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Items: 1 to 20 of 104


A novel strategy for therapeutic intervention for the genetic disease: preventing proteolytic cleavage using small chemical compound.

Yamada M, Hirotsune S, Wynshaw-Boris A.

Int J Biochem Cell Biol. 2010 Sep;42(9):1401-7. doi: 10.1016/j.biocel.2010.05.017. Epub 2010 Jun 9.


[Molecular mechanism of lissencephaly--how LIS1 and NDEL1 regulate cytoplasmic dynein?].

Hirotsune S.

Brain Nerve. 2008 Apr;60(4):375-81. Review. Japanese.


A unique role of dynein and nud family proteins in corticogenesis.

Toba S, Hirotsune S.

Neuropathology. 2012 Aug;32(4):432-9. doi: 10.1111/j.1440-1789.2012.01301.x. Epub 2012 Mar 7. Review.


Inhibition of calpain increases LIS1 expression and partially rescues in vivo phenotypes in a mouse model of lissencephaly.

Yamada M, Yoshida Y, Mori D, Takitoh T, Kengaku M, Umeshima H, Takao K, Miyakawa T, Sato M, Sorimachi H, Wynshaw-Boris A, Hirotsune S.

Nat Med. 2009 Oct;15(10):1202-7. doi: 10.1038/nm.2023. Epub 2009 Sep 6.


LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex.

Moon HM, Youn YH, Pemble H, Yingling J, Wittmann T, Wynshaw-Boris A.

Hum Mol Genet. 2014 Jan 15;23(2):449-66. doi: 10.1093/hmg/ddt436. Epub 2013 Sep 12.


Genetic enhancement of the Lis1+/- phenotype by a heterozygous mutation in the adenomatous polyposis coli gene.

Hebbar S, Guillotte AM, Mesngon MT, Zhou Q, Wynshaw-Boris A, Smith DS.

Dev Neurosci. 2008;30(1-3):157-70.


LIS1 and NDEL1 coordinate the plus-end-directed transport of cytoplasmic dynein.

Yamada M, Toba S, Yoshida Y, Haratani K, Mori D, Yano Y, Mimori-Kiyosue Y, Nakamura T, Itoh K, Fushiki S, Setou M, Wynshaw-Boris A, Torisawa T, Toyoshima YY, Hirotsune S.

EMBO J. 2008 Oct 8;27(19):2471-83. doi: 10.1038/emboj.2008.182. Epub 2008 Sep 11.


Lissencephaly: mechanistic insights from animal models and potential therapeutic strategies.

Wynshaw-Boris A, Pramparo T, Youn YH, Hirotsune S.

Semin Cell Dev Biol. 2010 Oct;21(8):823-30. doi: 10.1016/j.semcdb.2010.07.008. Epub 2010 Aug 3. Review.


LIS1 functions in normal development and disease.

Reiner O, Sapir T.

Curr Opin Neurobiol. 2013 Dec;23(6):951-6. doi: 10.1016/j.conb.2013.08.001. Epub 2013 Aug 23. Review.


The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagella.

Pedersen LB, Rompolas P, Christensen ST, Rosenbaum JL, King SM.

J Cell Sci. 2007 Mar 1;120(Pt 5):858-67.


[Molecular mechanism of lissencephaly: how LIS1 regulates cytoplasmic dynein].

Hirotsune S.

No To Hattatsu. 2008 May;40(3):208-12. Review. Japanese. No abstract available.


Functional dissection of LIS1 and NDEL1 towards understanding the molecular mechanisms of cytoplasmic dynein regulation.

Torisawa T, Nakayama A, Furuta K, Yamada M, Hirotsune S, Toyoshima YY.

J Biol Chem. 2011 Jan 21;286(3):1959-65. doi: 10.1074/jbc.M110.169847. Epub 2010 Oct 29.


Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice.

Youn YH, Pramparo T, Hirotsune S, Wynshaw-Boris A.

J Neurosci. 2009 Dec 9;29(49):15520-30. doi: 10.1523/JNEUROSCI.4630-09.2009.


Lis1 acts as a "clutch" between the ATPase and microtubule-binding domains of the dynein motor.

Huang J, Roberts AJ, Leschziner AE, Reck-Peterson SL.

Cell. 2012 Aug 31;150(5):975-86. doi: 10.1016/j.cell.2012.07.022.


ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice.

Sebe JY, Bershteyn M, Hirotsune S, Wynshaw-Boris A, Baraban SC.

J Neurophysiol. 2013 Jan;109(2):429-36. doi: 10.1152/jn.00431.2012. Epub 2012 Oct 24.


Functional analyses of lissencephaly-related proteins in Dictyostelium.

Meyer I, Kuhnert O, Gräf R.

Semin Cell Dev Biol. 2011 Feb;22(1):89-96. doi: 10.1016/j.semcdb.2010.10.007. Epub 2010 Oct 27. Review.


A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function.

Faulkner NE, Dujardin DL, Tai CY, Vaughan KT, O'Connell CB, Wang Y, Vallee RB.

Nat Cell Biol. 2000 Nov;2(11):784-91.


The L279P mutation of nuclear distribution gene C (NudC) influences its chaperone activity and lissencephaly protein 1 (LIS1) stability.

Zhu XJ, Liu X, Jin Q, Cai Y, Yang Y, Zhou T.

J Biol Chem. 2010 Sep 24;285(39):29903-10. doi: 10.1074/jbc.M110.105494. Epub 2010 Jul 30.


A Cdk5-dependent switch regulates Lis1/Ndel1/dynein-driven organelle transport in adult axons.

Pandey JP, Smith DS.

J Neurosci. 2011 Nov 23;31(47):17207-19. doi: 10.1523/JNEUROSCI.4108-11.2011.

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