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Items: 1 to 20 of 100

1.

Ischemia induced peroxynitrite dependent modifications of cardiomyocyte MLC1 increases its degradation by MMP-2 leading to contractile dysfunction.

Polewicz D, Cadete VJ, Doroszko A, Hunter BE, Sawicka J, Szczesna-Cordary D, Light PE, Sawicki G.

J Cell Mol Med. 2011 May;15(5):1136-47. doi: 10.1111/j.1582-4934.2010.01094.x. Epub 2010 May 26.

2.

Ischemia/reperfusion-induced myosin light chain 1 phosphorylation increases its degradation by matrix metalloproteinase 2.

Cadete VJ, Sawicka J, Jaswal JS, Lopaschuk GD, Schulz R, Szczesna-Cordary D, Sawicki G.

FEBS J. 2012 Jul;279(13):2444-54. doi: 10.1111/j.1742-4658.2012.08622.x. Epub 2012 Jun 12.

3.

Inhibition of MMP-2 expression with siRNA increases baseline cardiomyocyte contractility and protects against simulated ischemic reperfusion injury.

Lin HB, Cadete VJ, Sra B, Sawicka J, Chen Z, Bekar LK, Cayabyab F, Sawicki G.

Biomed Res Int. 2014;2014:810371. doi: 10.1155/2014/810371. Epub 2014 Jul 24.

4.
5.

Cardiac dysfunction in an animal model of neonatal asphyxia is associated with increased degradation of MLC1 by MMP-2.

Doroszko A, Polewicz D, Sawicka J, Richardson JS, Cheung PY, Sawicki G.

Basic Res Cardiol. 2009 Nov;104(6):669-79. doi: 10.1007/s00395-009-0035-1. Epub 2009 May 19.

PMID:
19452190
6.

Inhibition of matrix metalloproteinases prevents peroxynitrite-induced contractile dysfunction in the isolated cardiac myocyte.

León H, Baczkó I, Sawicki G, Light PE, Schulz R.

Br J Pharmacol. 2008 Feb;153(4):676-83. Epub 2007 Dec 10.

7.

Titin is a target of matrix metalloproteinase-2: implications in myocardial ischemia/reperfusion injury.

Ali MA, Cho WJ, Hudson B, Kassiri Z, Granzier H, Schulz R.

Circulation. 2010 Nov 16;122(20):2039-47. doi: 10.1161/CIRCULATIONAHA.109.930222. Epub 2010 Nov 1.

8.

Inhibition of MMP-2 expression affects metabolic enzyme expression levels: proteomic analysis of rat cardiomyocytes.

Lin HB, Sharma K, Bialy D, Wawrzynska M, Purves R, Cayabyab FS, Wozniak M, Sawicki G.

J Proteomics. 2014 Jun 25;106:74-85. doi: 10.1016/j.jprot.2014.04.026. Epub 2014 Apr 24.

PMID:
24769238
9.

Degradation of cardiac myosin light chain kinase by matrix metalloproteinase-2 contributes to myocardial contractile dysfunction during ischemia/reperfusion.

Gao L, Zheng YJ, Gu SS, Tan JL, Paul C, Wang YG, Yang HT.

J Mol Cell Cardiol. 2014 Dec;77:102-12. doi: 10.1016/j.yjmcc.2014.10.004. Epub 2014 Oct 18.

PMID:
25451385
10.

Subthreshold nitric oxide synthase inhibition improves synergistic effects of subthreshold MMP-2/MLCK-mediated cardiomyocyte protection from hypoxic injury.

Bil-Lula I, Lin HB, Biały D, Wawrzyńska M, Diebel L, Sawicka J, Woźniak M, Sawicki G.

J Cell Mol Med. 2016 Jun;20(6):1086-94. doi: 10.1111/jcmm.12827. Epub 2016 Mar 17.

11.

Degradation of myosin light chain in isolated rat hearts subjected to ischemia-reperfusion injury: a new intracellular target for matrix metalloproteinase-2.

Sawicki G, Leon H, Sawicka J, Sariahmetoglu M, Schulze CJ, Scott PG, Szczesna-Cordary D, Schulz R.

Circulation. 2005 Jul 26;112(4):544-52. Epub 2005 Jul 18.

PMID:
16027249
13.

Peroxynitrite-induced myocardial injury is mediated through matrix metalloproteinase-2.

Wang W, Sawicki G, Schulz R.

Cardiovasc Res. 2002 Jan;53(1):165-74.

PMID:
11744025
14.

Matrix metalloproteinase-2 degrades the cytoskeletal protein alpha-actinin in peroxynitrite mediated myocardial injury.

Sung MM, Schulz CG, Wang W, Sawicki G, Bautista-López NL, Schulz R.

J Mol Cell Cardiol. 2007 Oct;43(4):429-36. Epub 2007 Jul 31.

PMID:
17854826
15.

Matrix metalloproteinase-2 is activated during ischemia/reperfusion in a model of myocardial infarction.

Cadete VJ, Arcand SA, Chaharyn BM, Doroszko A, Sawicka J, Mousseau DD, Sawicki G.

Can J Cardiol. 2013 Nov;29(11):1495-503. doi: 10.1016/j.cjca.2013.03.014. Epub 2013 Jun 13.

PMID:
23770015
16.

Role of iNOS-derived reactive nitrogen species and resultant nitrative stress in leukocytes-induced cardiomyocyte apoptosis after myocardial ischemia/reperfusion.

Wang XL, Liu HR, Tao L, Liang F, Yan L, Zhao RR, Lopez BL, Christopher TA, Ma XL.

Apoptosis. 2007 Jul;12(7):1209-17.

PMID:
17333318
17.

Tyrosine nitration of voltage-dependent anion channels in cardiac ischemia-reperfusion: reduction by peroxynitrite scavenging.

Yang M, Camara AK, Wakim BT, Zhou Y, Gadicherla AK, Kwok WM, Stowe DF.

Biochim Biophys Acta. 2012 Nov;1817(11):2049-59. doi: 10.1016/j.bbabio.2012.06.004. Epub 2012 Jun 15.

18.

Peroxynitrite inhibits myofibrillar protein function in an in vitro assay of motility.

Snook JH, Li J, Helmke BP, Guilford WH.

Free Radic Biol Med. 2008 Jan 1;44(1):14-23. Epub 2007 Sep 26.

20.

Inhibiting matrix metalloproteinase-2 reduces protein release into coronary effluent from isolated rat hearts during ischemia-reperfusion.

Fert-Bober J, Leon H, Sawicka J, Basran RS, Devon RM, Schulz R, Sawicki G.

Basic Res Cardiol. 2008 Sep;103(5):431-43. doi: 10.1007/s00395-008-0727-y. Epub 2008 May 28.

PMID:
18512095

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