkura H, Rappsilber J, Hardwick KG.

Curr Biol. 2012 Feb 21;22(4):296-301. doi: 10.1016/j.cub.2011.12.049.


Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation.

Maldonado M, Kapoor TM.

Nat Cell Biol. 2011 Apr;13(4):475-82. doi: 10.1038/ncb2223. Erratum in: Nat Cell Biol. 2011 May;13(5):633.


Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine.

Santaguida S, Tighe A, D'Alise AM, Taylor SS, Musacchio A.

J Cell Biol. 2010 Jul 12;190(1):73-87. doi: 10.1083/jcb.201001036.


Dissecting the roles of human BUB1 in the spindle assembly checkpoint.

Vleugel M, Hoek TA, Tromer E, Sliedrecht T, Groenewold V, Omerzu M, Kops GJ.

J Cell Sci. 2015 Aug 15;128(16):2975-82. doi: 10.1242/jcs.169821.


CELL DIVISION CYCLE. Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling.

Hiruma Y, Sacristan C, Pachis ST, Adamopoulos A, Kuijt T, Ubbink M, von Castelmur E, Perrakis A, Kops GJ.

Science. 2015 Jun 12;348(6240):1264-7. doi: 10.1126/science.aaa4055.


Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.

Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS.

J Cell Biol. 2003 Apr 28;161(2):267-80.


Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores.

Liu ST, Chan GK, Hittle JC, Fujii G, Lees E, Yen TJ.

Mol Biol Cell. 2003 Apr;14(4):1638-51.

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