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Elevated systemic TGF-beta impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(-/-) mice.

Buday A, Orsy P, Godó M, Mózes M, Kökény G, Lacza Z, Koller A, Ungvári Z, Gross ML, Benyó Z, Hamar P.

Am J Physiol Heart Circ Physiol. 2010 Aug;299(2):H386-95. doi: 10.1152/ajpheart.01042.2009. Epub 2010 May 28.


Endothelial-specific Nox2 overexpression increases vascular superoxide and macrophage recruitment in ApoE⁻/⁻ mice.

Douglas G, Bendall JK, Crabtree MJ, Tatham AL, Carter EE, Hale AB, Channon KM.

Cardiovasc Res. 2012 Apr 1;94(1):20-9. doi: 10.1093/cvr/cvs026. Epub 2012 Jan 27.


Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice.

Judkins CP, Diep H, Broughton BR, Mast AE, Hooker EU, Miller AA, Selemidis S, Dusting GJ, Sobey CG, Drummond GR.

Am J Physiol Heart Circ Physiol. 2010 Jan;298(1):H24-32. doi: 10.1152/ajpheart.00799.2009. Epub 2009 Oct 16.


Reactive Oxygen Species Can Provide Atheroprotection via NOX4-Dependent Inhibition of Inflammation and Vascular Remodeling.

Gray SP, Di Marco E, Kennedy K, Chew P, Okabe J, El-Osta A, Calkin AC, Biessen EA, Touyz RM, Cooper ME, Schmidt HH, Jandeleit-Dahm KA.

Arterioscler Thromb Vasc Biol. 2016 Feb;36(2):295-307. doi: 10.1161/ATVBAHA.115.307012. Epub 2015 Dec 29.


A peptide antagonist of thrombospondin-1 promotes abdominal aortic aneurysm progression in the angiotensin II-infused apolipoprotein-E-deficient mouse.

Krishna SM, Seto SW, Jose RJ, Biros E, Moran CS, Wang Y, Clancy P, Golledge J.

Arterioscler Thromb Vasc Biol. 2015 Feb;35(2):389-98. doi: 10.1161/ATVBAHA.114.304732. Epub 2014 Dec 18.


Superoxide dismutase mimetic M40403 improves endothelial function in apolipoprotein(E)-deficient mice.

Jiang F, Guo Y, Salvemini D, Dusting GJ.

Br J Pharmacol. 2003 Jul;139(6):1127-34.


AMPKalpha2 deletion causes aberrant expression and activation of NAD(P)H oxidase and consequent endothelial dysfunction in vivo: role of 26S proteasomes.

Wang S, Zhang M, Liang B, Xu J, Xie Z, Liu C, Viollet B, Yan D, Zou MH.

Circ Res. 2010 Apr 2;106(6):1117-28. doi: 10.1161/CIRCRESAHA.109.212530. Epub 2010 Feb 18.


gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension.

Jung O, Schreiber JG, Geiger H, Pedrazzini T, Busse R, Brandes RP.

Circulation. 2004 Apr 13;109(14):1795-801. Epub 2004 Mar 22.


Augmented superoxide production by Nox2-containing NADPH oxidase causes cerebral artery dysfunction during hypercholesterolemia.

Miller AA, De Silva TM, Judkins CP, Diep H, Drummond GR, Sobey CG.

Stroke. 2010 Apr;41(4):784-9. doi: 10.1161/STROKEAHA.109.575365. Epub 2010 Feb 18.


Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation.

Miriyala S, Gongora Nieto MC, Mingone C, Smith D, Dikalov S, Harrison DG, Jo H.

Circulation. 2006 Jun 20;113(24):2818-25. Epub 2006 Jun 12.


Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein.

d'Uscio LV, Das P, Santhanam AV, He T, Younkin SG, Katusic ZS.

Cardiovasc Res. 2012 Dec 1;96(3):504-12. doi: 10.1093/cvr/cvs266. Epub 2012 Aug 10.


OxLDL triggers retrograde translocation of arginase2 in aortic endothelial cells via ROCK and mitochondrial processing peptidase.

Pandey D, Bhunia A, Oh YJ, Chang F, Bergman Y, Kim JH, Serbo J, Boronina TN, Cole RN, Van Eyk J, Remaley AT, Berkowitz DE, Romer LH.

Circ Res. 2014 Aug 1;115(4):450-9. doi: 10.1161/CIRCRESAHA.115.304262. Epub 2014 Jun 5.


Evidence that nitric oxide inhibits vascular inflammation and superoxide production via a p47phox-dependent mechanism in mice.

Harrison CB, Drummond GR, Sobey CG, Selemidis S.

Clin Exp Pharmacol Physiol. 2010 Apr;37(4):429-34. doi: 10.1111/j.1440-1681.2009.05317.x. Epub 2009 Oct 16.


Heart rate reduction with ivabradine improves erectile dysfunction in parallel to decrease in atherosclerotic plaque load in ApoE-knockout mice.

Baumhäkel M, Custodis F, Schlimmer N, Laufs U, Böhm M.

Atherosclerosis. 2010 Sep;212(1):55-62. doi: 10.1016/j.atherosclerosis.2010.03.002. Epub 2010 Mar 9.


TGF-[beta]1 limits plaque growth, stabilizes plaque structure, and prevents aortic dilation in apolipoprotein E-null mice.

Frutkin AD, Otsuka G, Stempien-Otero A, Sesti C, Du L, Jaffe M, Dichek HL, Pennington CJ, Edwards DR, Nieves-Cintrón M, Minter D, Preusch M, Hu JH, Marie JC, Dichek DA.

Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1251-7. doi: 10.1161/ATVBAHA.109.186593. Epub 2009 Mar 26.


Caloric restriction reverses high-fat diet-induced endothelial dysfunction and vascular superoxide production in C57Bl/6 mice.

Ketonen J, Pilvi T, Mervaala E.

Heart Vessels. 2010 May;25(3):254-62. doi: 10.1007/s00380-009-1182-x. Epub 2010 May 29.


Effects of dietary sodium on reactive oxygen species formation and endothelial dysfunction in low-density lipoprotein receptor-deficient mice on high-fat diet.

Ketonen J, Mervaala E.

Heart Vessels. 2008 Nov;23(6):420-9. doi: 10.1007/s00380-008-1066-5. Epub 2008 Nov 27.


Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction.

Loke WM, Proudfoot JM, Hodgson JM, McKinley AJ, Hime N, Magat M, Stocker R, Croft KD.

Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):749-57. doi: 10.1161/ATVBAHA.109.199687. Epub 2010 Jan 21.


Mechanism of endothelial dysfunction in apolipoprotein E-deficient mice.

d'Uscio LV, Baker TA, Mantilla CB, Smith L, Weiler D, Sieck GC, Katusic ZS.

Arterioscler Thromb Vasc Biol. 2001 Jun;21(6):1017-22.

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