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Items: 1 to 20 of 395

2.

Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.

Kwon YE, Park JY, No KT, Shin JH, Lee SK, Eun JS, Yang JH, Shin TY, Kim DK, Chae BS, Leem JY, Kim KH.

Bioorg Med Chem. 2007 Oct 15;15(20):6596-607. Epub 2007 Jul 25.

PMID:
17681794
3.

Rivastigmine is a potent inhibitor of acetyl- and butyrylcholinesterase in Alzheimer's plaques and tangles.

Eskander MF, Nagykery NG, Leung EY, Khelghati B, Geula C.

Brain Res. 2005 Oct 26;1060(1-2):144-52. Epub 2005 Oct 5.

PMID:
16212945
4.

Structural insight into the inhibition of acetylcholinesterase by 2,3,4, 5-tetrahydro-1, 5-benzothiazepines.

Nawaz SA, Umbreen S, Kahlid A, Ansari FL, Choudhary MI.

J Enzyme Inhib Med Chem. 2008 Apr;23(2):206-12. doi: 10.1080/14756360701533080 .

PMID:
18343905
5.

Selective reversible inhibition of human butyrylcholinesterase by aryl amide derivatives of phenothiazine.

Darvesh S, McDonald RS, Darvesh KV, Mataija D, Conrad S, Gomez G, Walsh R, Martin E.

Bioorg Med Chem. 2007 Oct 1;15(19):6367-78. Epub 2007 Jul 6.

PMID:
17681768
6.

Molecular perception of interactions between bis(7)tacrine and cystamine-tacrine dimer with cholinesterases as the promising proposed agents for the treatment of Alzheimer's disease.

Eslami M, Hashemianzadeh SM, Bagherzadeh K, Seyed Sajadi SA.

J Biomol Struct Dyn. 2016;34(4):855-69. doi: 10.1080/07391102.2015.1057526. Epub 2015 Jul 8.

PMID:
26043757
7.

Cholinesterases inhibition and molecular modeling studies of piperidyl-thienyl and 2-pyrazoline derivatives of chalcones.

Shah MS, Khan SU, Ejaz SA, Afridi S, Rizvi SU, Najam-Ul-Haq M, Iqbal J.

Biochem Biophys Res Commun. 2017 Jan 22;482(4):615-624. doi: 10.1016/j.bbrc.2016.11.082. Epub 2016 Nov 16.

PMID:
27865835
8.

Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.

Tasso B, Catto M, Nicolotti O, Novelli F, Tonelli M, Giangreco I, Pisani L, Sparatore A, Boido V, Carotti A, Sparatore F.

Eur J Med Chem. 2011 Jun;46(6):2170-84. doi: 10.1016/j.ejmech.2011.02.071. Epub 2011 Mar 5.

PMID:
21459491
9.
10.

Solid-phase synthesis and biological evaluation of a parallel library of 2,3-dihydro-1,5-benzothiazepines.

Ansari FL, Iftikhar F, Ihsan-Ul-Haq, Mirza B, Baseer M, Rashid U.

Bioorg Med Chem. 2008 Aug 15;16(16):7691-7. doi: 10.1016/j.bmc.2008.07.009. Epub 2008 Jul 9.

PMID:
18650096
11.

Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.

Więckowska A, Więckowski K, Bajda M, Brus B, Sałat K, Czerwińska P, Gobec S, Filipek B, Malawska B.

Bioorg Med Chem. 2015 May 15;23(10):2445-57. doi: 10.1016/j.bmc.2015.03.051. Epub 2015 Mar 27.

PMID:
25868744
12.
13.

A gorge-spanning, high-affinity cholinesterase inhibitor to explore beta-amyloid plaques.

Elsinghorst PW, Härtig W, Goldhammer S, Grosche J, Gütschow M.

Org Biomol Chem. 2009 Oct 7;7(19):3940-6. doi: 10.1039/b909612d. Epub 2009 Jul 17.

PMID:
19763296
14.

Synthesis, molecular modeling and evaluation of novel N'-2-(4-benzylpiperidin-/piperazin-1-yl)acylhydrazone derivatives as dual inhibitors for cholinesterases and Aβ aggregation.

Özturan Özer E, Tan OU, Ozadali K, Küçükkılınç T, Balkan A, Uçar G.

Bioorg Med Chem Lett. 2013 Jan 15;23(2):440-3. doi: 10.1016/j.bmcl.2012.11.064. Epub 2012 Nov 28.

PMID:
23273219
17.

Multipotent MAO and cholinesterase inhibitors for the treatment of Alzheimer's disease: synthesis, pharmacological analysis and molecular modeling of heterocyclic substituted alkyl and cycloalkyl propargyl amine.

Samadi A, de los Ríos C, Bolea I, Chioua M, Iriepa I, Moraleda I, Bartolini M, Andrisano V, Gálvez E, Valderas C, Unzeta M, Marco-Contelles J.

Eur J Med Chem. 2012 Jun;52:251-62. doi: 10.1016/j.ejmech.2012.03.022. Epub 2012 Mar 30.

PMID:
22503231
18.

Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors.

Razavi SF, Khoobi M, Nadri H, Sakhteman A, Moradi A, Emami S, Foroumadi A, Shafiee A.

Eur J Med Chem. 2013 Jun;64:252-9. doi: 10.1016/j.ejmech.2013.03.021. Epub 2013 Mar 18.

PMID:
23644208
19.

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.

Nachon F, Carletti E, Ronco C, Trovaslet M, Nicolet Y, Jean L, Renard PY.

Biochem J. 2013 Aug 1;453(3):393-9. doi: 10.1042/BJ20130013.

PMID:
23679855
20.

Tacrine-flurbiprofen hybrids as multifunctional drug candidates for the treatment of Alzheimer's disease.

Chen Y, Sun J, Peng S, Liao H, Zhang Y, Lehmann J.

Arch Pharm (Weinheim). 2013 Dec;346(12):865-71. doi: 10.1002/ardp.201300074. Epub 2013 Nov 6.

PMID:
24203864

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