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Items: 1 to 20 of 104

1.

Activation of the farnesoid X receptor provides protection against acetaminophen-induced hepatic toxicity.

Lee FY, de Aguiar Vallim TQ, Chong HK, Zhang Y, Liu Y, Jones SA, Osborne TF, Edwards PA.

Mol Endocrinol. 2010 Aug;24(8):1626-36. doi: 10.1210/me.2010-0117. Epub 2010 Jun 23.

2.

Farnesoid X receptor induces murine scavenger receptor Class B type I via intron binding.

Li G, Thomas AM, Williams JA, Kong B, Liu J, Inaba Y, Xie W, Guo GL.

PLoS One. 2012;7(4):e35895. doi: 10.1371/journal.pone.0035895. Epub 2012 Apr 23.

3.

Hematopoietically expressed homeobox is a target gene of farnesoid X receptor in chenodeoxycholic acid-induced liver hypertrophy.

Xing X, Burgermeister E, Geisler F, Einwächter H, Fan L, Hiber M, Rauser S, Walch A, Röcken C, Ebeling M, Wright MB, Schmid RM, Ebert MP.

Hepatology. 2009 Mar;49(3):979-88. doi: 10.1002/hep.22712.

PMID:
19072826
4.

Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice.

Lee J, Seok S, Yu P, Kim K, Smith Z, Rivas-Astroza M, Zhong S, Kemper JK.

Hepatology. 2012 Jul;56(1):108-17. doi: 10.1002/hep.25609. Epub 2012 Apr 24.

5.

Farnesoid X Receptor Activation Promotes Hepatic Amino Acid Catabolism and Ammonium Clearance in Mice.

Massafra V, Milona A, Vos HR, Ramos RJJ, Gerrits J, Willemsen ECL, Ramos Pittol JM, Ijssennagger N, Houweling M, Prinsen HCMT, Verhoeven-Duif NM, Burgering BMT, van Mil SWC.

Gastroenterology. 2017 May;152(6):1462-1476.e10. doi: 10.1053/j.gastro.2017.01.014. Epub 2017 Jan 25.

6.

Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding.

Kay HY, Kim WD, Hwang SJ, Choi HS, Gilroy RK, Wan YJ, Kim SG.

Antioxid Redox Signal. 2011 Oct 15;15(8):2135-46. doi: 10.1089/ars.2010.3834. Epub 2011 Jun 13.

PMID:
21504366
7.

Farnesoid X receptor directly regulates xenobiotic detoxification genes in the long-lived Little mice.

Jiang Y, Jin J, Iakova P, Hernandez JC, Jawanmardi N, Sullivan E, Guo GL, Timchenko NA, Darlington GJ.

Mech Ageing Dev. 2013 Sep;134(9):407-15. doi: 10.1016/j.mad.2013.08.003. Epub 2013 Sep 2.

8.

Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor.

Pineda Torra I, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B.

Mol Endocrinol. 2003 Feb;17(2):259-72.

PMID:
12554753
9.

Peroxisome proliferator-activated receptor alpha-null mice lack resistance to acetaminophen hepatotoxicity following clofibrate exposure.

Chen C, Hennig GE, Whiteley HE, Corton JC, Manautou JE.

Toxicol Sci. 2000 Oct;57(2):338-44.

PMID:
11006363
10.

Activation of the nuclear receptor FXR enhances hepatocyte chemoprotection and liver tumor chemoresistance against genotoxic compounds.

Vaquero J, Briz O, Herraez E, Muntané J, Marin JJ.

Biochim Biophys Acta. 2013 Oct;1833(10):2212-9. doi: 10.1016/j.bbamcr.2013.05.006. Epub 2013 May 13.

11.

The hepatic orosomucoid/α1-acid glycoprotein gene cluster is regulated by the nuclear bile acid receptor FXR.

Porez G, Gross B, Prawitt J, Gheeraert C, Berrabah W, Alexandre J, Staels B, Lefebvre P.

Endocrinology. 2013 Oct;154(10):3690-701. doi: 10.1210/en.2013-1263. Epub 2013 Jul 16.

PMID:
23861371
12.

Farnesoid X receptor inhibits the transcriptional activity of carbohydrate response element binding protein in human hepatocytes.

Caron S, Huaman Samanez C, Dehondt H, Ploton M, Briand O, Lien F, Dorchies E, Dumont J, Postic C, Cariou B, Lefebvre P, Staels B.

Mol Cell Biol. 2013 Jun;33(11):2202-11. doi: 10.1128/MCB.01004-12. Epub 2013 Mar 25.

13.

Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol.

Chow EC, Magomedova L, Quach HP, Patel R, Durk MR, Fan J, Maeng HJ, Irondi K, Anakk S, Moore DD, Cummins CL, Pang KS.

Gastroenterology. 2014 Apr;146(4):1048-59. doi: 10.1053/j.gastro.2013.12.027. Epub 2013 Dec 21.

PMID:
24365583
14.

Bile-acid-activated farnesoid X receptor regulates hydrogen sulfide production and hepatic microcirculation.

Renga B, Mencarelli A, Migliorati M, Distrutti E, Fiorucci S.

World J Gastroenterol. 2009 May 7;15(17):2097-108.

15.

Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition.

Renga B, Mencarelli A, D'Amore C, Cipriani S, Baldelli F, Zampella A, Distrutti E, Fiorucci S.

FASEB J. 2012 Jul;26(7):3021-31. doi: 10.1096/fj.11-195701. Epub 2012 Mar 23.

PMID:
22447981
16.

Poly(ADP-ribose) polymerase 1 promotes oxidative-stress-induced liver cell death via suppressing farnesoid X receptor α.

Wang C, Zhang F, Wang L, Zhang Y, Li X, Huang K, Du M, Liu F, Huang S, Guan Y, Huang D, Huang K.

Mol Cell Biol. 2013 Nov;33(22):4492-503. doi: 10.1128/MCB.00160-13. Epub 2013 Sep 16.

17.

The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate.

Renga B, Mencarelli A, Cipriani S, D'Amore C, Zampella A, Monti MC, Distrutti E, Fiorucci S.

Biochim Biophys Acta. 2011 Nov;1812(11):1522-31. doi: 10.1016/j.bbadis.2011.06.009. Epub 2011 Jul 1.

18.

Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity.

Jin J, Sun X, Zhao Z, Wang W, Qiu Y, Fu X, Huang M, Huang Z.

Phytomedicine. 2015 Sep 15;22(10):894-901. doi: 10.1016/j.phymed.2015.06.007. Epub 2015 Jul 3.

PMID:
26321738
19.

Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression.

Claudel T, Inoue Y, Barbier O, Duran-Sandoval D, Kosykh V, Fruchart J, Fruchart JC, Gonzalez FJ, Staels B.

Gastroenterology. 2003 Aug;125(2):544-55.

PMID:
12891557
20.

The nuclear receptor FXR uncouples the actions of miR-33 from SREBP-2.

Tarling EJ, Ahn H, de Aguiar Vallim TQ.

Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):787-95. doi: 10.1161/ATVBAHA.114.304179. Epub 2015 Jan 15.

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