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A septin diffusion barrier at the base of the primary cilium maintains ciliary membrane protein distribution.

Hu Q, Milenkovic L, Jin H, Scott MP, Nachury MV, Spiliotis ET, Nelson WJ.

Science. 2010 Jul 23;329(5990):436-9. doi: 10.1126/science.1191054. Epub 2010 Jun 17.


Ciliary diffusion barrier: the gatekeeper for the primary cilium compartment.

Hu Q, Nelson WJ.

Cytoskeleton (Hoboken). 2011 Jun;68(6):313-24. doi: 10.1002/cm.20514. Epub 2011 Jun 10. Review.


Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length.

Ghossoub R, Hu Q, Failler M, Rouyez MC, Spitzbarth B, Mostowy S, Wolfrum U, Saunier S, Cossart P, Jamesnelson W, Benmerah A.

J Cell Sci. 2013 Jun 15;126(Pt 12):2583-94. doi: 10.1242/jcs.111377. Epub 2013 Apr 9.


The role of ciliary trafficking in Hedgehog receptor signaling.

Kim J, Hsia EY, Brigui A, Plessis A, Beachy PA, Zheng X.

Sci Signal. 2015 Jun 2;8(379):ra55. doi: 10.1126/scisignal.aaa5622.


Patched1 regulates hedgehog signaling at the primary cilium.

Rohatgi R, Milenkovic L, Scott MP.

Science. 2007 Jul 20;317(5836):372-6.


Supernumerary centrosomes nucleate extra cilia and compromise primary cilium signaling.

Mahjoub MR, Stearns T.

Curr Biol. 2012 Sep 11;22(17):1628-34. doi: 10.1016/j.cub.2012.06.057. Epub 2012 Jul 26.


Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins.

Larkins CE, Aviles GD, East MP, Kahn RA, Caspary T.

Mol Biol Cell. 2011 Dec;22(23):4694-703. doi: 10.1091/mbc.E10-12-0994. Epub 2011 Oct 5.


Primary cilia are specialized calcium signalling organelles.

Delling M, DeCaen PG, Doerner JF, Febvay S, Clapham DE.

Nature. 2013 Dec 12;504(7479):311-4. doi: 10.1038/nature12833.


A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain.

Chih B, Liu P, Chinn Y, Chalouni C, Komuves LG, Hass PE, Sandoval W, Peterson AS.

Nat Cell Biol. 2011 Dec 18;14(1):61-72. doi: 10.1038/ncb2410.


Cell biology. Septins at the nexus.

Barral Y.

Science. 2010 Sep 10;329(5997):1289-90. doi: 10.1126/science.1195445. No abstract available.


The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization.

Reiter JF, Blacque OE, Leroux MR.

EMBO Rep. 2012 Jun 29;13(7):608-18. doi: 10.1038/embor.2012.73. Review.


The graded response to Sonic Hedgehog depends on cilia architecture.

Caspary T, Larkins CE, Anderson KV.

Dev Cell. 2007 May;12(5):767-78.


Differential role of Rab proteins in ciliary trafficking: Rab23 regulates smoothened levels.

Boehlke C, Bashkurov M, Buescher A, Krick T, John AK, Nitschke R, Walz G, Kuehn EW.

J Cell Sci. 2010 May 1;123(Pt 9):1460-7. doi: 10.1242/jcs.058883. Epub 2010 Apr 7.


Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components.

Qin J, Lin Y, Norman RX, Ko HW, Eggenschwiler JT.

Proc Natl Acad Sci U S A. 2011 Jan 25;108(4):1456-61. doi: 10.1073/pnas.1011410108. Epub 2011 Jan 5.


Smoothened adopts multiple active and inactive conformations capable of trafficking to the primary cilium.

Wilson CW, Chen MH, Chuang PT.

PLoS One. 2009;4(4):e5182. doi: 10.1371/journal.pone.0005182. Epub 2009 Apr 13.


Lateral transport of Smoothened from the plasma membrane to the membrane of the cilium.

Milenkovic L, Scott MP, Rohatgi R.

J Cell Biol. 2009 Nov 2;187(3):365-74. doi: 10.1083/jcb.200907126. Epub 2009 Oct 26.


Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2.

Yang C, Chen W, Chen Y, Jiang J.

Cell Res. 2012 Nov;22(11):1593-604. doi: 10.1038/cr.2012.134. Epub 2012 Sep 18.


Distinct localization of septin proteins to ciliary sub-compartments in airway epithelial cells.

Fliegauf M, Kahle A, Häffner K, Zieger B.

Biol Chem. 2014 Feb;395(2):151-6.


Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling.

Garcia-Gonzalo FR, Phua SC, Roberson EC, Garcia G 3rd, Abedin M, Schurmans S, Inoue T, Reiter JF.

Dev Cell. 2015 Aug 24;34(4):400-409. doi: 10.1016/j.devcel.2015.08.001.


Pitchfork and Gprasp2 Target Smoothened to the Primary Cilium for Hedgehog Pathway Activation.

Jung B, Padula D, Burtscher I, Landerer C, Lutter D, Theis F, Messias AC, Geerlof A, Sattler M, Kremmer E, Boldt K, Ueffing M, Lickert H.

PLoS One. 2016 Feb 22;11(2):e0149477. doi: 10.1371/journal.pone.0149477. eCollection 2016.

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