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The resurgence of A2B adenosine receptor signaling.

Aherne CM, Kewley EM, Eltzschig HK.

Biochim Biophys Acta. 2011 May;1808(5):1329-39. doi: 10.1016/j.bbamem.2010.05.016. Epub 2010 May 28. Review.


Signaling through the A2B adenosine receptor dampens endotoxin-induced acute lung injury.

Schingnitz U, Hartmann K, Macmanus CF, Eckle T, Zug S, Colgan SP, Eltzschig HK.

J Immunol. 2010 May 1;184(9):5271-9. doi: 10.4049/jimmunol.0903035. Epub 2010 Mar 26.


Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury.

Hart ML, Jacobi B, Schittenhelm J, Henn M, Eltzschig HK.

J Immunol. 2009 Apr 1;182(7):3965-8. doi: 10.4049/jimmunol.0802193.


Adenosine A2B receptor modulates intestinal barrier function under hypoxic and ischemia/reperfusion conditions.

Yang Y, Qiu Y, Wang W, Xiao W, Liang H, Zhang C, Yang H, Teitelbaum DH, Sun LH, Yang H.

Int J Clin Exp Pathol. 2014 Apr 15;7(5):2006-18. eCollection 2014.


The Many Faces of the A2b Adenosine Receptor in Cardiovascular and Metabolic Diseases.

Eisenstein A, Patterson S, Ravid K.

J Cell Physiol. 2015 Dec;230(12):2891-7. doi: 10.1002/jcp.25043. Review.


A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice.

Eckle T, Grenz A, Laucher S, Eltzschig HK.

J Clin Invest. 2008 Oct;118(10):3301-15. doi: 10.1172/JCI34203.


A2B adenosine receptor dampens hypoxia-induced vascular leak.

Eckle T, Faigle M, Grenz A, Laucher S, Thompson LF, Eltzschig HK.

Blood. 2008 Feb 15;111(4):2024-35. Epub 2007 Dec 4.


The A2b adenosine receptor modulates glucose homeostasis and obesity.

Johnston-Cox H, Koupenova M, Yang D, Corkey B, Gokce N, Farb MG, LeBrasseur N, Ravid K.

PLoS One. 2012;7(7):e40584. doi: 10.1371/journal.pone.0040584. Epub 2012 Jul 25.


The hybrid molecule, VCP746, is a potent adenosine A2B receptor agonist that stimulates anti-fibrotic signalling.

Vecchio EA, Chuo CH, Baltos JA, Ford L, Scammells PJ, Wang BH, Christopoulos A, White PJ, May LT.

Biochem Pharmacol. 2016 Oct 1;117:46-56. doi: 10.1016/j.bcp.2016.08.007. Epub 2016 Aug 9.


Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-α signaling.

Chen H, Koupenova M, Yang D, Sume SS, Trackman PC, Ravid K.

Exp Hematol. 2011 May;39(5):525-30. doi: 10.1016/j.exphem.2011.02.004. Epub 2011 Feb 12.


Ligand-Independent Adenosine A2B Receptor Constitutive Activity as a Promoter of Prostate Cancer Cell Proliferation.

Vecchio EA, Tan CY, Gregory KJ, Christopoulos A, White PJ, May LT.

J Pharmacol Exp Ther. 2016 Apr;357(1):36-44. doi: 10.1124/jpet.115.230003. Epub 2016 Jan 20.


The macrophage A2B adenosine receptor regulates tissue insulin sensitivity.

Johnston-Cox H, Eisenstein AS, Koupenova M, Carroll S, Ravid K.

PLoS One. 2014 Jun 3;9(6):e98775. doi: 10.1371/journal.pone.0098775. eCollection 2014.


Targeting the A2B adenosine receptor during gastrointestinal ischemia and inflammation.

Eltzschig HK, Rivera-Nieves J, Colgan SP.

Expert Opin Ther Targets. 2009 Nov;13(11):1267-77. doi: 10.1517/14728220903241666. Review.


Capadenoson, a clinically trialed partial adenosine A1 receptor agonist, can stimulate adenosine A2B receptor biased agonism.

Baltos JA, Vecchio EA, Harris MA, Qin CX, Ritchie RH, Christopoulos A, White PJ, May LT.

Biochem Pharmacol. 2017 Jul 1;135:79-89. doi: 10.1016/j.bcp.2017.03.014. Epub 2017 Mar 23.


Actinin-1 binds to the C-terminus of A2B adenosine receptor (A2BAR) and enhances A2BAR cell-surface expression.

Sun Y, Hu W, Yu X, Liu Z, Tarran R, Ravid K, Huang P.

Biochem J. 2016 Jul 15;473(14):2179-86. doi: 10.1042/BCJ20160272. Epub 2016 May 17.


The reno-vascular A2B adenosine receptor protects the kidney from ischemia.

Grenz A, Osswald H, Eckle T, Yang D, Zhang H, Tran ZV, Klingel K, Ravid K, Eltzschig HK.

PLoS Med. 2008 Jun 24;5(6):e137. doi: 10.1371/journal.pmed.0050137.


Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury.

Sun CX, Zhong H, Mohsenin A, Morschl E, Chunn JL, Molina JG, Belardinelli L, Zeng D, Blackburn MR.

J Clin Invest. 2006 Aug;116(8):2173-2182.


Hypoxia-inducible factor-1α-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor.

Hart ML, Grenz A, Gorzolla IC, Schittenhelm J, Dalton JH, Eltzschig HK.

J Immunol. 2011 Apr 1;186(7):4367-74. doi: 10.4049/jimmunol.0903617. Epub 2011 Feb 28. Retraction in: J Immunol. 2017 Sep 1;199(5):1942.


Interplay of hypoxia and A2B adenosine receptors in tissue protection.

Koeppen M, Eckle T, Eltzschig HK.

Adv Pharmacol. 2011;61:145-86. doi: 10.1016/B978-0-12-385526-8.00006-0. Review.


An adenosine receptor-Krüppel-like factor 4 protein axis inhibits adipogenesis.

Eisenstein A, Carroll SH, Johnston-Cox H, Farb M, Gokce N, Ravid K.

J Biol Chem. 2014 Jul 25;289(30):21071-81.

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