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Items: 1 to 20 of 151

1.

Synthesis and structure-affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes.

Cummings DF, Canseco DC, Sheth P, Johnson JE, Schetz JA.

Bioorg Med Chem. 2010 Jul 1;18(13):4783-92. doi: 10.1016/j.bmc.2010.05.017. Epub 2010 May 15.

2.

New 5-HT1A, 5HT2A and 5HT2C receptor ligands containing a picolinic nucleus: Synthesis, in vitro and in vivo pharmacological evaluation.

Fiorino F, Magli E, Kędzierska E, Ciano A, Corvino A, Severino B, Perissutti E, Frecentese F, Di Vaio P, Saccone I, Izzo AA, Capasso R, Massarelli P, Rossi I, Orzelska-Gòrka J, Kotlińska JH, Santagada V, Caliendo G.

Bioorg Med Chem. 2017 Oct 15;25(20):5820-5837. doi: 10.1016/j.bmc.2017.09.018. Epub 2017 Sep 18.

PMID:
28943244
3.

Synthesis and in vitro pharmacological evaluation of a new series of 5-HT1A 5-HT2A and 5-HT2C receptor ligands containing a norbornene nucleus.

Fiorino F, Severino B, De Angelis F, Perissutti E, Magli E, Frecentese F, Esposito A, Massarelli P, Nencini C, Viti B, Santagada V, Caliendo G.

Pharmazie. 2009 Sep;64(9):555-64.

PMID:
19827295
4.

Synthesis and serotonin receptor affinities of a series of trans-2-(indol-3-yl)cyclopropylamine derivatives.

Vangveravong S, Kanthasamy A, Lucaites VL, Nelson DL, Nichols DE.

J Med Chem. 1998 Dec 3;41(25):4995-5001.

PMID:
9836617
5.

A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists.

Goodacre CJ, Bromidge SM, Clapham D, King FD, Lovell PJ, Allen M, Campbell LP, Holland V, Riley GJ, Starr KR, Trail BK, Wood MD.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):4989-93.

PMID:
16168649
6.

In vitro structure-activity relationships of aplysinopsin analogs and their in vivo evaluation in the chick anxiety-depression model.

Lewellyn K, Bialonska D, Loria MJ, White SW, Sufka KJ, Zjawiony JK.

Bioorg Med Chem. 2013 Nov 15;21(22):7083-90. doi: 10.1016/j.bmc.2013.09.011. Epub 2013 Sep 15.

PMID:
24084296
7.

Synthesis and biological evaluation of novel pyrrolidine-2,5-dione derivatives as potential antidepressant agents. Part 1.

Wróbel MZ, Chodkowski A, Herold F, Gomółka A, Kleps J, Mazurek AP, Pluciński F, Mazurek A, Nowak G, Siwek A, Stachowicz K, Sławińska A, Wolak M, Szewczyk B, Satała G, Bojarski AJ, Turło J.

Eur J Med Chem. 2013 May;63:484-500. doi: 10.1016/j.ejmech.2013.02.033. Epub 2013 Mar 5.

PMID:
23524160
8.

Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists.

Hansen M, Phonekeo K, Paine JS, Leth-Petersen S, Begtrup M, Bräuner-Osborne H, Kristensen JL.

ACS Chem Neurosci. 2014 Mar 19;5(3):243-9. doi: 10.1021/cn400216u. Epub 2014 Jan 15.

9.

Development of homogeneous high-affinity agonist binding assays for 5-HT2 receptor subtypes.

Song J, Hanniford D, Doucette C, Graham E, Poole MF, Ting A, Sherf B, Harrington J, Brunden K, Stricker-Krongrad A.

Assay Drug Dev Technol. 2005 Dec;3(6):649-59.

PMID:
16438660
10.

Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands.

Chang-Fong J, Tyacke RJ, Lau A, Westaway J, Hudson AL, Glennon RA.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.

PMID:
15013010
11.
13.

Novel spirohydantoin derivative as a potent multireceptor-active antipsychotic and antidepressant agent.

Czopek A, Kołaczkowski M, Bucki A, Byrtus H, Pawłowski M, Kazek G, Bojarski AJ, Piaskowska A, Kalinowska-Tłuścik J, Partyka A, Wesołowska A.

Bioorg Med Chem. 2015 Jul 1;23(13):3436-47. doi: 10.1016/j.bmc.2015.04.026. Epub 2015 Apr 16.

PMID:
25936259
14.

Postnatal fluoxetine-evoked anxiety is prevented by concomitant 5-HT2A/C receptor blockade and mimicked by postnatal 5-HT2A/C receptor stimulation.

Sarkar A, Chachra P, Vaidya VA.

Biol Psychiatry. 2014 Dec 1;76(11):858-68. doi: 10.1016/j.biopsych.2013.11.005. Epub 2013 Nov 11.

PMID:
24315410
15.

Synthesis and 5-HT1A/5-HT2A receptor activity of new N-[3-(4-phenylpiperazin-1-yl)-propyl] derivatives of 3-spiro-cyclohexanepyrrolidine-2,5-dione and 3-spiro-beta-tetralonepyrrolidine-2,5-dione.

Obniska J, Pawłowski M, Kołaczkowski M, Czopek A, Duszyńska B, Klodzińska A, Tatarczyńska E, Chojnacka-Wójcik E.

Pol J Pharmacol. 2003 Jul-Aug;55(4):553-7.

16.

Effects of the serotonin 5-HT2A and 5-HT2C receptor ligands on the discriminative stimulus effects of nicotine in rats.

Zaniewska M, McCreary AC, Przegaliński E, Filip M.

Eur J Pharmacol. 2007 Oct 1;571(2-3):156-65. Epub 2007 Jun 13.

PMID:
17617403
17.

New 5-hydroxytryptamine(1A) receptor ligands containing a norbornene nucleus: synthesis and in vitro pharmacological evaluation.

Fiorino F, Perissutti E, Severino B, Santagada V, Cirillo D, Terracciano S, Massarelli P, Bruni G, Collavoli E, Renner C, Caliendo G.

J Med Chem. 2005 Aug 25;48(17):5495-503.

PMID:
16107148
18.

Novel 4-alkyl-1-arylpiperazines and 1,2,3,4-tetrahydroisoquinolines containing diphenylmethylamino or diphenylmethoxy fragment with differentiated 5-HT1A/5-HT2A/D2 receptor activity.

Paluchowska MH, Mokrosz MJ, Charakchieva-Minol S, Duszyńska B, Kozioł A, Wesołowska A, Stachowicz K, Chojnacka-Wójcik E.

Pol J Pharmacol. 2003 Jul-Aug;55(4):543-52.

19.

Structure-5-HT receptor affinity relationship in a new group of 7-arylpiperazynylalkyl and 7-tetrahydroisoquinolinylalkyl derivatives of 8-amino-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione.

Żmudzki P, Chłoń-Rzepa G, Bojarski AJ, Zygmunt M, Kazek G, Mordyl B, Pawłowski M.

Arch Pharm (Weinheim). 2015 Apr;348(4):229-41. doi: 10.1002/ardp.201400392. Epub 2015 Mar 13.

PMID:
25773578
20.

Multiple conformations of 5-HT2A and 5-HT 2C receptors in rat brain: an autoradiographic study with [125I](±)DOI.

López-Giménez JF, Vilaró MT, Palacios JM, Mengod G.

Exp Brain Res. 2013 Oct;230(4):395-406. doi: 10.1007/s00221-013-3636-8. Epub 2013 Jul 18.

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