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Equilibrium between adenylyl cyclase and phosphodiesterase patterns adrenergic agonist dose-dependent spatiotemporal cAMP/protein kinase A activities in cardiomyocytes.

De Arcangelis V, Liu S, Zhang D, Soto D, Xiang YK.

Mol Pharmacol. 2010 Sep;78(3):340-9. doi: 10.1124/mol.110.064444. Epub 2010 Jun 7.


A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes.

Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK.

J Biol Chem. 2014 May 23;289(21):14771-81. doi: 10.1074/jbc.M113.542589. Epub 2014 Apr 8.


Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction.

Soto D, De Arcangelis V, Zhang J, Xiang Y.

Circ Res. 2009 Mar 27;104(6):770-9. doi: 10.1161/CIRCRESAHA.108.187880. Epub 2009 Feb 12.


Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases.

Leroy J, Abi-Gerges A, Nikolaev VO, Richter W, Lechêne P, Mazet JL, Conti M, Fischmeister R, Vandecasteele G.

Circ Res. 2008 May 9;102(9):1091-100. doi: 10.1161/CIRCRESAHA.107.167817. Epub 2008 Mar 27.


Regulation by phosphodiesterase isoforms of protein kinase A-mediated attenuation of myocardial protein kinase D activation.

Haworth RS, Cuello F, Avkiran M.

Basic Res Cardiol. 2011 Jan;106(1):51-63. doi: 10.1007/s00395-010-0116-1. Epub 2010 Aug 20.


Palmitoylation regulates intracellular trafficking of β2 adrenergic receptor/arrestin/phosphodiesterase 4D complexes in cardiomyocytes.

Liu R, Wang D, Shi Q, Fu Q, Hizon S, Xiang YK.

PLoS One. 2012;7(8):e42658. doi: 10.1371/journal.pone.0042658. Epub 2012 Aug 9.


cAMP-mediated beta-adrenergic signaling negatively regulates Gq-coupled receptor-mediated fetal gene response in cardiomyocytes.

Patrizio M, Vago V, Musumeci M, Fecchi K, Sposi NM, Mattei E, Catalano L, Stati T, Marano G.

J Mol Cell Cardiol. 2008 Dec;45(6):761-9. doi: 10.1016/j.yjmcc.2008.09.120. Epub 2008 Sep 25.


Differential association of phosphodiesterase 4D isoforms with beta2-adrenoceptor in cardiac myocytes.

De Arcangelis V, Liu R, Soto D, Xiang Y.

J Biol Chem. 2009 Dec 4;284(49):33824-32. doi: 10.1074/jbc.M109.020388. Epub 2009 Oct 1.


Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts.

Liu S, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6578-83. doi: 10.1073/pnas.1117862109. Epub 2012 Apr 9.


Agonist dose-dependent phosphorylation by protein kinase A and G protein-coupled receptor kinase regulates beta2 adrenoceptor coupling to G(i) proteins in cardiomyocytes.

Liu R, Ramani B, Soto D, De Arcangelis V, Xiang Y.

J Biol Chem. 2009 Nov 20;284(47):32279-87. doi: 10.1074/jbc.M109.021428. Epub 2009 Aug 25.


Compartmentalization of beta-adrenergic signals in cardiomyocytes.

Xiang YK.

Circ Res. 2011 Jul 8;109(2):231-44. doi: 10.1161/CIRCRESAHA.110.231340. Review.


Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes.

Haj Slimane Z, Bedioune I, Lechêne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G.

Cardiovasc Res. 2014 Apr 1;102(1):97-106. doi: 10.1093/cvr/cvu029. Epub 2014 Feb 18.


Interactions of Calcium Fluctuations during Cardiomyocyte Contraction with Real-Time cAMP Dynamics Detected by FRET.

Sprenger JU, Bork NI, Herting J, Fischer TH, Nikolaev VO.

PLoS One. 2016 Dec 8;11(12):e0167974. doi: 10.1371/journal.pone.0167974. eCollection 2016.


Negative feedback exerted by cAMP-dependent protein kinase and cAMP phosphodiesterase on subsarcolemmal cAMP signals in intact cardiac myocytes: an in vivo study using adenovirus-mediated expression of CNG channels.

Rochais F, Vandecasteele G, Lefebvre F, Lugnier C, Lum H, Mazet JL, Cooper DM, Fischmeister R.

J Biol Chem. 2004 Dec 10;279(50):52095-105. Epub 2004 Oct 1.


PKA-dependent activation of PDE3A and PDE4 and inhibition of adenylyl cyclase V/VI in smooth muscle.

Murthy KS, Zhou H, Makhlouf GM.

Am J Physiol Cell Physiol. 2002 Mar;282(3):C508-17.


Roles of GRK and PDE4 activities in the regulation of beta2 adrenergic signaling.

Xin W, Tran TM, Richter W, Clark RB, Rich TC.

J Gen Physiol. 2008 Apr;131(4):349-64. doi: 10.1085/jgp.200709881. Epub 2008 Mar 17.


FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes.

Liu S, Zhang J, Xiang YK.

Biochem Biophys Res Commun. 2011 Jan 14;404(2):581-6. doi: 10.1016/j.bbrc.2010.11.116. Epub 2010 Dec 3.

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