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Items: 1 to 20 of 86

1.

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans.

Burns AR, Wallace IM, Wildenhain J, Tyers M, Giaever G, Bader GD, Nislow C, Cutler SR, Roy PJ.

Nat Chem Biol. 2010 Jul;6(7):549-57. doi: 10.1038/nchembio.380. Epub 2010 May 30.

PMID:
20512140
2.

High-throughput screening of small molecules for bioactivity and target identification in Caenorhabditis elegans.

Burns AR, Kwok TC, Howard A, Houston E, Johanson K, Chan A, Cutler SR, McCourt P, Roy PJ.

Nat Protoc. 2006;1(4):1906-14.

PMID:
17487175
3.

Caenorhabditis elegans: a versatile platform for drug discovery.

Artal-Sanz M, de Jong L, Tavernarakis N.

Biotechnol J. 2006 Dec;1(12):1405-18. Review.

PMID:
17109493
4.

Knockdown of the NHR-8 nuclear receptor enhanced sensitivity to the lipid-reducing activity of alkaloids in Caenorhabditis elegans.

Chow YL, Kawasaki Y, Sato F.

Biosci Biotechnol Biochem. 2014;78(12):2008-13. doi: 10.1080/09168451.2014.940278. Epub 2014 Jul 23.

PMID:
25052035
5.

An update on the use of C. elegans for preclinical drug discovery: screening and identifying anti-infective drugs.

Kim W, Hendricks GL, Lee K, Mylonakis E.

Expert Opin Drug Discov. 2017 Jun;12(6):625-633. doi: 10.1080/17460441.2017.1319358. Epub 2017 Apr 21. Review.

PMID:
28402221
6.

Quantitatively integrating molecular structure and bioactivity profile evidence into drug-target relationship analysis.

Xu T, Zhu R, Liu Q, Cao Z.

BMC Bioinformatics. 2012 May 4;13:75. doi: 10.1186/1471-2105-13-75.

7.

High-throughput small-molecule screening in Caenorhabditis elegans.

Rangaraju S, Solis GM, Petrascheck M.

Methods Mol Biol. 2015;1263:139-55. doi: 10.1007/978-1-4939-2269-7_11.

PMID:
25618342
8.

Drug discovery: here comes the worm.

Ségalat L.

ACS Chem Biol. 2006 Jun 20;1(5):277-8. Review.

PMID:
17163755
9.

Caenorhabditis elegans as a chemical screening tool for the study o f neuromuscular disorders. Manual and semi-automated methods.

Giacomotto J, Ségalat L, Carre-Pierrat M, Gieseler K.

Methods. 2012 Jan;56(1):103-13. doi: 10.1016/j.ymeth.2011.10.010. Epub 2011 Oct 21.

PMID:
22041718
10.

Automated high-content live animal drug screening using C. elegans expressing the aggregation prone serpin α1-antitrypsin Z.

Gosai SJ, Kwak JH, Luke CJ, Long OS, King DE, Kovatch KJ, Johnston PA, Shun TY, Lazo JS, Perlmutter DH, Silverman GA, Pak SC.

PLoS One. 2010 Nov 12;5(11):e15460. doi: 10.1371/journal.pone.0015460.

11.

Chemistry and the worm: Caenorhabditis elegans as a platform for integrating chemical and biological research.

Hulme SE, Whitesides GM.

Angew Chem Int Ed Engl. 2011 May 16;50(21):4774-807. doi: 10.1002/anie.201005461. Epub 2011 Apr 15. Review.

PMID:
21500322
12.

[A worm's life].

Pujol N, Ewbank JJ.

Med Sci (Paris). 2003 Dec;19(12):1209-17. Review. French.

13.

Measuring Caenorhabditis elegans life span in 96 well microtiter plates.

Solis GM, Petrascheck M.

J Vis Exp. 2011 Mar 18;(49). pii: 2496. doi: 10.3791/2496.

14.

Drug-likeness and increased hydrophobicity of commercially available compound libraries for drug screening.

Zuegg J, Cooper MA.

Curr Top Med Chem. 2012;12(14):1500-13. Review.

PMID:
22827520
15.

Is Caenorhabditis elegans the Magic Bullet for Anthelminthic Drug Discovery?

Keiser J.

Trends Parasitol. 2015 Oct;31(10):455-6. doi: 10.1016/j.pt.2015.08.004. Epub 2015 Sep 25.

PMID:
26422771
16.

CO2 and compressive immobilization of C. elegans on-chip.

Chokshi TV, Ben-Yakar A, Chronis N.

Lab Chip. 2009 Jan 7;9(1):151-7. doi: 10.1039/b807345g. Epub 2008 Oct 21.

PMID:
19209348
17.

Chemical detoxification of small molecules by Caenorhabditis elegans.

Stupp GS, von Reuss SH, Izrayelit Y, Ajredini R, Schroeder FC, Edison AS.

ACS Chem Biol. 2013 Feb 15;8(2):309-13. doi: 10.1021/cb300520u. Epub 2012 Nov 26.

18.

Identification of compounds with bioactivity against the nematode Caenorhabditis elegans by a screen based on the functional genomics of the marine bacterium Pseudoalteromonas tunicata D2.

Ballestriero F, Thomas T, Burke C, Egan S, Kjelleberg S.

Appl Environ Microbiol. 2010 Sep;76(17):5710-7. doi: 10.1128/AEM.00695-10. Epub 2010 Jul 2.

19.

A small-molecule screen in C. elegans yields a new calcium channel antagonist.

Kwok TC, Ricker N, Fraser R, Chan AW, Burns A, Stanley EF, McCourt P, Cutler SR, Roy PJ.

Nature. 2006 May 4;441(7089):91-5.

PMID:
16672971
20.

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