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DNAJB6 induces degradation of beta-catenin and causes partial reversal of mesenchymal phenotype.

Mitra A, Menezes ME, Shevde LA, Samant RS.

J Biol Chem. 2010 Aug 6;285(32):24686-94. doi: 10.1074/jbc.M109.094847. Epub 2010 Jun 3.


Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancer.

Mitra A, Fillmore RA, Metge BJ, Rajesh M, Xi Y, King J, Ju J, Pannell L, Shevde LA, Samant RS.

Breast Cancer Res. 2008;10(2):R22. doi: 10.1186/bcr1874. Epub 2008 Mar 7.


DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activity.

Menezes ME, Mitra A, Shevde LA, Samant RS.

Biochem J. 2012 Jun 15;444(3):573-80. doi: 10.1042/BJ20120205.


DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.

Mitra A, Menezes ME, Pannell LK, Mulekar MS, Honkanen RE, Shevde LA, Samant RS.

Oncogene. 2012 Oct 11;31(41):4472-83. doi: 10.1038/onc.2011.623. Epub 2012 Jan 23.


Heat shock proteins HSP70 and MRJ cooperatively regulate cell adhesion and migration through urokinase receptor.

Lin Y, Peng N, Zhuang H, Zhang D, Wang Y, Hua ZC.

BMC Cancer. 2014 Aug 30;14:639. doi: 10.1186/1471-2407-14-639.


KCl cotransporter-3 down-regulates E-cadherin/beta-catenin complex to promote epithelial-mesenchymal transition.

Hsu YM, Chen YF, Chou CY, Tang MJ, Chen JH, Wilkins RJ, Ellory JC, Shen MR.

Cancer Res. 2007 Nov 15;67(22):11064-73.


Interaction between urokinase receptor and heat shock protein MRJ enhances cell adhesion.

De Bock CE, Lin Z, Mekkawy AH, Byrne JA, Wang Y.

Int J Oncol. 2010 May;36(5):1155-63.


Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells.

Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH, Lung ML.

Gastroenterology. 2015 Dec;149(7):1825-1836.e5. doi: 10.1053/j.gastro.2015.08.025. Epub 2015 Aug 22.


Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.

Andrews JF, Sykora LJ, Letostak TB, Menezes ME, Mitra A, Barik S, Shevde LA, Samant RS.

Exp Cell Res. 2012 Jun 10;318(10):1086-93. doi: 10.1016/j.yexcr.2012.03.024. Epub 2012 Apr 3.


The Wnt antagonist Dkk1 regulates intestinal epithelial homeostasis and wound repair.

Koch S, Nava P, Addis C, Kim W, Denning TL, Li L, Parkos CA, Nusrat A.

Gastroenterology. 2011 Jul;141(1):259-68, 268.e1-8. doi: 10.1053/j.gastro.2011.03.043. Epub 2011 Mar 25.


Heat shock protein HSP40 family chaperone DNAJB6/MRJ expression analysis in blood cells obtained from patients with atopic dermatitis in different phases.

Elistratova IV, Ivanchenko OB, Grechko AV, Morozov SG.

Patol Fiziol Eksp Ter. 2016 Jul-Sep;60(3):23-30.


Wnt3a expression is associated with epithelial-mesenchymal transition and promotes colon cancer progression.

Qi L, Sun B, Liu Z, Cheng R, Li Y, Zhao X.

J Exp Clin Cancer Res. 2014 Dec 11;33:107. doi: 10.1186/s13046-014-0107-4.


OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors.

Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, Li BA.

Gastroenterology. 2016 Mar;150(3):659-671.e16. doi: 10.1053/j.gastro.2015.11.041. Epub 2015 Nov 24.


Inhibition of Wnt/β-catenin signaling promotes engraftment of mesenchymal stem cells to repair lung injury.

Sun Z, Gong X, Zhu H, Wang C, Xu X, Cui D, Qian W, Han X.

J Cell Physiol. 2014 Feb;229(2):213-24. doi: 10.1002/jcp.24436.


3,5,4'-Trimethoxystilbene, a natural methoxylated analog of resveratrol, inhibits breast cancer cell invasiveness by downregulation of PI3K/Akt and Wnt/β-catenin signaling cascades and reversal of epithelial-mesenchymal transition.

Tsai JH, Hsu LS, Lin CL, Hong HM, Pan MH, Way TD, Chen WJ.

Toxicol Appl Pharmacol. 2013 Nov 1;272(3):746-56. doi: 10.1016/j.taap.2013.07.019. Epub 2013 Aug 3.


Micro-RNA-632 downregulates DNAJB6 in breast cancer.

Mitra A, Rostas JW, Dyess DL, Shevde LA, Samant RS.

Lab Invest. 2012 Sep;92(9):1310-7. doi: 10.1038/labinvest.2012.87. Epub 2012 Jun 18.


Downregulation of β-catenin decreases the tumorigenicity, but promotes epithelial-mesenchymal transition in breast cancer cells.

Cai K, Jiang L, Wang J, Zhang H, Wang X, Cheng D, Dou J.

J Cancer Res Ther. 2014 Oct-Dec;10(4):1063-70. doi: 10.4103/0973-1482.139378.


The Mrj co-chaperone mediates keratin turnover and prevents the formation of toxic inclusion bodies in trophoblast cells of the placenta.

Watson ED, Geary-Joo C, Hughes M, Cross JC.

Development. 2007 May;134(9):1809-17. Epub 2007 Apr 4.


Nmi (N-Myc interactor) inhibits Wnt/beta-catenin signaling and retards tumor growth.

Fillmore RA, Mitra A, Xi Y, Ju J, Scammell J, Shevde LA, Samant RS.

Int J Cancer. 2009 Aug 1;125(3):556-64. doi: 10.1002/ijc.24276.


Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma.

Cheng Y, Cheung AK, Ko JM, Phoon YP, Chiu PM, Lo PH, Waterman ML, Lung ML.

BMC Cell Biol. 2013 Sep 27;14:44. doi: 10.1186/1471-2121-14-44.

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