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Items: 1 to 20 of 89

1.

Discovery of a proneurogenic, neuroprotective chemical.

Pieper AA, Xie S, Capota E, Estill SJ, Zhong J, Long JM, Becker GL, Huntington P, Goldman SE, Shen CH, Capota M, Britt JK, Kotti T, Ure K, Brat DJ, Williams NS, MacMillan KS, Naidoo J, Melito L, Hsieh J, De Brabander J, Ready JM, McKnight SL.

Cell. 2010 Jul 9;142(1):39-51. doi: 10.1016/j.cell.2010.06.018.

2.

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of Parkinson disease.

De Jesús-Cortés H, Xu P, Drawbridge J, Estill SJ, Huntington P, Tran S, Britt J, Tesla R, Morlock L, Naidoo J, Melito LM, Wang G, Williams NS, Ready JM, McKnight SL, Pieper AA.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17010-5. doi: 10.1073/pnas.1213956109.

3.

Neuroprotective efficacy of a proneurogenic compound after traumatic brain injury.

Blaya MO, Bramlett HM, Naidoo J, Pieper AA, Dietrich WD.

J Neurotrauma. 2014 Mar 1;31(5):476-86. doi: 10.1089/neu.2013.3135.

4.

Chronic P7C3 treatment restores hippocampal neurogenesis in the Ts65Dn mouse model of Down Syndrome [Corrected].

Latchney SE, Jaramillo TC, Rivera PD, Eisch AJ, Powell CM.

Neurosci Lett. 2015 Mar 30;591:86-92. doi: 10.1016/j.neulet.2015.02.008. Erratum in: Neurosci Lett. 2015 Jun 15;597():25.

5.

Development of proneurogenic, neuroprotective small molecules.

MacMillan KS, Naidoo J, Liang J, Melito L, Williams NS, Morlock L, Huntington PJ, Estill SJ, Longgood J, Becker GL, McKnight SL, Pieper AA, De Brabander JK, Ready JM.

J Am Chem Soc. 2011 Feb 9;133(5):1428-37. doi: 10.1021/ja108211m.

6.

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis.

Walker AK, Rivera PD, Wang Q, Chuang JC, Tran S, Osborne-Lawrence S, Estill SJ, Starwalt R, Huntington P, Morlock L, Naidoo J, Williams NS, Ready JM, Eisch AJ, Pieper AA, Zigman JM.

Mol Psychiatry. 2015 Apr;20(4):500-8. doi: 10.1038/mp.2014.34.

7.

Neuroprotective efficacy of aminopropyl carbazoles in a mouse model of amyotrophic lateral sclerosis.

Tesla R, Wolf HP, Xu P, Drawbridge J, Estill SJ, Huntington P, McDaniel L, Knobbe W, Burket A, Tran S, Starwalt R, Morlock L, Naidoo J, Williams NS, Ready JM, McKnight SL, Pieper AA.

Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):17016-21. doi: 10.1073/pnas.1213960109.

8.

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.

Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R.

Nature. 2011 Apr 28;472(7344):466-70. doi: 10.1038/nature09817.

9.

The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice.

Pieper AA, Wu X, Han TW, Estill SJ, Dang Q, Wu LC, Reece-Fincanon S, Dudley CA, Richardson JA, Brat DJ, McKnight SL.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14052-7.

10.

The Neuropsychiatric Disease-Associated Gene cacna1c Mediates Survival of Young Hippocampal Neurons.

Lee AS, De Jesús-Cortés H, Kabir ZD, Knobbe W, Orr M, Burgdorf C, Huntington P, McDaniel L, Britt JK, Hoffmann F, Brat DJ, Rajadhyaksha AM, Pieper AA.

eNeuro. 2016 Mar 31;3(2). pii: ENEURO.0006-16.2016. doi: 10.1523/ENEURO.0006-16.2016.

11.

Aminopropyl carbazole analogues as potent enhancers of neurogenesis.

Yoon HJ, Kong SY, Park MH, Cho Y, Kim SE, Shin JY, Jung S, Lee J, Farhanullah, Kim HJ, Lee J.

Bioorg Med Chem. 2013 Nov 15;21(22):7165-74. doi: 10.1016/j.bmc.2013.08.066. Erratum in: Bioorg Med Chem. 2014 Jan 15;22(2):927.

PMID:
24095011
12.

Genetic manipulation of adult-born hippocampal neurons rescues memory in a mouse model of Alzheimer's disease.

Richetin K, Leclerc C, Toni N, Gallopin T, Pech S, Roybon L, Rampon C.

Brain. 2015 Feb;138(Pt 2):440-55. doi: 10.1093/brain/awu354.

PMID:
25518958
13.

Transcriptional regulation of neurodevelopmental and metabolic pathways by NPAS3.

Sha L, MacIntyre L, Machell JA, Kelly MP, Porteous DJ, Brandon NJ, Muir WJ, Blackwood DH, Watson DG, Clapcote SJ, Pickard BS.

Mol Psychiatry. 2012 Mar;17(3):267-79. doi: 10.1038/mp.2011.73.

PMID:
21709683
14.

Krüppel-like factor 9 is necessary for late-phase neuronal maturation in the developing dentate gyrus and during adult hippocampal neurogenesis.

Scobie KN, Hall BJ, Wilke SA, Klemenhagen KC, Fujii-Kuriyama Y, Ghosh A, Hen R, Sahay A.

J Neurosci. 2009 Aug 5;29(31):9875-87. doi: 10.1523/JNEUROSCI.2260-09.2009.

15.

Androgens increase survival of adult-born neurons in the dentate gyrus by an androgen receptor-dependent mechanism in male rats.

Hamson DK, Wainwright SR, Taylor JR, Jones BA, Watson NV, Galea LA.

Endocrinology. 2013 Sep;154(9):3294-304. doi: 10.1210/en.2013-1129.

PMID:
23782943
16.

Induction of neurogenesis in the adult dentate gyrus by cortical spreading depression.

Urbach A, Redecker C, Witte OW.

Stroke. 2008 Nov;39(11):3064-72. doi: 10.1161/STROKEAHA.108.518076.

17.

Endogenous signaling through alpha7-containing nicotinic receptors promotes maturation and integration of adult-born neurons in the hippocampus.

Campbell NR, Fernandes CC, Halff AW, Berg DK.

J Neurosci. 2010 Jun 30;30(26):8734-44. doi: 10.1523/JNEUROSCI.0931-10.2010.

18.

Discovery of a neuroprotective chemical, (S)-N-(3-(3,6-dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(-)-P7C3-S243], with improved druglike properties.

Naidoo J, De Jesus-Cortes H, Huntington P, Estill S, Morlock LK, Starwalt R, Mangano TJ, Williams NS, Pieper AA, Ready JM.

J Med Chem. 2014 May 8;57(9):3746-54. doi: 10.1021/jm401919s.

19.

Melatonin supplementation delays the decline of adult hippocampal neurogenesis during normal aging of mice.

Ramírez-Rodríguez G, Vega-Rivera NM, Benítez-King G, Castro-García M, Ortíz-López L.

Neurosci Lett. 2012 Nov 14;530(1):53-8. doi: 10.1016/j.neulet.2012.09.045.

PMID:
23043890
20.

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