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Items: 1 to 20 of 255

1.

Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease.

Strauss K, Goebel C, Runz H, Möbius W, Weiss S, Feussner I, Simons M, Schneider A.

J Biol Chem. 2010 Aug 20;285(34):26279-88. doi: 10.1074/jbc.M110.134775. Epub 2010 Jun 16.

2.

The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo.

Neufeld EB, Wastney M, Patel S, Suresh S, Cooney AM, Dwyer NK, Roff CF, Ohno K, Morris JA, Carstea ED, Incardona JP, Strauss JF 3rd, Vanier MT, Patterson MC, Brady RO, Pentchev PG, Blanchette-Mackie EJ.

J Biol Chem. 1999 Apr 2;274(14):9627-35.

3.

The Niemann-Pick C proteins and trafficking of cholesterol through the late endosomal/lysosomal system.

Garver WS, Heidenreich RA.

Curr Mol Med. 2002 Aug;2(5):485-505. Review.

PMID:
12125814
4.

Niemann-Pick type C mutations cause lipid traffic jam.

Liscum L.

Traffic. 2000 Mar;1(3):218-25. Review.

5.

Transmembrane molecular pump activity of Niemann-Pick C1 protein.

Davies JP, Chen FW, Ioannou YA.

Science. 2000 Dec 22;290(5500):2295-8.

6.

Cholesterol movement in Niemann-Pick type C cells and in cells treated with amphiphiles.

Lange Y, Ye J, Rigney M, Steck T.

J Biol Chem. 2000 Jun 9;275(23):17468-75.

7.

Niemann-Pick type C disease: importance of N-glycosylation sites for function and cellular location of the NPC2 protein.

Chikh K, Vey S, Simonot C, Vanier MT, Millat G.

Mol Genet Metab. 2004 Nov;83(3):220-30.

PMID:
15542393
8.

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.

Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, Cummings C, Gu J, Rosenfeld MA, Pavan WJ, Krizman DB, Nagle J, Polymeropoulos MH, Sturley SL, Ioannou YA, Higgins ME, Comly M, Cooney A, Brown A, Kaneski CR, Blanchette-Mackie EJ, Dwyer NK, Neufeld EB, Chang TY, Liscum L, Strauss JF 3rd, Ohno K, Zeigler M, Carmi R, Sokol J, Markie D, O'Neill RR, van Diggelen OP, Elleder M, Patterson MC, Brady RO, Vanier MT, Pentchev PG, Tagle DA.

Science. 1997 Jul 11;277(5323):228-31.

9.

Deficiency of niemann-pick type C-1 protein impairs release of human immunodeficiency virus type 1 and results in Gag accumulation in late endosomal/lysosomal compartments.

Tang Y, Leao IC, Coleman EM, Broughton RS, Hildreth JE.

J Virol. 2009 Aug;83(16):7982-95. doi: 10.1128/JVI.00259-09. Epub 2009 May 27.

10.

Depletion of rafts in late endocytic membranes is controlled by NPC1-dependent recycling of cholesterol to the plasma membrane.

Lusa S, Blom TS, Eskelinen EL, Kuismanen E, Månsson JE, Simons K, Ikonen E.

J Cell Sci. 2001 May;114(Pt 10):1893-900.

11.

Niemann-Pick C variant detection by altered sphingolipid trafficking and correlation with mutations within a specific domain of NPC1.

Sun X, Marks DL, Park WD, Wheatley CL, Puri V, O'Brien JF, Kraft DL, Lundquist PA, Patterson MC, Pagano RE, Snow K.

Am J Hum Genet. 2001 Jun;68(6):1361-72. Epub 2001 May 9.

12.

Sterol-modulated glycolipid sorting occurs in niemann-pick C1 late endosomes.

Zhang M, Dwyer NK, Neufeld EB, Love DC, Cooney A, Comly M, Patel S, Watari H, Strauss JF 3rd, Pentchev PG, Hanover JA, Blanchette-Mackie EJ.

J Biol Chem. 2001 Feb 2;276(5):3417-25. Epub 2000 Oct 13.

13.

ABCA1-dependent mobilization of lysosomal cholesterol requires functional Niemann-Pick C2 but not Niemann-Pick C1 protein.

Boadu E, Nelson RC, Francis GA.

Biochim Biophys Acta. 2012 Mar;1821(3):396-404. doi: 10.1016/j.bbalip.2011.11.013. Epub 2011 Dec 10.

PMID:
22179027
14.

Niemann-Pick type C disease: NPC1 mutations associated with severe and mild cellular cholesterol trafficking alterations.

Ribeiro I, Marcão A, Amaral O, Sá Miranda MC, Vanier MT, Millat G.

Hum Genet. 2001 Jul;109(1):24-32.

PMID:
11479732
15.

Adenovirus expressing an NPC1-GFP fusion gene corrects neuronal and nonneuronal defects associated with Niemann pick type C disease.

Paul CA, Reid PC, Boegle AK, Karten B, Zhang M, Jiang ZG, Franz D, Lin L, Chang TY, Vance JE, Blanchette-Mackie J, Maue RA.

J Neurosci Res. 2005 Sep 1;81(5):706-19.

PMID:
16015597
16.

Differential trafficking of the Niemann-Pick C1 and 2 proteins highlights distinct roles in late endocytic lipid trafficking.

Zhang M, Sun M, Dwyer NK, Comly ME, Patel SC, Sundaram R, Hanover JA, Blanchette-Mackie EJ.

Acta Paediatr Suppl. 2003 Dec;92(443):63-73; discussion 45.

PMID:
14989468
17.

NPC1-containing compartment of human granulosa-lutein cells: a role in the intracellular trafficking of cholesterol supporting steroidogenesis.

Watari H, Blanchette-Mackie EJ, Dwyer NK, Sun G, Glick JM, Patel S, Neufeld EB, Pentchev PG, Strauss JF 3rd.

Exp Cell Res. 2000 Feb 25;255(1):56-66.

PMID:
10666334
18.

Niemann-Pick C1 is a late endosome-resident protein that transiently associates with lysosomes and the trans-Golgi network.

Higgins ME, Davies JP, Chen FW, Ioannou YA.

Mol Genet Metab. 1999 Sep;68(1):1-13.

PMID:
10479477
19.

The Niemann-Pick C1 protein in feline fibroblasts.

Garver WS, Somers K, Krishnan K, Mitchell T, Heidenreich RA, Thrall MA.

Mol Genet Metab. 2002 May;76(1):31-6.

PMID:
12175778
20.

Defective endocytic trafficking of NPC1 and NPC2 underlying infantile Niemann-Pick type C disease.

Blom TS, Linder MD, Snow K, Pihko H, Hess MW, Jokitalo E, Veckman V, Syvänen AC, Ikonen E.

Hum Mol Genet. 2003 Feb 1;12(3):257-72.

PMID:
12554680

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