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[Novel adaptor protein, STAP-2 functions as a signal modulator in immune system].

Sekine Y.

Yakugaku Zasshi. 2010 Jun;130(6):769-75. Review. Japanese.


Adaptor protein STAP-2 modulates cellular signaling in immune systems.

Sekine Y.

Biol Pharm Bull. 2014;37(2):185-94. Review.


Modulation of TLR4 signaling by a novel adaptor protein signal-transducing adaptor protein-2 in macrophages.

Sekine Y, Yumioka T, Yamamoto T, Muromoto R, Imoto S, Sugiyma K, Oritani K, Shimoda K, Minoguchi M, Akira S, Yoshimura A, Matsuda T.

J Immunol. 2006 Jan 1;176(1):380-9.


Physical and functional interactions between STAP-2/BKS and STAT5.

Sekine Y, Yamamoto T, Yumioka T, Sugiyama K, Tsuji S, Oritani K, Shimoda K, Minoguchi M, Yoshimura A, Matsuda T.

J Biol Chem. 2005 Mar 4;280(9):8188-96. Epub 2004 Dec 17.


STAP-2 negatively regulates both canonical and noncanonical NF-kappaB activation induced by Epstein-Barr virus-derived latent membrane protein 1.

Ikeda O, Sekine Y, Yasui T, Oritani K, Sugiyma K, Muromoto R, Ohbayashi N, Yoshimura A, Matsuda T.

Mol Cell Biol. 2008 Aug;28(16):5027-42. doi: 10.1128/MCB.00194-08. Epub 2008 Jun 23.


STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.

Minoguchi M, Minoguchi S, Aki D, Joo A, Yamamoto T, Yumioka T, Matsuda T, Yoshimura A.

J Biol Chem. 2003 Mar 28;278(13):11182-9. Epub 2003 Jan 22.


Signal-transducing adaptor protein-2 regulates stromal cell-derived factor-1 alpha-induced chemotaxis in T cells.

Sekine Y, Ikeda O, Tsuji S, Yamamoto C, Muromoto R, Nanbo A, Oritani K, Yoshimura A, Matsuda T.

J Immunol. 2009 Dec 15;183(12):7966-74. doi: 10.4049/jimmunol.0902096.


Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.

Sekine Y, Tsuji S, Ikeda O, Sugiyma K, Oritani K, Shimoda K, Muromoto R, Ohbayashi N, Yoshimura A, Matsuda T.

J Immunol. 2007 Aug 15;179(4):2397-407.


STAP-2 is phosphorylated at tyrosine-250 by Brk and modulates Brk-mediated STAT3 activation.

Ikeda O, Miyasaka Y, Sekine Y, Mizushima A, Muromoto R, Nanbo A, Yoshimura A, Matsuda T.

Biochem Biophys Res Commun. 2009 Jun 19;384(1):71-5. doi: 10.1016/j.bbrc.2009.04.076. Epub 2009 Apr 23.


STAP-2 regulates c-Fms/M-CSF receptor signaling in murine macrophage Raw 264.7 cells.

Ikeda O, Sekine Y, Kakisaka M, Tsuji S, Muromoto R, Ohbayashi N, Oritani K, Yoshimura A, Matsuda T.

Biochem Biophys Res Commun. 2007 Jul 6;358(3):931-7. Epub 2007 May 14.


Leukemia inhibitory factor-induced phosphorylation of STAP-2 on tyrosine-250 is involved in its STAT3-enhancing activity.

Sekine Y, Tsuji S, Ikeda O, Kakisaka M, Sugiyama K, Yoshimura A, Matsuda T.

Biochem Biophys Res Commun. 2007 May 4;356(2):517-22. Epub 2007 Mar 12.


Signal-transducing adaptor protein-2 regulates macrophage migration into inflammatory sites during dextran sodium sulfate induced colitis.

Fujita N, Oritani K, Ichii M, Yokota T, Saitoh N, Okuzaki D, Sekine Y, Kon S, Muromoto R, Saitoh K, Yoshimura A, Matsuda T, Kanakura Y.

Eur J Immunol. 2014 Jun;44(6):1791-801. doi: 10.1002/eji.201344239. Epub 2014 Apr 15.


Endotoxin-induced maturation of MyD88-deficient dendritic cells.

Kaisho T, Takeuchi O, Kawai T, Hoshino K, Akira S.

J Immunol. 2001 May 1;166(9):5688-94.


Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4.

Yamamoto M, Sato S, Hemmi H, Sanjo H, Uematsu S, Kaisho T, Hoshino K, Takeuchi O, Kobayashi M, Fujita T, Takeda K, Akira S.

Nature. 2002 Nov 21;420(6913):324-9.


Signal-transducing adaptor protein-2 controls the IgE-mediated, mast cell-mediated anaphylactic responses.

Sekine Y, Nishida K, Yamasaki S, Muromoto R, Kon S, Kashiwakura J, Saitoh K, Togi S, Yoshimura A, Oritani K, Matsuda T.

J Immunol. 2014 Apr 15;192(8):3488-95. doi: 10.4049/jimmunol.1300886. Epub 2014 Mar 10.


Complement C1q regulates LPS-induced cytokine production in bone marrow-derived dendritic cells.

Yamada M, Oritani K, Kaisho T, Ishikawa J, Yoshida H, Takahashi I, Kawamoto S, Ishida N, Ujiie H, Masaie H, Botto M, Tomiyama Y, Matsuzawa Y.

Eur J Immunol. 2004 Jan;34(1):221-30.


Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation.

Kaisho T, Hoshino K, Iwabe T, Takeuchi O, Yasui T, Akira S.

Int Immunol. 2002 Jul;14(7):695-700.


The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors.

Horng T, Barton GM, Flavell RA, Medzhitov R.

Nature. 2002 Nov 21;420(6913):329-33.


BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2.

Liu Y, Dong W, Chen L, Xiang R, Xiao H, De G, Wang Z, Qi Y.

J Biol Chem. 2004 Sep 3;279(36):37436-44. Epub 2004 Jun 22.

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