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Items: 1 to 20 of 618

1.

Design, synthesis and anticancer activity of piperazine hydroxamates and their histone deacetylase (HDAC) inhibitory activity.

Chetan B, Bunha M, Jagrat M, Sinha BN, Saiko P, Graser G, Szekeres T, Raman G, Rajendran P, Moorthy D, Basu A, Jayaprakash V.

Bioorg Med Chem Lett. 2010 Jul 1;20(13):3906-10. doi: 10.1016/j.bmcl.2010.05.020. Epub 2010 May 15.

PMID:
20605448
2.

Design, synthesis and preliminary bioactivity studies of 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors.

Guan P, Sun F, Hou X, Wang F, Yi F, Xu W, Fang H.

Bioorg Med Chem. 2012 Jun 15;20(12):3865-72. doi: 10.1016/j.bmc.2012.04.032. Epub 2012 Apr 21.

PMID:
22579621
3.

New aryldithiolethione derivatives as potent histone deacetylase inhibitors.

Tazzari V, Cappelletti G, Casagrande M, Perrino E, Renzi L, Del Soldato P, Sparatore A.

Bioorg Med Chem. 2010 Jun 15;18(12):4187-94. doi: 10.1016/j.bmc.2010.05.011. Epub 2010 May 7.

PMID:
20576572
4.

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.

Rossi C, Porcelloni M, D'Andrea P, Fincham CI, Ettorre A, Mauro S, Squarcia A, Bigioni M, Parlani M, Nardelli F, Binaschi M, Maggi CA, Fattori D.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2305-8. doi: 10.1016/j.bmcl.2011.02.085. Epub 2011 Feb 26.

PMID:
21420859
5.

The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.

Shultz M, Fan J, Chen C, Cho YS, Davis N, Bickford S, Buteau K, Cao X, Holmqvist M, Hsu M, Jiang L, Liu G, Lu Q, Patel C, Suresh JR, Selvaraj M, Urban L, Wang P, Yan-Neale Y, Whitehead L, Zhang H, Zhou L, Atadja P.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4909-12. doi: 10.1016/j.bmcl.2011.06.015.

PMID:
21742496
6.

Synthesis and antitumor activity of novel diaryl ether hydroxamic acids derivatives as potential HDAC inhibitors.

Zhu Y, Chen X, Wu Z, Zheng Y, Chen Y, Tang W, Lu T.

Arch Pharm Res. 2012 Oct;35(10):1723-32. doi: 10.1007/s12272-012-1003-0. Epub 2012 Nov 9.

PMID:
23139122
7.

Inhibitors of human histone deacetylase: synthesis and enzyme assay of hydroxamates with piperazine linker.

Chakrabarty S, Jasmine, Bhadaliya C, Sinha BN, Mahesh A, Bai H, Blond SY, Jayaprakash V.

Arch Pharm (Weinheim). 2010 Mar;343(3):167-72. doi: 10.1002/ardp.200900117.

PMID:
20217840
8.

Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors.

Zhang Y, Feng J, Liu C, Zhang L, Jiao J, Fang H, Su L, Zhang X, Zhang J, Li M, Wang B, Xu W.

Bioorg Med Chem. 2010 Mar 1;18(5):1761-72. doi: 10.1016/j.bmc.2010.01.060. Epub 2010 Feb 6.

PMID:
20171895
9.

Identification of a series of substituted 2-piperazinyl-5-pyrimidylhydroxamic acids as potent histone deacetylase inhibitors.

Angibaud P, Van Emelen K, Decrane L, van Brandt S, Ten Holte P, Pilatte I, Roux B, Poncelet V, Speybrouck D, Queguiner L, Gaurrand S, Mariën A, Floren W, Janssen L, Verdonck M, van Dun J, van Gompel J, Gilissen R, Mackie C, Du Jardin M, Peeters J, Noppe M, Van Hijfte L, Freyne E, Page M, Janicot M, Arts J.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):294-8. doi: 10.1016/j.bmcl.2009.10.118. Epub 2009 Oct 30.

