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Items: 1 to 20 of 122

1.

Pharmacokinetics of 2 dapivirine vaginal microbicide gels and their safety vs. Hydroxyethyl cellulose-based universal placebo gel.

Nel AM, Smythe SC, Habibi S, Kaptur PE, Romano JW.

J Acquir Immune Defic Syndr. 2010 Oct;55(2):161-9. doi: 10.1097/QAI.0b013e3181e3293a.

PMID:
20574411
2.

Safety, tolerability, and systemic absorption of dapivirine vaginal microbicide gel in healthy, HIV-negative women.

Nel AM, Coplan P, van de Wijgert JH, Kapiga SH, von Mollendorf C, Geubbels E, Vyankandondera J, Rees HV, Masenga G, Kiwelu I, Moyes J, Smythe SC.

AIDS. 2009 Jul 31;23(12):1531-8. doi: 10.1097/QAD.0b013e32832c413d.

PMID:
19550287
3.

Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative women.

Nel A, Smythe S, Young K, Malcolm K, McCoy C, Rosenberg Z, Romano J.

J Acquir Immune Defic Syndr. 2009 Aug 1;51(4):416-23.

PMID:
19623693
4.

A Phase 1 Trial to Assess the Safety, Acceptability, Pharmacokinetics, and Pharmacodynamics of a Novel Dapivirine Vaginal Film.

Bunge KE, Dezzutti CS, Rohan LC, Hendrix CW, Marzinke MA, Richardson-Harman N, Moncla BJ, Devlin B, Meyn LA, Spiegel HM, Hillier SL.

J Acquir Immune Defic Syndr. 2016 Apr 15;71(5):498-505. doi: 10.1097/QAI.0000000000000897.

5.

Dose-ranging phase 1 study of TMC120, a promising vaginal microbicide, in HIV-negative and HIV-positive female volunteers.

Jespers VA, Van Roey JM, Beets GI, Buvé AM.

J Acquir Immune Defic Syndr. 2007 Feb 1;44(2):154-8.

PMID:
17106275
6.

A safety and pharmacokinetic trial assessing delivery of dapivirine from a vaginal ring in healthy women.

Nel A, Haazen W, Nuttall J, Romano J, Rosenberg Z, van Niekerk N.

AIDS. 2014 Jun 19;28(10):1479-87. doi: 10.1097/QAD.0000000000000280.

PMID:
24901365
7.

Concentrations of dapivirine in the rhesus macaque and rabbit following once daily intravaginal administration of a gel formulation of [14C]dapivirine for 7 days.

Nuttall JP, Thake DC, Lewis MG, Ferkany JW, Romano JW, Mitchnick MA.

Antimicrob Agents Chemother. 2008 Mar;52(3):909-14. Epub 2007 Dec 17.

8.

Pharmacokinetic assessment of dapivirine vaginal microbicide gel in healthy, HIV-negative women.

Nel AM, Coplan P, Smythe SC, McCord K, Mitchnick M, Kaptur PE, Romano J.

AIDS Res Hum Retroviruses. 2010 Nov;26(11):1181-90. doi: 10.1089/aid.2009.0227. Epub 2010 Sep 21.

PMID:
20854207
9.

Safety and acceptability of cellulose sulfate as a vaginal microbicide in HIV-infected women.

El-Sadr WM, Mayer KH, Maslankowski L, Hoesley C, Justman J, Gai F, Mauck C, Absalon J, Morrow K, Mâsse B, Soto-Torres L, Kwiecien A.

AIDS. 2006 May 12;20(8):1109-16.

PMID:
16691061
10.

Safety, tolerability, and pharmacokinetics of SPL7013 gel (VivaGel): a dose ranging, phase I study.

O'Loughlin J, Millwood IY, McDonald HM, Price CF, Kaldor JM, Paull JR.

Sex Transm Dis. 2010 Feb;37(2):100-4. doi: 10.1097/OLQ.0b013e3181bc0aac.

PMID:
19823111
11.

The sheep as a model of preclinical safety and pharmacokinetic evaluations of candidate microbicides.

Holt JD, Cameron D, Dias N, Holding J, Muntendam A, Oostebring F, Dreier P, Rohan L, Nuttall J.

