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Items: 1 to 20 of 136

1.

Structural and functional insights into 5'-ppp RNA pattern recognition by the innate immune receptor RIG-I.

Wang Y, Ludwig J, Schuberth C, Goldeck M, Schlee M, Li H, Juranek S, Sheng G, Micura R, Tuschl T, Hartmann G, Patel DJ.

Nat Struct Mol Biol. 2010 Jul;17(7):781-7. doi: 10.1038/nsmb.1863. Epub 2010 Jun 27.

2.

Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5.

Li X, Lu C, Stewart M, Xu H, Strong RK, Igumenova T, Li P.

Arch Biochem Biophys. 2009 Aug 1;488(1):23-33. doi: 10.1016/j.abb.2009.06.008. Epub 2009 Jun 14.

PMID:
19531363
3.

Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors.

Takahasi K, Kumeta H, Tsuduki N, Narita R, Shigemoto T, Hirai R, Yoneyama M, Horiuchi M, Ogura K, Fujita T, Inagaki F.

J Biol Chem. 2009 Jun 26;284(26):17465-74. doi: 10.1074/jbc.M109.007179. Epub 2009 Apr 20.

4.

Structural basis of RNA recognition and activation by innate immune receptor RIG-I.

Jiang F, Ramanathan A, Miller MT, Tang GQ, Gale M Jr, Patel SS, Marcotrigiano J.

Nature. 2011 Sep 25;479(7373):423-7. doi: 10.1038/nature10537.

5.

Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate.

Lu C, Ranjith-Kumar CT, Hao L, Kao CC, Li P.

Nucleic Acids Res. 2011 Mar;39(4):1565-75. doi: 10.1093/nar/gkq974. Epub 2010 Oct 20.

6.

The structural basis of 5' triphosphate double-stranded RNA recognition by RIG-I C-terminal domain.

Lu C, Xu H, Ranjith-Kumar CT, Brooks MT, Hou TY, Hu F, Herr AB, Strong RK, Kao CC, Li P.

Structure. 2010 Aug 11;18(8):1032-43. doi: 10.1016/j.str.2010.05.007. Epub 2010 Jul 15.

7.

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA.

Pippig DA, Hellmuth JC, Cui S, Kirchhofer A, Lammens K, Lammens A, Schmidt A, Rothenfusser S, Hopfner KP.

Nucleic Acids Res. 2009 Apr;37(6):2014-25. doi: 10.1093/nar/gkp059. Epub 2009 Feb 10.

8.

The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA.

Li X, Ranjith-Kumar CT, Brooks MT, Dharmaiah S, Herr AB, Kao C, Li P.

J Biol Chem. 2009 May 15;284(20):13881-91. doi: 10.1074/jbc.M900818200. Epub 2009 Mar 11.

9.

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses.

Takahasi K, Yoneyama M, Nishihori T, Hirai R, Kumeta H, Narita R, Gale M Jr, Inagaki F, Fujita T.

Mol Cell. 2008 Feb 29;29(4):428-40. doi: 10.1016/j.molcel.2007.11.028. Epub 2008 Jan 31.

10.

Kinetic discrimination of self/non-self RNA by the ATPase activity of RIG-I and MDA5.

Louber J, Brunel J, Uchikawa E, Cusack S, Gerlier D.

BMC Biol. 2015 Jul 28;13:54. doi: 10.1186/s12915-015-0166-9.

11.

Structural insights into RNA recognition by RIG-I.

Luo D, Ding SC, Vela A, Kohlway A, Lindenbach BD, Pyle AM.

Cell. 2011 Oct 14;147(2):409-22. doi: 10.1016/j.cell.2011.09.023.

12.

A structure-based model of RIG-I activation.

Kolakofsky D, Kowalinski E, Cusack S.

RNA. 2012 Dec;18(12):2118-27. doi: 10.1261/rna.035949.112. Epub 2012 Nov 1. Review.

13.

RIG-I and dsRNA-induced IFNbeta activation.

Hausmann S, Marq JB, Tapparel C, Kolakofsky D, Garcin D.

PLoS One. 2008;3(12):e3965. doi: 10.1371/journal.pone.0003965. Epub 2008 Dec 30.

14.

Paramyxovirus V proteins disrupt the fold of the RNA sensor MDA5 to inhibit antiviral signaling.

Motz C, Schuhmann KM, Kirchhofer A, Moldt M, Witte G, Conzelmann KK, Hopfner KP.

Science. 2013 Feb 8;339(6120):690-3. doi: 10.1126/science.1230949. Epub 2013 Jan 17.

15.

Structure and function of LGP2, a DEX(D/H) helicase that regulates the innate immunity response.

Murali A, Li X, Ranjith-Kumar CT, Bhardwaj K, Holzenburg A, Li P, Kao CC.

J Biol Chem. 2008 Jun 6;283(23):15825-33. doi: 10.1074/jbc.M800542200. Epub 2008 Apr 14.

16.

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.

Cui S, Eisen├Ącher K, Kirchhofer A, Brz├│zka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP.

Mol Cell. 2008 Feb 1;29(2):169-79. doi: 10.1016/j.molcel.2007.10.032.

17.

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2.

Saito T, Hirai R, Loo YM, Owen D, Johnson CL, Sinha SC, Akira S, Fujita T, Gale M Jr.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):582-7. Epub 2006 Dec 26.

18.

Crystallization and preliminary crystallographic studies of human RIG-I in complex with double-stranded RNA.

Moon H, Choe J.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2009 Jun 1;65(Pt 6):648-50. doi: 10.1107/S1744309109018405. Epub 2009 May 23.

19.

Structural basis for dsRNA recognition, filament formation, and antiviral signal activation by MDA5.

Wu B, Peisley A, Richards C, Yao H, Zeng X, Lin C, Chu F, Walz T, Hur S.

Cell. 2013 Jan 17;152(1-2):276-89. doi: 10.1016/j.cell.2012.11.048. Epub 2012 Dec 27.

20.

RIG-I ATPase activity and discrimination of self-RNA versus non-self-RNA.

Anchisi S, Guerra J, Garcin D.

MBio. 2015 Mar 3;6(2):e02349. doi: 10.1128/mBio.02349-14.

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