PMID:
19906529
10.

Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylase based on a cinnamic hydroxamic acid core structure.

Chen L, Petrelli R, Gao G, Wilson DJ, McLean GT, Jayaram HN, Sham YY, Pankiewicz KW.

Bioorg Med Chem. 2010 Aug 15;18(16):5950-64. doi: 10.1016/j.bmc.2010.06.081. Epub 2010 Jul 1.

PMID:
20650640
11.

Synthesis and biological characterization of amidopropenyl hydroxamates as HDAC inhibitors.

Thaler F, Varasi M, Colombo A, Boggio R, Munari D, Regalia N, Rozio MG, Reali V, Resconi AE, Mai A, Gagliardi S, Dondio G, Minucci S, Mercurio C.

ChemMedChem. 2010 Aug 2;5(8):1359-72. doi: 10.1002/cmdc.201000166.

PMID:
20572281
12.

Amide-based derivatives of β-alanine hydroxamic acid as histone deacetylase inhibitors: attenuation of potency through resonance effects.

Liao V, Liu T, Codd R.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6200-4. doi: 10.1016/j.bmcl.2012.08.006. Epub 2012 Aug 9.

PMID:
22932316
13.

Synthesis and structure-activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group.

Chen PC, Patil V, Guerrant W, Green P, Oyelere AK.

Bioorg Med Chem. 2008 May 1;16(9):4839-53. doi: 10.1016/j.bmc.2008.03.050. Epub 2008 Mar 23.

PMID:
18397827
14.

Design, synthesis and docking studies on benzamide derivatives as histone deacetylase inhibitors.

Lu A, Luo H, Shi M, Wu G, Yuan Y, Liu J, Tang F.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4924-7. doi: 10.1016/j.bmcl.2011.06.001. Epub 2011 Jun 16.

PMID:
21741834
15.

Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates.

Suzuki T, Nagano Y, Kouketsu A, Matsuura A, Maruyama S, Kurotaki M, Nakagawa H, Miyata N.

J Med Chem. 2005 Feb 24;48(4):1019-32.

PMID:
15715470
16.

Design and synthesis of a new generation of substituted purine hydroxamate analogs as histone deacetylase inhibitors.

Liu R, Wang J, Tang W, Fang H.

Bioorg Med Chem. 2016 Apr 1;24(7):1446-54. doi: 10.1016/j.bmc.2016.02.005. Epub 2016 Feb 6.

PMID:
26907204
17.

Discovery and preliminary evaluation of 2-aminobenzamide and hydroxamate derivatives containing 1,2,4-oxadiazole moiety as potent histone deacetylase inhibitors.

Cai J, Wei H, Hong KH, Wu X, Cao M, Zong X, Li L, Sun C, Chen J, Ji M.

Eur J Med Chem. 2015;96:1-13. doi: 10.1016/j.ejmech.2015.04.002. Epub 2015 Apr 6.

PMID:
25874326
18.

Quinolone-based HDAC inhibitors.

Balasubramanian G, Kilambi N, Rathinasamy S, Rajendran P, Narayanan S, Rajagopal S.

J Enzyme Inhib Med Chem. 2014 Aug;29(4):555-62. doi: 10.3109/14756366.2013.827675. Epub 2013 Sep 9.

PMID:
25019596
19.

Design and synthesis of non-hydroxamate histone deacetylase inhibitors: identification of a selective histone acetylating agent.

Suzuki T, Matsuura A, Kouketsu A, Hisakawa S, Nakagawa H, Miyata N.

Bioorg Med Chem. 2005 Jul 1;13(13):4332-42.

PMID:
15927839
20.

2-aroylindoles and 2-aroylbenzofurans with N-hydroxyacrylamide substructures as a novel series of rationally designed histone deacetylase inhibitors.

Mahboobi S, Sellmer A, Höcher H, Garhammer C, Pongratz H, Maier T, Ciossek T, Beckers T.

J Med Chem. 2007 Sep 6;50(18):4405-18. Epub 2007 Aug 11.

PMID:
17691763

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