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Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter.

Hannigan A, Smith P, Kalna G, Lo Nigro C, Orange C, O'Brien DI, Shah R, Syed N, Spender LC, Herrera B, Thurlow JK, Lattanzio L, Monteverde M, Maurer ME, Buffa FM, Mann J, Chu DC, West CM, Patridge M, Oien KA, Cooper JA, Frame MC, Harris AL, Hiller L, Nicholson LJ, Gasco M, Crook T, Inman GJ.

J Clin Invest. 2010 Aug;120(8):2842-57. doi: 10.1172/JCI36125. Epub 2010 Jul 1.


MicroRNA-106b is involved in transforming growth factor β1-induced cell migration by targeting disabled homolog 2 in cervical carcinoma.

Cheng Y, Guo Y, Zhang Y, You K, Li Z, Geng L.

J Exp Clin Cancer Res. 2016 Jan 15;35:11. doi: 10.1186/s13046-016-0290-6.


Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-β (TGF-β).

Lin S, Yu L, Yang J, Liu Z, Karia B, Bishop AJ, Jackson J, Lozano G, Copland JA, Mu X, Sun B, Sun LZ.

J Biol Chem. 2011 Dec 23;286(51):44023-34. doi: 10.1074/jbc.M111.265397. Epub 2011 Oct 28.


Loss of disabled-2 expression is an early event in esophageal squamous tumorigenesis.

Anupam K, Tusharkant C, Gupta SD, Ranju R.

World J Gastroenterol. 2006 Oct 7;12(37):6041-5.


Reduced expression of transcriptional intermediary factor 1 gamma promotes metastasis and indicates poor prognosis of hepatocellular carcinoma.

Ding ZY, Jin GN, Wang W, Chen WX, Wu YH, Ai X, Chen L, Zhang WG, Liang HF, Laurence A, Zhang MZ, Datta PK, Zhang B, Chen XP.

Hepatology. 2014 Nov;60(5):1620-36. doi: 10.1002/hep.27273. Epub 2014 Sep 25.


Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity.

Hjelmeland AB, Hjelmeland MD, Shi Q, Hart JL, Bigner DD, Wang XF, Kontos CD, Rich JN.

Cancer Res. 2005 Dec 15;65(24):11276-81.


Activation of Smad signaling enhances collagenase-3 (MMP-13) expression and invasion of head and neck squamous carcinoma cells.

Leivonen SK, Ala-Aho R, Koli K, Grénman R, Peltonen J, Kähäri VM.

Oncogene. 2006 Apr 27;25(18):2588-600.


Putative tumour-suppressor gene DAB2 is frequently down regulated by promoter hypermethylation in nasopharyngeal carcinoma.

Tong JH, Ng DC, Chau SL, So KK, Leung PP, Lee TL, Lung RW, Chan MW, Chan AW, Lo KW, To KF.

BMC Cancer. 2010 Jun 3;10:253. doi: 10.1186/1471-2407-10-253.


miR-93-directed downregulation of DAB2 defines a novel oncogenic pathway in lung cancer.

Du L, Zhao Z, Ma X, Hsiao TH, Chen Y, Young E, Suraokar M, Wistuba I, Minna JD, Pertsemlidis A.

Oncogene. 2014 Aug 21;33(34):4307-15. doi: 10.1038/onc.2013.381. Epub 2013 Sep 16.


Expression and clinical significance of the transforming growth factor-β signalling pathway in endometrial cancer.

Mhawech-Fauceglia P, Kesterson J, Wang D, Akers S, Dupont NC, Clark K, Lele S, Liu S.

Histopathology. 2011 Jul;59(1):63-72. doi: 10.1111/j.1365-2559.2011.03892.x.


Aberrant hypermethylation and reduced expression of disabled-2 promote the development of lung cancers.

Xie XM, Zhang ZY, Yang LH, Yang DL, Tang N, Zhao HY, Xu HT, Li QC, Wang EH.

Int J Oncol. 2013 Nov;43(5):1636-42. doi: 10.3892/ijo.2013.2084. Epub 2013 Aug 29.


Gene methylation in gastric cancer.

Qu Y, Dang S, Hou P.

Clin Chim Acta. 2013 Sep 23;424:53-65. doi: 10.1016/j.cca.2013.05.002. Epub 2013 May 10. Review.


Dab2 inhibits the cholesterol-dependent activation of JNK by TGF-β.

Shapira KE, Hirschhorn T, Barzilay L, Smorodinsky NI, Henis YI, Ehrlich M.

Mol Biol Cell. 2014 May;25(10):1620-8. doi: 10.1091/mbc.E13-09-0537. Epub 2014 Mar 19.


Promoter hypermethylation of FBXO32, a novel TGF-beta/SMAD4 target gene and tumor suppressor, is associated with poor prognosis in human ovarian cancer.

Chou JL, Su HY, Chen LY, Liao YP, Hartman-Frey C, Lai YH, Yang HW, Deatherage DE, Kuo CT, Huang YW, Yan PS, Hsiao SH, Tai CK, Lin HJ, Davuluri RV, Chao TK, Nephew KP, Huang TH, Lai HC, Chan MW.

Lab Invest. 2010 Mar;90(3):414-25. doi: 10.1038/labinvest.2009.138. Epub 2010 Jan 11.


Regulation of ovarian cancer progression by microRNA-187 through targeting Disabled homolog-2.

Chao A, Lin CY, Lee YS, Tsai CL, Wei PC, Hsueh S, Wu TI, Tsai CN, Wang CJ, Chao AS, Wang TH, Lai CH.

Oncogene. 2012 Feb 9;31(6):764-75. doi: 10.1038/onc.2011.269. Epub 2011 Jul 4.


Critical role of Smad2 in tumor suppression and transforming growth factor-beta-induced apoptosis of prostate epithelial cells.

Yang J, Wahdan-Alaswad R, Danielpour D.

Cancer Res. 2009 Mar 15;69(6):2185-90. doi: 10.1158/0008-5472.CAN-08-3961. Epub 2009 Mar 10.

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