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Items: 1 to 20 of 119

1.

Targeted intracellular delivery of antisense oligonucleotides via conjugation with small-molecule ligands.

Nakagawa O, Ming X, Huang L, Juliano RL.

J Am Chem Soc. 2010 Jul 7;132(26):8848-9. doi: 10.1021/ja102635c.

2.

Targeted delivery of a splice-switching oligonucleotide by cationic polyplexes of RGD-oligonucleotide conjugate.

Ming X, Feng L.

Mol Pharm. 2012 May 7;9(5):1502-10. doi: 10.1021/mp300113c. Epub 2012 Apr 25.

3.

The biological effect of an antisense oligonucleotide depends on its route of endocytosis and trafficking.

Alam MR, Ming X, Dixit V, Fisher M, Chen X, Juliano RL.

Oligonucleotides. 2010 Apr;20(2):103-9. doi: 10.1089/oli.2009.0211.

4.

Conjugation with receptor-targeted histidine-rich peptides enhances the pharmacological effectiveness of antisense oligonucleotides.

Nakagawa O, Ming X, Carver K, Juliano R.

Bioconjug Chem. 2014 Jan 15;25(1):165-70. doi: 10.1021/bc400500h. Epub 2013 Dec 19.

5.
6.

Fragment-based solid-phase assembly of oligonucleotide conjugates with peptide and polyethylene glycol ligands.

Dirin M, Urban E, Noe CR, Winkler J.

Eur J Med Chem. 2016 Oct 4;121:132-142. doi: 10.1016/j.ejmech.2016.05.001. Epub 2016 May 3.

PMID:
27236069
7.

Intracellular delivery of an anionic antisense oligonucleotide via receptor-mediated endocytosis.

Alam MR, Dixit V, Kang H, Li ZB, Chen X, Trejo J, Fisher M, Juliano RL.

Nucleic Acids Res. 2008 May;36(8):2764-76. doi: 10.1093/nar/gkn115. Epub 2008 Mar 26.

8.

Intracellular delivery of an antisense oligonucleotide via endocytosis of a G protein-coupled receptor.

Ming X, Alam MR, Fisher M, Yan Y, Chen X, Juliano RL.

Nucleic Acids Res. 2010 Oct;38(19):6567-76. doi: 10.1093/nar/gkq534. Epub 2010 Jun 15.

9.

Improved cellular uptake of antisense peptide nucleic acids by conjugation to a cell-penetrating peptide and a lipid domain.

Shiraishi T, Nielsen PE.

Methods Mol Biol. 2011;751:209-21. doi: 10.1007/978-1-61779-151-2_13.

PMID:
21674333
10.

Controlled intracellular localization and enhanced antisense effect of oligonucleotides by chemical conjugation.

Kubo T, Zhelev Z, Bakalova R, Ohba H, Doi K, Fujii M.

Org Biomol Chem. 2005 Sep 21;3(18):3257-9. Epub 2005 Aug 15. Erratum in: Org Biomol Chem. 2005 Oct 7;3(19):3594. Rumiana, Bakalova [corrected to Bakalova, Rumiana].

PMID:
16132084
11.

Cellular uptake and intracellular trafficking of oligonucleotides: implications for oligonucleotide pharmacology.

Juliano RL, Ming X, Carver K, Laing B.

Nucleic Acid Ther. 2014 Apr;24(2):101-13. doi: 10.1089/nat.2013.0463. Epub 2014 Jan 2. Review.

12.

A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides.

Hussain M, Shchepinov M, Sohail M, Benter IF, Hollins AJ, Southern EM, Akhtar S.

J Control Release. 2004 Sep 14;99(1):139-55.

PMID:
15342187
13.

Enhanced cellular delivery of cell-penetrating peptide-peptide nucleic acid conjugates by photochemical internalization.

Shiraishi T, Nielsen PE.

Methods Mol Biol. 2011;683:391-7. doi: 10.1007/978-1-60761-919-2_28.

PMID:
21053145
14.

Cellular delivery and biological activity of antisense oligonucleotides conjugated to a targeted protein carrier.

Kang H, Alam MR, Dixit V, Fisher M, Juliano RL.

Bioconjug Chem. 2008 Nov 19;19(11):2182-8. doi: 10.1021/bc800270w.

15.

Recent preclinical and clinical advances in oligonucleotide conjugates.

Craig K, Abrams M, Amiji M.

Expert Opin Drug Deliv. 2018 Jun;15(6):629-640. doi: 10.1080/17425247.2018.1473375. Epub 2018 May 16. Review.

PMID:
29727206
16.

A novel concept for ligand attachment to oligonucleotides via a 2'-succinyl linker.

Winkler J, Urban E, Losert D, Wacheck V, Pehamberger H, Noe CR.

Nucleic Acids Res. 2004 Feb 2;32(2):710-8. Print 2004.

17.

Cellular uptake and intracellular trafficking of antisense and siRNA oligonucleotides.

Juliano RL, Ming X, Nakagawa O.

Bioconjug Chem. 2012 Feb 15;23(2):147-57. doi: 10.1021/bc200377d. Epub 2011 Oct 27. Review.

18.

Quantitative measurements and rational materials design for intracellular delivery of oligonucleotides.

Roth CM.

Biotechnol Prog. 2008 Jan-Feb;24(1):23-8. Epub 2007 Sep 22. Review.

PMID:
17887773
19.

The chemistry and biology of oligonucleotide conjugates.

Juliano RL, Ming X, Nakagawa O.

Acc Chem Res. 2012 Jul 17;45(7):1067-76. doi: 10.1021/ar2002123. Epub 2012 Feb 21.

20.

Findings questioning the involvement of Sigma-1 receptor in the uptake of anisamide-decorated particles.

Dasargyri A, Hervella P, Christiansen A, Proulx ST, Detmar M, Leroux JC.

J Control Release. 2016 Feb 28;224:229-238. doi: 10.1016/j.jconrel.2016.01.021. Epub 2016 Jan 13.

PMID:
26774218

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