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Items: 1 to 20 of 98


Pharmacologic resuscitation promotes survival and attenuates hemorrhage-induced activation of extracellular signal-regulated kinase 1/2.

Fukudome EY, Kochanek AR, Li Y, Smith EJ, Liu B, Kheirbek T, Lu J, Kim K, Hamwi K, Velmahos GC, Alam HB.

J Surg Res. 2010 Sep;163(1):118-26. doi: 10.1016/j.jss.2010.04.013. Epub 2010 May 7.


Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock.

Butt MU, Sailhamer EA, Li Y, Liu B, Shuja F, Velmahos GC, DeMoya M, King DR, Alam HB.

J Surg Res. 2009 Oct;156(2):290-6. doi: 10.1016/j.jss.2009.04.012. Epub 2009 May 13.


Histone deacetylase inhibitor treatment attenuates MAP kinase pathway activation and pulmonary inflammation following hemorrhagic shock in a rodent model.

Kochanek AR, Fukudome EY, Li Y, Smith EJ, Liu B, Velmahos GC, deMoya M, King D, Alam HB.

J Surg Res. 2012 Jul;176(1):185-94. doi: 10.1016/j.jss.2011.06.007. Epub 2011 Jul 5.


Histone deacetylase inhibitors prevent apoptosis following lethal hemorrhagic shock in rodent kidney cells.

Zacharias N, Sailhamer EA, Li Y, Liu B, Butt MU, Shuja F, Velmahos GC, de Moya M, Alam HB.

Resuscitation. 2011 Jan;82(1):105-9. doi: 10.1016/j.resuscitation.2010.09.469. Epub 2010 Oct 30.


Valproic acid for the treatment of hemorrhagic shock: a dose-optimization study.

Hwabejire JO, Lu J, Liu B, Li Y, Halaweish I, Alam HB.

J Surg Res. 2014 Jan;186(1):363-70. doi: 10.1016/j.jss.2013.09.016. Epub 2013 Oct 5.


Histone deacetylase as therapeutic target in a rodent model of hemorrhagic shock: effect of different resuscitation strategies on lung and liver.

Lin T, Chen H, Koustova E, Sailhamer EA, Li Y, Shults C, Liu B, Rhee P, Kirkpatrick J, Alam HB.

Surgery. 2007 Jun;141(6):784-94.


Hepatoprotection and lethality rescue by histone deacetylase inhibitor valproic acid in fatal hemorrhagic shock.

Gonzales ER, Chen H, Munuve RM, Mehrani T, Nadel A, Koustova E.

J Trauma. 2008 Sep;65(3):554-65. doi: 10.1097/TA.0b013e31818233ef.


Pharmacologic resuscitation decreases circulating cytokine-induced neutrophil chemoattractant-1 levels and attenuates hemorrhage-induced acute lung injury.

Fukudome EY, Li Y, Kochanek AR, Lu J, Smith EJ, Liu B, Kim K, Velmahos GC, deMoya MA, Alam HB.

Surgery. 2012 Aug;152(2):254-61. doi: 10.1016/j.surg.2012.03.013. Epub 2012 May 30.


Creating a prosurvival phenotype through a histone deacetylase inhibitor in a lethal two-hit model.

Liu Z, Li Y, Chong W, Deperalta DK, Duan X, Liu B, Halaweish I, Zhou P, Alam HB.

Shock. 2014 Feb;41(2):104-8. doi: 10.1097/SHK.0000000000000074.


Surviving blood loss without fluid resuscitation.

Shults C, Sailhamer EA, Li Y, Liu B, Tabbara M, Butt MU, Shuja F, Demoya M, Velmahos G, Alam HB.

J Trauma. 2008 Mar;64(3):629-38; discussion 638-40. doi: 10.1097/TA.0b013e3181650ff3.


Surviving blood loss without blood transfusion in a swine poly-trauma model.

Alam HB, Shuja F, Butt MU, Duggan M, Li Y, Zacharias N, Fukudome EY, Liu B, Demoya M, Velmahos GC.

Surgery. 2009 Aug;146(2):325-33. doi: 10.1016/j.surg.2009.04.007. Epub 2009 Jun 25.


[The effects of administration of valproic acid on organ function and outcome in a canine lethal hemorrhagic shock model].

Hu S, Hou JY, Li L, Yang MX, Sheng ZY.

Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2011 Aug;23(8):471-4. Chinese.


Valproic acid-mediated myocardial protection of acute hemorrhagic rat via the BCL-2 pathway.

Wang C, Wang Y, Qiao Z, Kuai Q, Wang Y, Wang X, He M, Li W, He Y, Ren S, Yu Q.

J Trauma Acute Care Surg. 2016 May;80(5):812-8. doi: 10.1097/TA.0000000000000987.


Identification of a novel potential biomarker in a model of hemorrhagic shock and valproic acid treatment.

Li Y, Liu B, Dillon ST, Fukudome EY, Kheirbek T, Sailhamer EA, Velmahos G, deMoya M, Libermann TA, Alam HB.

J Surg Res. 2010 Mar;159(1):474-81. doi: 10.1016/j.jss.2009.04.011. Epub 2009 May 13.


Role of extracellular signal-regulated protein kinase (ERK) in 17beta-estradiol-mediated attenuation of lung injury after trauma-hemorrhage.

Hsu JT, Kan WH, Hsieh CH, Choudhry MA, Bland KI, Chaudry IH.

Surgery. 2009 Feb;145(2):226-34. doi: 10.1016/j.surg.2008.10.008. Epub 2008 Dec 23.


Hypothermia and valproic acid activate prosurvival pathways after hemorrhage.

Bambakidis T, Dekker SE, Liu B, Maxwell J, Chtraklin K, Linzel D, Li Y, Alam HB.

J Surg Res. 2015 Jun 1;196(1):159-65. doi: 10.1016/j.jss.2015.02.036. Epub 2015 Feb 19.


Selective inhibition of histone deacetylase 6 promotes survival in a rat model of hemorrhagic shock.

Chang Z, Li Y, He W, Liu B, Halaweish I, Bambakidis T, Liang Y, Alam HB.

J Trauma Acute Care Surg. 2015 Dec;79(6):905-10. doi: 10.1097/TA.0000000000000784.


Beneficial effects of histone deacetylase inhibition with severe hemorrhage and ischemia-reperfusion injury.

Causey MW, Miller S, Hoffer Z, Hempel J, Stallings JD, Jin G, Alam H, Martin M.

J Surg Res. 2013 Sep;184(1):533-40. doi: 10.1016/j.jss.2013.03.087. Epub 2013 Apr 17.


HDACi Valproic Acid (VPA) and Suberoylanilide Hydroxamic Acid (SAHA) Delay but Fail to Protect against Warm Hepatic Ischemia-Reperfusion Injury.

Ruess DA, Probst M, Marjanovic G, Wittel UA, Hopt UT, Keck T, Bausch D.

PLoS One. 2016 Aug 11;11(8):e0161233. doi: 10.1371/journal.pone.0161233. eCollection 2016.


Cell protective mechanism of valproic acid in lethal hemorrhagic shock.

Li Y, Liu B, Sailhamer EA, Yuan Z, Shults C, Velmahos GC, deMoya M, Shuja F, Butt MU, Alam HB.

Surgery. 2008 Aug;144(2):217-24. doi: 10.1016/j.surg.2008.03.037.


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