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Items: 1 to 20 of 375

1.

Targeting epidermal growth factor receptor-associated signaling pathways in non-small cell lung cancer cells: implication in radiation response.

Choi EJ, Ryu YK, Kim SY, Wu HG, Kim JS, Kim IH, Kim IA.

Mol Cancer Res. 2010 Jul;8(7):1027-36. doi: 10.1158/1541-7786.MCR-09-0507. Epub 2010 Jun 29.

2.

Effect of rapamycin, an mTOR inhibitor, on radiation sensitivity of lung cancer cells having different p53 gene status.

Nagata Y, Takahashi A, Ohnishi K, Ota I, Ohnishi T, Tojo T, Taniguchi S.

Int J Oncol. 2010 Oct;37(4):1001-10.

PMID:
20811722
3.

Inhibition of PI3 kinases enhances the sensitivity of non-small cell lung cancer cells to ionizing radiation.

Zhang T, Cui GB, Zhang J, Zhang F, Zhou YA, Jiang T, Li XF.

Oncol Rep. 2010 Dec;24(6):1683-9.

PMID:
21042768
4.

Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.

Carón RW, Yacoub A, Li M, Zhu X, Mitchell C, Hong Y, Hawkins W, Sasazuki T, Shirasawa S, Kozikowski AP, Dennis PA, Hagan MP, Grant S, Dent P.

Mol Cancer Ther. 2005 Feb;4(2):257-70.

5.

H-RAS V12-induced radioresistance in HCT116 colon carcinoma cells is heregulin dependent.

Carón RW, Yacoub A, Zhu X, Mitchell C, Han SI, Sasazuki T, Shirasawa S, Hagan MP, Grant S, Dent P.

Mol Cancer Ther. 2005 Feb;4(2):243-55.

6.

Radioresistance of K-Ras mutated human tumor cells is mediated through EGFR-dependent activation of PI3K-AKT pathway.

Toulany M, Dittmann K, Krüger M, Baumann M, Rodemann HP.

Radiother Oncol. 2005 Aug;76(2):143-50.

PMID:
16024124
7.

Effects of the EGFR/HER2 kinase inhibitor GW572016 on EGFR- and HER2-overexpressing breast cancer cell line proliferation, radiosensitization, and resistance.

Zhou H, Kim YS, Peletier A, McCall W, Earp HS, Sartor CI.

Int J Radiat Oncol Biol Phys. 2004 Feb 1;58(2):344-52.

PMID:
14751502
8.

Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA-repair: a COX-2 independent mechanism.

Dittmann KH, Mayer C, Ohneseit PA, Raju U, Andratschke NH, Milas L, Rodemann HP.

Int J Radiat Oncol Biol Phys. 2008 Jan 1;70(1):203-12. Epub 2007 Nov 8.

PMID:
17996386
9.

Targeting the Akt/mammalian target of rapamycin pathway for radiosensitization of breast cancer.

Albert JM, Kim KW, Cao C, Lu B.

Mol Cancer Ther. 2006 May;5(5):1183-9.

10.

Lovastatin inhibits EGFR dimerization and AKT activation in squamous cell carcinoma cells: potential regulation by targeting rho proteins.

Zhao TT, Le Francois BG, Goss G, Ding K, Bradbury PA, Dimitroulakos J.

Oncogene. 2010 Aug 19;29(33):4682-92. doi: 10.1038/onc.2010.219. Epub 2010 Jun 21.

PMID:
20562912
11.

K-RAS(V12) induces autocrine production of EGFR ligands and mediates radioresistance through EGFR-dependent Akt signaling and activation of DNA-PKcs.

Minjgee M, Toulany M, Kehlbach R, Giehl K, Rodemann HP.

Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):1506-14. doi: 10.1016/j.ijrobp.2011.05.057. Epub 2011 Oct 8.

PMID:
21985943
12.

Targeting HER2 signaling pathway for radiosensitization: alternative strategy for therapeutic resistance.

No M, Choi EJ, Kim IA.

Cancer Biol Ther. 2009 Dec;8(24):2351-61. Epub 2009 Dec 19.

PMID:
19923913
13.
14.

Targeted therapies for non-small-cell lung cancer: biology, rationale, and preclinical results from a radiation oncology perspective.

Raben D, Helfrich B, Bunn PA Jr.

Int J Radiat Oncol Biol Phys. 2004;59(2 Suppl):27-38. Review.

PMID:
15142632
15.

PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro.

Toulany M, Dittmann K, Fehrenbacher B, Schaller M, Baumann M, Rodemann HP.

DNA Repair (Amst). 2008 Oct 1;7(10):1746-56. doi: 10.1016/j.dnarep.2008.06.017. Epub 2008 Aug 22.

PMID:
18678286
16.

Combined inhibition of the EGFR and mTOR pathways in EGFR wild-type non-small cell lung cancer cell lines with different genetic backgrounds.

Huang Y, Chen Y, Mei Q, Chen Y, Yu S, Xia S.

Oncol Rep. 2013 Jun;29(6):2486-92. doi: 10.3892/or.2013.2357. Epub 2013 Mar 22.

PMID:
23525575
18.

Sensitization to gamma-irradiation-induced cell cycle arrest and apoptosis by the histone deacetylase inhibitor trichostatin A in non-small cell lung cancer (NSCLC) cells.

Zhang F, Zhang T, Teng ZH, Zhang R, Wang JB, Mei QB.

Cancer Biol Ther. 2009 May;8(9):823-31. Epub 2009 May 10.

PMID:
19270532
19.

Dependence on phosphoinositide 3-kinase and RAS-RAF pathways drive the activity of RAF265, a novel RAF/VEGFR2 inhibitor, and RAD001 (Everolimus) in combination.

Mordant P, Loriot Y, Leteur C, Calderaro J, Bourhis J, Wislez M, Soria JC, Deutsch E.

Mol Cancer Ther. 2010 Feb;9(2):358-68. doi: 10.1158/1535-7163.MCT-09-1014. Epub 2010 Feb 2.

20.

Radiosensitization of epidermal growth factor receptor/HER2-positive pancreatic cancer is mediated by inhibition of Akt independent of ras mutational status.

Kimple RJ, Vaseva AV, Cox AD, Baerman KM, Calvo BF, Tepper JE, Shields JM, Sartor CI.

Clin Cancer Res. 2010 Feb 1;16(3):912-23. doi: 10.1158/1078-0432.CCR-09-1324. Epub 2010 Jan 26.

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