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Items: 1 to 20 of 133

1.

Role of presenilins in neuronal calcium homeostasis.

Zhang H, Sun S, Herreman A, De Strooper B, Bezprozvanny I.

J Neurosci. 2010 Jun 23;30(25):8566-80. doi: 10.1523/JNEUROSCI.1554-10.2010.

2.

Presenilins as endoplasmic reticulum calcium leak channels and Alzheimer's disease pathogenesis.

Supnet C, Bezprozvanny I.

Sci China Life Sci. 2011 Aug;54(8):744-51. doi: 10.1007/s11427-011-4201-y. Epub 2011 Jul 24. Review.

PMID:
21786197
3.

Familial Alzheimer's disease mutations in presenilins: effects on endoplasmic reticulum calcium homeostasis and correlation with clinical phenotypes.

Nelson O, Supnet C, Liu H, Bezprozvanny I.

J Alzheimers Dis. 2010;21(3):781-93. doi: 10.3233/JAD-2010-100159.

4.

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations.

Tu H, Nelson O, Bezprozvanny A, Wang Z, Lee SF, Hao YH, Serneels L, De Strooper B, Yu G, Bezprozvanny I.

Cell. 2006 Sep 8;126(5):981-93.

5.

Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.

Oulès B, Del Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, Moreno S, Paterlini-Bréchot P, Trebak M, Checler F, Benfenati F, Chami M.

J Neurosci. 2012 Aug 22;32(34):11820-34.

6.

Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease.

Chakroborty S, Briggs C, Miller MB, Goussakov I, Schneider C, Kim J, Wicks J, Richardson JC, Conklin V, Cameransi BG, Stutzmann GE.

PLoS One. 2012;7(12):e52056. doi: 10.1371/journal.pone.0052056. Epub 2012 Dec 21.

7.

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.

Nelson O, Tu H, Lei T, Bentahir M, de Strooper B, Bezprozvanny I.

J Clin Invest. 2007 May;117(5):1230-9. Epub 2007 Apr 12.

8.

Presenilins function in ER calcium leak and Alzheimer's disease pathogenesis.

Supnet C, Bezprozvanny I.

Cell Calcium. 2011 Sep;50(3):303-9. doi: 10.1016/j.ceca.2011.05.013. Epub 2011 Jun 12. Review.

9.

Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels.

Shilling D, Mak DO, Kang DE, Foskett JK.

J Biol Chem. 2012 Mar 30;287(14):10933-44. doi: 10.1074/jbc.M111.300491. Epub 2012 Feb 6.

10.

Repression of transcription of presenilin-1 inhibits γ-secretase independent ER Ca²⁺ leak that is impaired by FAD mutations.

Das HK, Tchedre K, Mueller B.

J Neurochem. 2012 Aug;122(3):487-500. doi: 10.1111/j.1471-4159.2012.07794.x. Epub 2012 Jun 22.

11.

The role of ryanodine receptor type 3 in a mouse model of Alzheimer disease.

Liu J, Supnet C, Sun S, Zhang H, Good L, Popugaeva E, Bezprozvanny I.

Channels (Austin). 2014;8(3):230-42.

12.

Presenilins and calcium signaling-systems biology to the rescue.

Bezprozvanny I.

Sci Signal. 2013 Jul 9;6(283):pe24. doi: 10.1126/scisignal.2004296. Review.

13.

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

Wu B, Yamaguchi H, Lai FA, Shen J.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15091-6. doi: 10.1073/pnas.1304171110. Epub 2013 Aug 5.

14.

Dysregulation of neuronal calcium homeostasis in Alzheimer's disease - A therapeutic opportunity?

Popugaeva E, Pchitskaya E, Bezprozvanny I.

Biochem Biophys Res Commun. 2017 Feb 19;483(4):998-1004. doi: 10.1016/j.bbrc.2016.09.053. Epub 2016 Sep 15. Review.

PMID:
27641664
15.

Presenilins are essential for regulating neurotransmitter release.

Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J.

Nature. 2009 Jul 30;460(7255):632-6. doi: 10.1038/nature08177.

16.

Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels.

Zatti G, Burgo A, Giacomello M, Barbiero L, Ghidoni R, Sinigaglia G, Florean C, Bagnoli S, Binetti G, Sorbi S, Pizzo P, Fasolato C.

Cell Calcium. 2006 Jun;39(6):539-50. Epub 2006 Apr 18.

PMID:
16620965
17.

Neuronal calcium signaling and Alzheimer's disease.

Woods NK, Padmanabhan J.

Adv Exp Med Biol. 2012;740:1193-217. doi: 10.1007/978-94-007-2888-2_54. Review.

PMID:
22453989
18.

Ca(2+) -dependent endoplasmic reticulum stress correlates with astrogliosis in oligomeric amyloid β-treated astrocytes and in a model of Alzheimer's disease.

Alberdi E, Wyssenbach A, Alberdi M, Sánchez-Gómez MV, Cavaliere F, Rodríguez JJ, Verkhratsky A, Matute C.

Aging Cell. 2013 Apr;12(2):292-302. doi: 10.1111/acel.12054. Epub 2013 Feb 28.

19.

Presenilin transgenic mice as models of Alzheimer's disease.

Elder GA, Gama Sosa MA, De Gasperi R, Dickstein DL, Hof PR.

Brain Struct Funct. 2010 Mar;214(2-3):127-43. doi: 10.1007/s00429-009-0227-3. Epub 2009 Nov 18. Review.

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