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Items: 1 to 20 of 92

1.

Allosteric regulation of protease activity by small molecules.

Shen A.

Mol Biosyst. 2010 Aug;6(8):1431-43. doi: 10.1039/c003913f. Epub 2010 Jun 10. Review.

2.

Probing an Allosteric Pocket of CDK2 with Small Molecules.

Christodoulou MS, Caporuscio F, Restelli V, Carlino L, Cannazza G, Costanzi E, Citti C, Lo Presti L, Pisani P, Battistutta R, Broggini M, Passarella D, Rastelli G.

ChemMedChem. 2017 Jan 5;12(1):33-41. doi: 10.1002/cmdc.201600474. Epub 2016 Dec 19.

PMID:
27860401
3.

The potential for caspases in drug discovery.

MacKenzie SH, Schipper JL, Clark AC.

Curr Opin Drug Discov Devel. 2010 Sep;13(5):568-76. Review.

4.

Diversity of allosteric regulation in proteases.

Merdanovic M, Mönig T, Ehrmann M, Kaiser M.

ACS Chem Biol. 2013 Jan 18;8(1):19-26. doi: 10.1021/cb3005935. Epub 2012 Dec 3. Review.

PMID:
23181429
5.

Allosteric regulation of proteases.

Hauske P, Ottmann C, Meltzer M, Ehrmann M, Kaiser M.

Chembiochem. 2008 Dec 15;9(18):2920-8. doi: 10.1002/cbic.200800528. Review.

PMID:
19021141
6.

A bifunctional allosteric site in the dimer interface of procaspase-3.

Schipper JL, MacKenzie SH, Sharma A, Clark AC.

Biophys Chem. 2011 Nov;159(1):100-9. doi: 10.1016/j.bpc.2011.05.013. Epub 2011 May 25.

7.

A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases.

Dagbay K, Eron SJ, Serrano BP, Velázquez-Delgado EM, Zhao Y, Lin D, Vaidya S, Hardy JA.

Methods Enzymol. 2014;544:215-49. doi: 10.1016/B978-0-12-417158-9.00009-1.

8.

Overview of receptor allosterism.

Gregory KJ, Sexton PM, Christopoulos A.

Curr Protoc Pharmacol. 2010 Dec;Chapter 1:Unit 1.21. doi: 10.1002/0471141755.ph0121s51.

PMID:
21935895
9.
10.

Turning a protein kinase on or off from a single allosteric site via disulfide trapping.

Sadowsky JD, Burlingame MA, Wolan DW, McClendon CL, Jacobson MP, Wells JA.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6056-61. doi: 10.1073/pnas.1102376108. Epub 2011 Mar 23.

11.

Protease proteomics: revealing protease in vivo functions using systems biology approaches.

Doucet A, Overall CM.

Mol Aspects Med. 2008 Oct;29(5):339-58. doi: 10.1016/j.mam.2008.04.003. Epub 2008 May 1. Review.

PMID:
18571712
12.

Emerging principles in protease-based drug discovery.

Drag M, Salvesen GS.

Nat Rev Drug Discov. 2010 Sep;9(9):690-701. doi: 10.1038/nrd3053. Review.

13.

Discovery of an allosteric site in the caspases.

Hardy JA, Lam J, Nguyen JT, O'Brien T, Wells JA.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12461-6. Epub 2004 Aug 16.

14.

From G Protein-coupled Receptor Structure Resolution to Rational Drug Design.

Jazayeri A, Dias JM, Marshall FH.

J Biol Chem. 2015 Aug 7;290(32):19489-95. doi: 10.1074/jbc.R115.668251. Epub 2015 Jun 22. Review.

15.

Plasmin regulation through allosteric, sulfated, small molecules.

Al-Horani RA, Karuturi R, White DT, Desai UR.

Molecules. 2015 Jan 5;20(1):608-24. doi: 10.3390/molecules20010608.

16.

Activation and Allosteric Modulation of Human μ Opioid Receptor in Molecular Dynamics.

Bartuzi D, Kaczor AA, Matosiuk D.

J Chem Inf Model. 2015 Nov 23;55(11):2421-34. doi: 10.1021/acs.jcim.5b00280. Epub 2015 Nov 11.

PMID:
26517559
17.

Strategies for the identification of allosteric modulators of G-protein-coupled receptors.

Burford NT, Watson J, Bertekap R, Alt A.

Biochem Pharmacol. 2011 Mar 15;81(6):691-702. doi: 10.1016/j.bcp.2010.12.012. Epub 2010 Dec 22. Review.

PMID:
21184747
18.

Allosteric modulation of caspases.

Häcker HG, Sisay MT, Gütschow M.

Pharmacol Ther. 2011 Nov;132(2):180-95. doi: 10.1016/j.pharmthera.2011.07.003. Epub 2011 Jul 23. Review.

PMID:
21807025
19.

Docking of noncompetitive inhibitors into dengue virus type 2 protease: understanding the interactions with allosteric binding sites.

Othman R, Kiat TS, Khalid N, Yusof R, Newhouse EI, Newhouse JS, Alam M, Rahman NA.

J Chem Inf Model. 2008 Aug;48(8):1582-91. doi: 10.1021/ci700388k. Epub 2008 Jul 26.

PMID:
18656912
20.

Toward understanding the molecular basis for chemical allosteric modulator design.

Wang Q, Zheng M, Huang Z, Liu X, Zhou H, Chen Y, Shi T, Zhang J.

J Mol Graph Model. 2012 Sep;38:324-33. doi: 10.1016/j.jmgm.2012.07.006. Epub 2012 Aug 8.

PMID:
23085171

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