Antimicrob Agents Chemother. 2015 Jul;59(7):3761-70. doi: 10.1128/AAC.04954-14. Epub 2015 Apr 6.

12.

Safety, Acceptability and Adherence of Dapivirine Vaginal Ring in a Microbicide Clinical Trial Conducted in Multiple Countries in Sub-Saharan Africa.

Nel A, Bekker LG, Bukusi E, Hellstrӧm E, Kotze P, Louw C, Martinson F, Masenga G, Montgomery E, Ndaba N, van der Straten A, van Niekerk N, Woodsong C.

PLoS One. 2016 Mar 10;11(3):e0147743. doi: 10.1371/journal.pone.0147743. eCollection 2016.

13.

Pharmacokinetic modeling of a gel-delivered dapivirine microbicide in humans.

Halwes ME, Steinbach-Rankins JM, Frieboes HB.

Eur J Pharm Sci. 2016 Oct 10;93:410-8. doi: 10.1016/j.ejps.2016.08.037. Epub 2016 Aug 21.

PMID:
27559026
14.

Safety and availability of dapivirine (TMC120) delivered from an intravaginal ring.

Romano J, Variano B, Coplan P, Van Roey J, Douville K, Rosenberg Z, Temmerman M, Verstraelen H, Van Bortel L, Weyers S, Mitchnick M.

AIDS Res Hum Retroviruses. 2009 May;25(5):483-8. doi: 10.1089/aid.2008.0184.

PMID:
19388819
15.

Safety and tolerability of tenofovir vaginal gel in abstinent and sexually active HIV-infected and uninfected women.

Mayer KH, Maslankowski LA, Gai F, El-Sadr WM, Justman J, Kwiecien A, Mâsse B, Eshleman SH, Hendrix C, Morrow K, Rooney JF, Soto-Torres L; HPTN 050 Protocol Team..

AIDS. 2006 Feb 28;20(4):543-51.

PMID:
16470118
16.

A randomized male tolerance study of dapivirine gel following multiple topical penile exposures (MTN 012/IPM 010).

Cranston RD, Hoesley C, Carballo-Diéguez A, Hendrix CW, Husnik M, Levy L, Hall W, Soto-Torres L, Nel AM.

AIDS Res Hum Retroviruses. 2014 Feb;30(2):184-9. doi: 10.1089/AID.2013.0170. Epub 2013 Oct 26.

17.

Single-dose escalation and multiple-dose safety, tolerability, and pharmacokinetics of IDX899, a candidate human immunodeficiency virus type 1 nonnucleoside reverse transcriptase inhibitor, in healthy subjects.

Zhou XJ, Pietropaolo K, Damphousse D, Belanger B, Chen J, Sullivan-Bólyai J, Mayers D.

Antimicrob Agents Chemother. 2009 May;53(5):1739-46. doi: 10.1128/AAC.01479-08. Epub 2009 Feb 17.

18.

Pre-clinical development of a combination microbicide vaginal ring containing dapivirine and darunavir.

Murphy DJ, Desjardins D, Dereuddre-Bosquet N, Brochard P, Perrot L, Pruvost A, Le Grand R, Lagatie O, Vanhooren L, Feyaerts M, van Roey J, Malcolm RK.

J Antimicrob Chemother. 2014 Sep;69(9):2477-88. doi: 10.1093/jac/dku160. Epub 2014 May 26.

PMID:
24862093
19.

A randomized, double-blind, placebo-controlled safety and acceptability study of two Invisible Condom formulations in women from Cameroon.

Mbopi-Keou FX, Trottier S, Omar RF, Nkele NN, Fokoua S, Mbu ER, Giguere JF, Domingo MC, Piret J, Tsague L, Zekeng L, Mwatha A, Mâsse B, Bergeron MG.

Contraception. 2009 Nov;80(5):484-92. doi: 10.1016/j.contraception.2009.03.020. Epub 2009 May 23.

PMID:
19835725
20.

Fourteen-day safety and acceptability study of the universal placebo gel.

Schwartz JL, Ballagh SA, Kwok C, Mauck CK, Weiner DH, Rencher WF, Callahan MM.

Contraception. 2007 Feb;75(2):136-41. Epub 2006 Oct 25.

PMID:
17241844

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