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Items: 1 to 20 of 156


The Werner syndrome protein suppresses telomeric instability caused by chromium (VI) induced DNA replication stress.

Liu FJ, Barchowsky A, Opresko PL.

PLoS One. 2010 Jun 16;5(6):e11152. doi: 10.1371/journal.pone.0011152.


The Werner syndrome protein functions in repair of Cr(VI)-induced replication-associated DNA damage.

Liu FJ, Barchowsky A, Opresko PL.

Toxicol Sci. 2009 Aug;110(2):307-18. doi: 10.1093/toxsci/kfp104. Epub 2009 Jun 1.


WRN controls formation of extrachromosomal telomeric circles and is required for TRF2DeltaB-mediated telomere shortening.

Li B, Jog SP, Reddy S, Comai L.

Mol Cell Biol. 2008 Mar;28(6):1892-904. doi: 10.1128/MCB.01364-07. Epub 2008 Jan 22.


Roles of the Werner syndrome RecQ helicase in DNA replication.

Sidorova JM.

DNA Repair (Amst). 2008 Nov 1;7(11):1776-86. doi: 10.1016/j.dnarep.2008.07.017. Epub 2008 Sep 6. Review.


Telomere dysfunction as a cause of genomic instability in Werner syndrome.

Crabbe L, Jauch A, Naeger CM, Holtgreve-Grez H, Karlseder J.

Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2205-10. Epub 2007 Feb 6.


WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.

Zecevic A, Menard H, Gurel V, Hagan E, DeCaro R, Zhitkovich A.

Cell Cycle. 2009 Sep 1;8(17):2769-78. Epub 2009 Sep 2.


Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences.

Damerla RR, Knickelbein KE, Strutt S, Liu FJ, Wang H, Opresko PL.

Cell Cycle. 2012 Aug 15;11(16):3036-44. doi: 10.4161/cc.21399. Epub 2012 Aug 8.


The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.

Opresko PL, Otterlei M, Graakjaer J, Bruheim P, Dawut L, Kølvraa S, May A, Seidman MM, Bohr VA.

Mol Cell. 2004 Jun 18;14(6):763-74.


Defective telomere lagging strand synthesis in cells lacking WRN helicase activity.

Crabbe L, Verdun RE, Haggblom CI, Karlseder J.

Science. 2004 Dec 10;306(5703):1951-3.


Telomere instability in a human tumor cell line expressing a dominant-negative WRN protein.

Bai Y, Murnane JP.

Hum Genet. 2003 Sep;113(4):337-47. Epub 2003 Jun 25.


The roles of WRN and BLM RecQ helicases in the Alternative Lengthening of Telomeres.

Mendez-Bermudez A, Hidalgo-Bravo A, Cotton VE, Gravani A, Jeyapalan JN, Royle NJ.

Nucleic Acids Res. 2012 Nov;40(21):10809-20. doi: 10.1093/nar/gks862. Epub 2012 Sep 18.


Telomere ResQue and preservation--roles for the Werner syndrome protein and other RecQ helicases.

Opresko PL.

Mech Ageing Dev. 2008 Jan-Feb;129(1-2):79-90. Epub 2007 Oct 30. Review.


WRN loss induces switching of telomerase-independent mechanisms of telomere elongation.

Gocha AR, Acharya S, Groden J.

PLoS One. 2014 Apr 7;9(4):e93991. doi: 10.1371/journal.pone.0093991. eCollection 2014.


Werner protein protects nonproliferating cells from oxidative DNA damage.

Szekely AM, Bleichert F, Nümann A, Van Komen S, Manasanch E, Ben Nasr A, Canaan A, Weissman SM.

Mol Cell Biol. 2005 Dec;25(23):10492-506.


A role for WRN in telomere-based DNA damage responses.

Eller MS, Liao X, Liu S, Hanna K, Bäckvall H, Opresko PL, Bohr VA, Gilchrest BA.

Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15073-8. Epub 2006 Oct 2.


Coordinate action of the helicase and 3' to 5' exonuclease of Werner syndrome protein.

Opresko PL, Laine JP, Brosh RM Jr, Seidman MM, Bohr VA.

J Biol Chem. 2001 Nov 30;276(48):44677-87. Epub 2001 Sep 25.


Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases.

Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA.

J Biol Chem. 2002 Oct 25;277(43):41110-9. Epub 2002 Aug 13.


The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures.

Barefield C, Karlseder J.

Nucleic Acids Res. 2012 Aug;40(15):7358-67. doi: 10.1093/nar/gks407. Epub 2012 May 10.


Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress.

Aggarwal M, Sommers JA, Shoemaker RH, Brosh RM Jr.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1525-30. doi: 10.1073/pnas.1006423108. Epub 2011 Jan 10.

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