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Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer.

Cocco E, Casagrande F, Bellone S, Richter CE, Bellone M, Todeschini P, Holmberg JC, Fu HH, Montagna MK, Mor G, Schwartz PE, Arin-Silasi D, Azoudi M, Rutherford TJ, Abu-Khalaf M, Pecorelli S, Santin AD.

BMC Cancer. 2010 Jul 2;10:349. doi: 10.1186/1471-2407-10-349.


Treatment of chemotherapy-resistant human ovarian cancer xenografts in C.B-17/SCID mice by intraperitoneal administration of Clostridium perfringens enterotoxin.

Santin AD, Cané S, Bellone S, Palmieri M, Siegel ER, Thomas M, Roman JJ, Burnett A, Cannon MJ, Pecorelli S.

Cancer Res. 2005 May 15;65(10):4334-42.


Overexpression of claudin-3 and claudin-4 receptors in uterine serous papillary carcinoma: novel targets for a type-specific therapy using Clostridium perfringens enterotoxin (CPE).

Santin AD, Bellone S, Marizzoni M, Palmieri M, Siegel ER, McKenney JK, Hennings L, Comper F, Bandiera E, Pecorelli S.

Cancer. 2007 Apr 1;109(7):1312-22.


Eradication of chemotherapy-resistant CD44+ human ovarian cancer stem cells in mice by intraperitoneal administration of Clostridium perfringens enterotoxin.

Casagrande F, Cocco E, Bellone S, Richter CE, Bellone M, Todeschini P, Siegel E, Varughese J, Arin-Silasi D, Azodi M, Rutherford TJ, Pecorelli S, Schwartz PE, Santin AD.

Cancer. 2011 Dec 15;117(24):5519-28. doi: 10.1002/cncr.26215. Epub 2011 Jun 20.


Clostridium perfringens enterotoxin C-terminal domain labeled to fluorescent dyes for in vivo visualization of micrometastatic chemotherapy-resistant ovarian cancer.

Cocco E, Shapiro EM, Gasparrini S, Lopez S, Schwab CL, Bellone S, Bortolomai I, Sumi NJ, Bonazzoli E, Nicoletti R, Deng Y, Saltzman WM, Zeiss CJ, Centritto F, Black JD, Silasi DA, Ratner E, Azodi M, Rutherford TJ, Schwartz PE, Pecorelli S, Santin AD.

Int J Cancer. 2015 Dec 1;137(11):2618-29. doi: 10.1002/ijc.29632. Epub 2015 Aug 18.


Overexpression of epithelial cell adhesion molecule in primary, metastatic, and recurrent/chemotherapy-resistant epithelial ovarian cancer: implications for epithelial cell adhesion molecule-specific immunotherapy.

Bellone S, Siegel ER, Cocco E, Cargnelutti M, Silasi DA, Azodi M, Schwartz PE, Rutherford TJ, Pecorelli S, Santin AD.

Int J Gynecol Cancer. 2009 Jul;19(5):860-6. doi: 10.1111/IGC.0b013e3181a8331f.


Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium.

Long H, Crean CD, Lee WH, Cummings OW, Gabig TG.

Cancer Res. 2001 Nov 1;61(21):7878-81.


Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells.

Cocco E, Deng Y, Shapiro EM, Bortolomai I, Lopez S, Lin K, Bellone S, Cui J, Menderes G, Black JD, Schwab CL, Bonazzoli E, Yang F, Predolini F, Zammataro L, Altwerger G, de Haydu C, Clark M, Alvarenga J, Ratner E, Azodi M, Silasi DA, Schwartz PE, Litkouhi B, Saltzman WM, Santin AD.

Mol Cancer Ther. 2017 Feb;16(2):323-333. doi: 10.1158/1535-7163.MCT-16-0501. Epub 2016 Dec 12.


Claudin-4 overexpression in epithelial ovarian cancer is associated with hypomethylation and is a potential target for modulation of tight junction barrier function using a C-terminal fragment of Clostridium perfringens enterotoxin.

Litkouhi B, Kwong J, Lo CM, Smedley JG 3rd, McClane BA, Aponte M, Gao Z, Sarno JL, Hinners J, Welch WR, Berkowitz RS, Mok SC, Garner EI.

Neoplasia. 2007 Apr;9(4):304-14.


Tissue distribution and safety evaluation of a claudin-targeting molecule, the C-terminal fragment of Clostridium perfringens enterotoxin.

Li X, Saeki R, Watari A, Yagi K, Kondoh M.

Eur J Pharm Sci. 2014 Feb 14;52:132-7. doi: 10.1016/j.ejps.2013.10.018. Epub 2013 Nov 11.


Clostridium perfringens enterotoxin as a potential drug for intravesical treatment of bladder cancer.

Gabig TG, Waltzer WC, Whyard T, Romanov V.

Biochem Biophys Res Commun. 2016 Sep 16;478(2):887-92. doi: 10.1016/j.bbrc.2016.08.046. Epub 2016 Aug 9.


C terminus of Clostridium perfringens enterotoxin downregulates CLDN4 and sensitizes ovarian cancer cells to Taxol and Carboplatin.

Gao Z, Xu X, McClane B, Zeng Q, Litkouhi B, Welch WR, Berkowitz RS, Mok SC, Garner EI.

Clin Cancer Res. 2011 Mar 1;17(5):1065-74. doi: 10.1158/1078-0432.CCR-10-1644. Epub 2010 Dec 1.


Claudin-4: a new target for pancreatic cancer treatment using Clostridium perfringens enterotoxin.

Michl P, Buchholz M, Rolke M, Kunsch S, Löhr M, McClane B, Tsukita S, Leder G, Adler G, Gress TM.

Gastroenterology. 2001 Sep;121(3):678-84.


Recombinant CPE fused to tumor necrosis factor targets human ovarian cancer cells expressing the claudin-3 and claudin-4 receptors.

Yuan X, Lin X, Manorek G, Kanatani I, Cheung LH, Rosenblum MG, Howell SB.

Mol Cancer Ther. 2009 Jul;8(7):1906-15. doi: 10.1158/1535-7163.MCT-09-0106. Epub 2009 Jun 30.


Overexpression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in uterine carcinosarcomas.

Santin AD, Bellone S, Siegel ER, McKenney JK, Thomas M, Roman JJ, Burnett A, Tognon G, Bandiera E, Pecorelli S.

Clin Cancer Res. 2007 Jun 1;13(11):3339-46.


Preparation of a claudin-targeting molecule using a C-terminal fragment of Clostridium perfringens enterotoxin.

Ebihara C, Kondoh M, Hasuike N, Harada M, Mizuguchi H, Horiguchi Y, Fujii M, Watanabe Y.

J Pharmacol Exp Ther. 2006 Jan;316(1):255-60. Epub 2005 Sep 23.


Epidermal growth factor modulates claudins and tight junctional functions in ovarian cancer cell lines.

Ogawa M, Kojima T, Someya M, Nomura K, Takasawa A, Murata M, Tanaka S, Saito T, Sawada N.

Histochem Cell Biol. 2012 Aug;138(2):323-38. doi: 10.1007/s00418-012-0956-x. Epub 2012 Apr 29.


Claudins overexpression in ovarian cancer: potential targets for Clostridium Perfringens Enterotoxin (CPE) based diagnosis and therapy.

English DP, Santin AD.

Int J Mol Sci. 2013 May 17;14(5):10412-37. doi: 10.3390/ijms140510412. Review.


Molecular cloning and functional characterization of the receptor for Clostridium perfringens enterotoxin.

Katahira J, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N.

J Cell Biol. 1997 Mar 24;136(6):1239-47.


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