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Items: 1 to 20 of 72

1.

Early events in vascular injury in the rat induced by the phosphodiesterase IV inhibitor SCH 351591.

Weaver JL, Zhang J, Knapton A, Miller T, Espandiari P, Smith R, Gu YZ, Snyder RD.

Toxicol Pathol. 2010 Aug;38(5):738-44. doi: 10.1177/0192623310374331. Epub 2010 Jun 28.

PMID:
20585143
2.

Histopathology of vascular injury in Sprague-Dawley rats treated with phosphodiesterase IV inhibitor SCH 351591 or SCH 534385.

Zhang J, Snyder RD, Herman EH, Knapton A, Honchel R, Miller T, Espandiari P, Goodsaid FM, Rosenblum IY, Hanig JP, Sistare FD, Weaver JL.

Toxicol Pathol. 2008 Oct;36(6):827-39. doi: 10.1177/0192623308322308. Epub 2008 Sep 5.

PMID:
18776163
3.

Biomarkers in peripheral blood associated with vascular injury in Sprague-Dawley rats treated with the phosphodiesterase IV inhibitors SCH 351591 or SCH 534385.

Weaver JL, Snyder R, Knapton A, Herman EH, Honchel R, Miller T, Espandiari P, Smith R, Gu YZ, Goodsaid FM, Rosenblum IY, Sistare FD, Zhang J, Hanig J.

Toxicol Pathol. 2008 Oct;36(6):840-9. doi: 10.1177/0192623308322310. Epub 2008 Sep 5.

PMID:
18776166
4.

Effects of modulating in vivo nitric oxide production on the incidence and severity of PDE4 inhibitor-induced vascular injury in Sprague-Dawley rats.

Sheth CM, Enerson BE, Peters D, Lawton MP, Weaver JL.

Toxicol Sci. 2011 Jul;122(1):7-15. doi: 10.1093/toxsci/kfr082. Epub 2011 Apr 16.

PMID:
21498876
5.

Potential candidate genomic biomarkers of drug induced vascular injury in the rat.

Dalmas DA, Scicchitano MS, Mullins D, Hughes-Earle A, Tatsuoka K, Magid-Slav M, Frazier KS, Thomas HC.

Toxicol Appl Pharmacol. 2011 Dec 1;257(2):284-300. doi: 10.1016/j.taap.2011.09.015. Epub 2011 Sep 24.

PMID:
21983523
6.

Mechanisms and biomarkers of cardiovascular injury induced by phosphodiesterase inhibitor III SK&F 95654 in the spontaneously hypertensive rat.

Zhang J, Herman EH, Robertson DG, Reily MD, Knapton A, Ratajczak HV, Rifai N, Honchel R, Blanchard KT, Stoll RE, Sistare FD.

Toxicol Pathol. 2006;34(2):152-63.

PMID:
16537294
7.

Characterization of the inflammatory response to a highly selective PDE4 inhibitor in the rat and the identification of biomarkers that correlate with toxicity.

Dietsch GN, Dipalma CR, Eyre RJ, Pham TQ, Poole KM, Pefaur NB, Welch WD, Trueblood E, Kerns WD, Kanaly ST.

Toxicol Pathol. 2006;34(1):39-51.

PMID:
16507543
8.

NTP Toxicology and Carcinogenesis Studies of Coumarin (CAS No. 91-64-5) in F344/N Rats and B6C3F1 Mice (Gavage Studies).

National Toxicology Program .

Natl Toxicol Program Tech Rep Ser. 1993 Sep;422:1-340.

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13.

The toxicity of SCH 351591, a novel phosphodiesterase-4 inhibitor, in Cynomolgus monkeys.

Losco PE, Evans EW, Barat SA, Blackshear PE, Reyderman L, Fine JS, Bober LA, Anthes JC, Mirro EJ, Cuss FM.

Toxicol Pathol. 2004 May-Jun;32(3):295-308.

PMID:
15204971
14.

Investigation of the molecular mechanisms preceding PDE4 inhibitor-induced vasculopathy in rats: tissue inhibitor of metalloproteinase 1, a potential predictive biomarker.

Daguès N, Pawlowski V, Sobry C, Hanton G, Borde F, Soler S, Freslon JL, Chevalier S.

Toxicol Sci. 2007 Nov;100(1):238-47. Epub 2007 Jun 14.

PMID:
17569694
16.

Myocardial and reproductive system toxicity of SCH 351591, a selective phosphodiesterase-4 inhibitor, in CD-1 mice.

Losco PE, Poulet FM, Kaminska-McNamara GZ, Klein MF.

Toxicol Pathol. 2010 Jun;38(4):568-82. doi: 10.1177/0192623310370463. Epub 2010 May 11.

PMID:
20460440
18.

Effect of dexamethasone on the metabonomics profile associated with phosphodiesterase inhibitor-induced vascular lesions in rats.

Slim RM, Robertson DG, Albassam M, Reily MD, Robosky L, Dethloff LA.

Toxicol Appl Pharmacol. 2002 Sep 1;183(2):108-9.

PMID:
12387750
19.

Altered gene expression in rat mesenteric tissue following in vivo exposure to a phosphodiesterase 4 inhibitor.

Daguès N, Pawlowski V, Guigon G, Ledieu D, Sobry C, Hanton G, Freslon JL, Chevalier S.

Toxicol Appl Pharmacol. 2007 Jan 1;218(1):52-63. Epub 2006 Oct 27.

PMID:
17157341
20.

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