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Items: 1 to 20 of 121


Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kappaB activation.

Wang P, Zhu F, Lee NH, Konstantopoulos K.

J Biol Chem. 2010 Aug 6;285(32):24793-804. doi: 10.1074/jbc.M110.110320. Epub 2010 Jun 1.


Prostaglandin E2 induces interleukin-6 expression in human chondrocytes via cAMP/protein kinase A- and phosphatidylinositol 3-kinase-dependent NF-kappaB activation.

Wang P, Zhu F, Konstantopoulos K.

Am J Physiol Cell Physiol. 2010 Jun;298(6):C1445-56. doi: 10.1152/ajpcell.00508.2009. Epub 2010 Mar 24.


Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1.

Wang P, Zhu F, Tong Z, Konstantopoulos K.

FASEB J. 2011 Oct;25(10):3401-15. doi: 10.1096/fj.11-184861. Epub 2011 Jun 29.


The role of cyclooxygenase-2, interleukin-1β and fibroblast growth factor-2 in the activation of matrix metalloproteinase-1 in sheared-chondrocytes and articular cartilage.

Guan PP, Guo JW, Yu X, Wang Y, Wang T, Konstantopoulos K, Wang ZY, Wang P.

Sci Rep. 2015 May 20;5:10412. doi: 10.1038/srep10412.


Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ(12,14)-PGJ2.

Wang P, Zhu F, Konstantopoulos K.

PLoS One. 2011;6(11):e27630. doi: 10.1371/journal.pone.0027630. Epub 2011 Nov 11.


Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases.

Zhu F, Wang P, Kontrogianni-Konstantopoulos A, Konstantopoulos K.

Cell Death Differ. 2010 Aug;17(8):1325-34. doi: 10.1038/cdd.2010.13. Epub 2010 Feb 12.


Effects of mechanical strain on the function of Gap junctions in osteocytes are mediated through the prostaglandin EP2 receptor.

Cherian PP, Cheng B, Gu S, Sprague E, Bonewald LF, Jiang JX.

J Biol Chem. 2003 Oct 31;278(44):43146-56. Epub 2003 Aug 25.


Aggravation of Alzheimer's disease due to the COX-2-mediated reciprocal regulation of IL-1β and Aβ between glial and neuron cells.

Wang P, Guan PP, Wang T, Yu X, Guo JJ, Wang ZY.

Aging Cell. 2014 Aug;13(4):605-15. doi: 10.1111/acel.12209. Epub 2014 Mar 13.


Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways.

Kitase Y, Barragan L, Qing H, Kondoh S, Jiang JX, Johnson ML, Bonewald LF.

J Bone Miner Res. 2010 Dec;25(12):2657-68. doi: 10.1002/jbmr.168. Epub 2010 Jun 24. Erratum in: J Bone Miner Res. 2011 Feb;26(2):439.


Divergent responses of chondrocytes and endothelial cells to shear stress: cross-talk among COX-2, the phase 2 response, and apoptosis.

Healy ZR, Lee NH, Gao X, Goldring MB, Talalay P, Kensler TW, Konstantopoulos K.

Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14010-5. Epub 2005 Sep 19.


Delphinidin inhibits IL-1β-induced activation of NF-κB by modulating the phosphorylation of IRAK-1(Ser376) in human articular chondrocytes.

Haseeb A, Chen D, Haqqi TM.

Rheumatology (Oxford). 2013 Jun;52(6):998-1008. doi: 10.1093/rheumatology/kes363. Epub 2013 Feb 7.


IGF-1 and PDGF-bb suppress IL-1β-induced cartilage degradation through down-regulation of NF-κB signaling: involvement of Src/PI-3K/AKT pathway.

Montaseri A, Busch F, Mobasheri A, Buhrmann C, Aldinger C, Rad JS, Shakibaei M.

PLoS One. 2011;6(12):e28663. doi: 10.1371/journal.pone.0028663. Epub 2011 Dec 14.


Prostanoid EP₁ receptors mediate up-regulation of the orphan nuclear receptor Nurr1 by cAMP-independent activation of protein kinase A, CREB and NF-κB.

Ji R, Sanchez CM, Chou CL, Chen XB, Woodward DF, Regan JW.

Br J Pharmacol. 2012 Jun;166(3):1033-46. doi: 10.1111/j.1476-5381.2011.01817.x.


Prostaglandin EP2 receptor signalling inhibits the expression of matrix metalloproteinase 13 in human osteoarthritic chondrocytes.

Sato T, Konomi K, Fujii R, Aono H, Aratani S, Yagishita N, Araya N, Yudoh K, Beppu M, Yamano Y, Nishioka K, Nakajima T.

Ann Rheum Dis. 2011 Jan;70(1):221-6. doi: 10.1136/ard.2009.118620. Epub 2010 Sep 24.


Prostaglandin E2 and its cognate EP receptors control human adult articular cartilage homeostasis and are linked to the pathophysiology of osteoarthritis.

Li X, Ellman M, Muddasani P, Wang JH, Cs-Szabo G, van Wijnen AJ, Im HJ.

Arthritis Rheum. 2009 Feb;60(2):513-23. doi: 10.1002/art.24258.


Prolonged application of high fluid shear to chondrocytes recapitulates gene expression profiles associated with osteoarthritis.

Zhu F, Wang P, Lee NH, Goldring MB, Konstantopoulos K.

PLoS One. 2010 Dec 29;5(12):e15174. doi: 10.1371/journal.pone.0015174.

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