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Items: 1 to 20 of 233

1.

Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture.

Savile CK, Janey JM, Mundorff EC, Moore JC, Tam S, Jarvis WR, Colbeck JC, Krebber A, Fleitz FJ, Brands J, Devine PN, Huisman GW, Hughes GJ.

Science. 2010 Jul 16;329(5989):305-9. doi: 10.1126/science.1188934. Epub 2010 Jun 17.

2.

Recent achievements in developing the biocatalytic toolbox for chiral amine synthesis.

Kohls H, Steffen-Munsberg F, Höhne M.

Curr Opin Chem Biol. 2014 Apr;19:180-92. doi: 10.1016/j.cbpa.2014.02.021. Epub 2014 Apr 12. Review.

PMID:
24721252
3.

Biochemistry. Reengineering enzymes.

Lutz S.

Science. 2010 Jul 16;329(5989):285-7. doi: 10.1126/science.1192224. No abstract available.

4.

Enzymatic racemization of amines catalyzed by enantiocomplementary ω-transaminases.

Koszelewski D, Grischek B, Glueck SM, Kroutil W, Faber K.

Chemistry. 2011 Jan 3;17(1):378-83. doi: 10.1002/chem.201001602. Epub 2010 Nov 30.

PMID:
21207634
5.

Inventing and understanding catalytic, enantioselective reactions.

Shibasaki M, Kumagai N, Mashiko T.

Curr Opin Drug Discov Devel. 2009 Nov;12(6):862-75. Review.

PMID:
19894195
6.

Development of an amine dehydrogenase for synthesis of chiral amines.

Abrahamson MJ, Vázquez-Figueroa E, Woodall NB, Moore JC, Bommarius AS.

Angew Chem Int Ed Engl. 2012 Apr 16;51(16):3969-72. doi: 10.1002/anie.201107813. Epub 2012 Mar 6.

PMID:
22396126
7.

Features and technical applications of ω-transaminases.

Malik MS, Park ES, Shin JS.

Appl Microbiol Biotechnol. 2012 Jun;94(5):1163-71. doi: 10.1007/s00253-012-4103-3. Epub 2012 May 4. Review.

PMID:
22555915
8.

Biocatalytic strategies for the asymmetric synthesis of alpha-hydroxy ketones.

Hoyos P, Sinisterra JV, Molinari F, Alcántara AR, Domínguez de María P.

Acc Chem Res. 2010 Feb 16;43(2):288-99. doi: 10.1021/ar900196n.

PMID:
19908854
9.

Sitagliptin manufacture: a compelling tale of green chemistry, process intensification, and industrial asymmetric catalysis.

Desai AA.

Angew Chem Int Ed Engl. 2011 Feb 25;50(9):1974-6. doi: 10.1002/anie.201007051. Epub 2011 Jan 31. No abstract available.

PMID:
21284073
10.

Highly efficient asymmetric synthesis of sitagliptin.

Hansen KB, Hsiao Y, Xu F, Rivera N, Clausen A, Kubryk M, Krska S, Rosner T, Simmons B, Balsells J, Ikemoto N, Sun Y, Spindler F, Malan C, Grabowski EJ, Armstrong JD 3rd.

J Am Chem Soc. 2009 Jul 1;131(25):8798-804. doi: 10.1021/ja902462q.

PMID:
19507853
11.

Biocatalytic routes to chiral amines and amino acids.

Gotor-Fernández V, Gotor V.

Curr Opin Drug Discov Devel. 2009 Nov;12(6):784-97. Review.

PMID:
19894190
12.

Process considerations for the asymmetric synthesis of chiral amines using transaminases.

Tufvesson P, Lima-Ramos J, Jensen JS, Al-Haque N, Neto W, Woodley JM.

Biotechnol Bioeng. 2011 Jul;108(7):1479-93. doi: 10.1002/bit.23154. Epub 2011 Apr 14. Review.

PMID:
21455931
13.

omega-Transaminases for the synthesis of non-racemic alpha-chiral primary amines.

Koszelewski D, Tauber K, Faber K, Kroutil W.

Trends Biotechnol. 2010 Jun;28(6):324-32. doi: 10.1016/j.tibtech.2010.03.003. Epub 2010 Apr 27. Review.

PMID:
20430457
14.

Omega-transaminases as efficient biocatalysts to obtain novel chiral selenium-amine ligands for Pd-catalysis.

Andrade LH, Silva AV, Milani P, Koszelewski D, Kroutil W.

Org Biomol Chem. 2010 May 7;8(9):2043-51. doi: 10.1039/b920946h. Epub 2010 Mar 3.

PMID:
20401380
15.

Redesigning the substrate specificity of omega-aminotransferase for the kinetic resolution of aliphatic chiral amines.

Cho BK, Park HY, Seo JH, Kim J, Kang TJ, Lee BS, Kim BG.

Biotechnol Bioeng. 2008 Feb 1;99(2):275-84.

PMID:
17680656
16.

Two subtle amino Acid changes in a transaminase substantially enhance or invert enantiopreference in cascade syntheses.

Skalden L, Peters C, Dickerhoff J, Nobili A, Joosten HJ, Weisz K, Höhne M, Bornscheuer UT.

Chembiochem. 2015 May 4;16(7):1041-5. doi: 10.1002/cbic.201500074. Epub 2015 Mar 20.

PMID:
25801772
17.

Engineered enzymes for improved organic synthesis.

Hult K, Berglund P.

Curr Opin Biotechnol. 2003 Aug;14(4):395-400. Review.

PMID:
12943848
18.

Biocatalytic ketone reduction: a green and efficient access to enantiopure alcohols.

Ni Y, Xu JH.

Biotechnol Adv. 2012 Nov-Dec;30(6):1279-88. doi: 10.1016/j.biotechadv.2011.10.007. Epub 2011 Oct 30. Review.

PMID:
22079798
19.

Induced axial chirality in biocatalytic asymmetric ketone reduction.

Agudo R, Roiban GD, Reetz MT.

J Am Chem Soc. 2013 Feb 6;135(5):1665-8. doi: 10.1021/ja3092517. Epub 2012 Nov 7.

PMID:
23075382
20.

Design of chiral bifunctional secondary amine catalysts for asymmetric enamine catalysis.

Kano T, Maruoka K.

Chem Commun (Camb). 2008 Nov 21;(43):5465-73. doi: 10.1039/b809301f. Epub 2008 Sep 10.

PMID:
18997926

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