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Items: 1 to 20 of 108

1.

A flippase-independent function of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1, is required for apical protein expression and microvillus formation in polarized epithelial cells.

Verhulst PM, van der Velden LM, Oorschot V, van Faassen EE, Klumperman J, Houwen RH, Pomorski TG, Holthuis JC, Klomp LW.

Hepatology. 2010 Jun;51(6):2049-60. doi: 10.1002/hep.23586.

PMID:
20512993
2.

Liver disease without flipping: new functions of ATP8B1, the protein affected in familial intrahepatic cholestasis type 1.

Dawson PA.

Hepatology. 2010 Jun;51(6):1885-7. doi: 10.1002/hep.23662. No abstract available.

3.

The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells.

van der Mark VA, de Waart DR, Ho-Mok KS, Tabbers MM, Voogt HW, Oude Elferink RP, Knisely AS, Paulusma CC.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2378-86. doi: 10.1016/j.bbadis.2014.09.003. Epub 2014 Sep 16.

4.

ATP8B1 deficiency disrupts the bile canalicular membrane bilayer structure in hepatocytes, but FXR expression and activity are maintained.

Cai SY, Gautam S, Nguyen T, Soroka CJ, Rahner C, Boyer JL.

Gastroenterology. 2009 Mar;136(3):1060-9. doi: 10.1053/j.gastro.2008.10.025. Epub 2008 Nov 1.

5.

Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport.

Paulusma CC, Groen A, Kunne C, Ho-Mok KS, Spijkerboer AL, Rudi de Waart D, Hoek FJ, Vreeling H, Hoeben KA, van Marle J, Pawlikowska L, Bull LN, Hofmann AF, Knisely AS, Oude Elferink RP.

Hepatology. 2006 Jul;44(1):195-204.

PMID:
16799980
6.

Differential effects of progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mutations on canalicular localization of ATP8B1.

Folmer DE, van der Mark VA, Ho-Mok KS, Oude Elferink RP, Paulusma CC.

Hepatology. 2009 Nov;50(5):1597-605. doi: 10.1002/hep.23158.

PMID:
19731236
7.

Progressive familial intrahepatic cholestasis type 1.

Paulusma CC, Elferink RP, Jansen PL.

Semin Liver Dis. 2010 May;30(2):117-24. doi: 10.1055/s-0030-1253221. Epub 2010 Apr 26. Review.

PMID:
20422494
8.

Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity.

Chen F, Ananthanarayanan M, Emre S, Neimark E, Bull LN, Knisely AS, Strautnieks SS, Thompson RJ, Magid MS, Gordon R, Balasubramanian N, Suchy FJ, Shneider BL.

Gastroenterology. 2004 Mar;126(3):756-64.

PMID:
14988830
9.

Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrate.

van der Velden LM, Stapelbroek JM, Krieger E, van den Berghe PV, Berger R, Verhulst PM, Holthuis JC, Houwen RH, Klomp LW, van de Graaf SF.

Hepatology. 2010 Jan;51(1):286-96. doi: 10.1002/hep.23268.

PMID:
19918981
10.

Familial intrahepatic cholestasis 1: studies of localization and function.

Ujhazy P, Ortiz D, Misra S, Li S, Moseley J, Jones H, Arias IM.

Hepatology. 2001 Oct;34(4 Pt 1):768-75. Erratum in: Hepatology 2002 Jan;35(1):246.

PMID:
11584374
11.

Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content.

Paulusma CC, de Waart DR, Kunne C, Mok KS, Elferink RP.

J Biol Chem. 2009 Apr 10;284(15):9947-54. doi: 10.1074/jbc.M808667200. Epub 2009 Feb 19.

12.

ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function.

Naik J, de Waart DR, Utsunomiya K, Duijst S, Mok KH, Oude Elferink RP, Bosma PJ, Paulusma CC.

Dig Dis. 2015;33(3):314-8. doi: 10.1159/000371665. Epub 2015 May 27.

PMID:
26045263
13.

Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane.

Takatsu H, Tanaka G, Segawa K, Suzuki J, Nagata S, Nakayama K, Shin HW.

J Biol Chem. 2014 Nov 28;289(48):33543-56. doi: 10.1074/jbc.M114.593012. Epub 2014 Oct 14. Erratum in: J Biol Chem. 2016 Oct 7;291(41):21421.

14.

Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity.

Groen A, Romero MR, Kunne C, Hoosdally SJ, Dixon PH, Wooding C, Williamson C, Seppen J, Van den Oever K, Mok KS, Paulusma CC, Linton KJ, Oude Elferink RP.

Gastroenterology. 2011 Nov;141(5):1927-37.e1-4. doi: 10.1053/j.gastro.2011.07.042. Epub 2011 Aug 4.

PMID:
21820390
15.

Protein-mediated inward translocation of phospholipids occurs in both the apical and basolateral plasma membrane domains of epithelial cells.

Pomorski T, Herrmann A, Müller P, van Meer G, Burger K.

Biochemistry. 1999 Jan 5;38(1):142-50.

PMID:
9890892
16.

Altered hepatobiliary gene expressions in PFIC1: ATP8B1 gene defect is associated with CFTR downregulation.

Demeilliers C, Jacquemin E, Barbu V, Mergey M, Paye F, Fouassier L, Chignard N, Housset C, Lomri NE.

Hepatology. 2006 May;43(5):1125-34.

PMID:
16628629
17.

[Childhood cholestasis and bile transporters].

Hierro L, Jara P.

Gastroenterol Hepatol. 2005 Aug-Sep;28(7):388-95. Review. Spanish.

PMID:
16137474
18.

Progressive familial intrahepatic cholestasis: genetic disorders of biliary transporters.

Harris MJ, Le Couteur DG, Arias IM.

J Gastroenterol Hepatol. 2005 Jun;20(6):807-17. Review.

PMID:
15946126
19.

ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity.

Paulusma CC, Folmer DE, Ho-Mok KS, de Waart DR, Hilarius PM, Verhoeven AJ, Oude Elferink RP.

Hepatology. 2008 Jan;47(1):268-78.

PMID:
17948906
20.

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