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20506224,12858435,19714586,12571844,19479878,10529123,16200580,10728756,19116915,15593217,19959639,16265694,17265485,23817999,17032244,9485089,11229457,19182257,21968544,10902766,17426140,10813277,9751101,15248214,11465708,18775867,17899549,23666827,11212162,17393408,14613271,26608464,15885642,12858466,15374847,10446857,11069062,19790074,15077296,18412315,11263770,18759269,19644886,20435930,20007590,17530710,17195212,12428227,17045846,10323453,12632414,16126211,8856610,8609431,17323353,12847680,10524679,11196512,1373738,22275154,21116786,21739421,11224527,21905017,21586441,20662068,17009234,20496421,21798287,20498218,21041733,22736176,12746897,24504805,15484188,19248109,25303734,21792838,17392348,24757143,15353579,20506288,24623505,20493562,21268005,17942634,17142787,16278812,21885501,24244022,17612407,21268010,19713442,21469939,22275266,19180491,20936988,21618462,22213107,21965585,19905953,15743469,22819243,21532055,20079789,21953607,28245522,25132679,23280308,32007797,15681827,21953583,23055095,24287514,22674011,22002013,19950291,17182110,29961175,7536415,20548035,23157225,12569162,26213210,25433812,21752471,22691359,22131069,25917106,20349059,22730375,6602856,21159825,1472123,22686732,12651614,35222687,25319955,11083275,20035333,17606978,27851983,15459815,24819400,20722022,23740233,20617899,25833812,21120997,22614825,26751012,17412283,22147632,21739426,12847138,15987490,21514322,23436223,7612044,19543053,20511609,22623332,33201766,33069765,14724428,24241034,23328939,28273363,20181277,23777533,17629517,24470346,21280000,23045162,22231660,23494522,21305500,20506326,24504799,24286358,9764613,10857782,20617529,35129860,24686780,22605541,9300723,21284685,25779027,21225684,16277676,25707877,17726036,31377797,30486874,11109610,17673151,8189099,25792524,17603844,20654699,24838610,23326410,20139271,16388488,24907345,23982886,23632195,23973734,28109308,27342824,21702024,21441014,15837746,17469112,18710567,10812492,15059274,25219368,23065315,21276005,26178284,8546721,16227150,25370956,21442435,9067521,26473405,15301240,21538348,9410920,8624619,26683997,19136305,18590109,28673326,31702035,21469086,12847137,20732650,17328050,31661005,20005897,19435720,23165424,21905879,20191119,23505234,24764451,21080925,20347491,8639182,25435301,22294635,21370936,20381020,8574962,20175883,25261692,9255108,17721918,29489833,31455659,23490466,21195737,22185348,21890656,1706407,16734146,18975332,26147876,27550416,15743468,15022325,20722034,21388353,16542376,20485848,1282007,17911478,19160960,8702434,22447882,15045525,27036883,20225285,21690378,24483119,33779060,11953970,30944034,10886401,12228167,17223651,30554495,26701127,27731365,25847598,9691097,20738854,23398844,28900117,24574225,26152200,22691272,11261813,29257239,34435471,25955571,24016860,24932813,19824913,27823968,8838505,8318038,19116908,18292234,34844926,32499775,7575719,1376652,24065812,22127701,28791012,28320444,11839562,28314223,22586171,20039434,8670592,30093899,23643672,23319740,20483047,7526869,32990025,23447654,8546722,8546719,18566376,24286220,26315300,26097058,21474483,2212003,29626269,30429089,26225917,23633118,30327652,2259896,1729286,27729062,24703062,21567381,21933391,29880013,10759780,30383451,21415051,11549672,19457448,27250804,22392632,24140642,17597384,7657832,21515993,8471533,26017221,22768996,11465704,12632417,28165872,18268348,36270740,7503950,9683554,9153554,15557198,24727939,21885519,8921439,28401953,28392572,22127695,29648684,9603460,31519956,31881419,8808638,22768242,30824383,36537046,22903258,22825627,1836278,15312124,15895888,20131240,7955530,15312407,3266949,11178123,21816017,21446887,15262242,6216579,26711868,27836015,8128913,22777994,24465901,22155198,20939892,20735439,24299175,20565717,7538487,35659346,22179929,2479387,27197661,1376121,9067522,21627981,26554018,24585544,11932780,3263133,33864023,2124531,34497850,24062057,30412852,20653631,15144128,29112182,1657008,21482536,28866647,21141568,24620998,37138547,15579451,25138129,25565644,31537249,11160188,12639998,24813051,34480835,9324019,29136759,14634133,37075620,11072594,34220809,20840794,17304234,1375299,1374550,27741237,15693006,21737801,36936967,24881106,18759291,25339644,20517889,12417057,20852924,20105279,19759858,32900814,12875993,33688303,28082047,16709864,23818173,36511897,29720240,26540618,26980579,24252037,22406293,27165180,18072970,21238451,17056575,27411480,18981087,21723351,16277671,31655341,16751383,6520491,8651984,27863512,21091911,18205004,23580143,19580788,34459110,21982785,1707459,10381490,19170375,23341540,31987855,16864790,19213744,36300114,8774162,15736039,26104678,25422506,27465842,3493780,6983710,7945467,3015786,8625516,3486811,32959594,8741695,26702052,26350255,15875667,26183035,30140263,33038063,6261781,24725539,19099567,23028973,2075371,26585362,30508140,11786429,26724776,23661793,22549100,33148884,19473996,25381389,9159532,9844773,23508298,1719988,22917707,16598819,17195207,31883829,19497113,24764267,25983292,33823532,33256735,25962385,21078714,25277651,26176566,213219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The programmed death 1/programmed death ligand 1 inhibitory pathway is up-regulated in rheumatoid synovium and regulates peripheral T cell responses in human and murine arthritis.

Raptopoulou AP, Bertsias G, Makrygiannakis D, Verginis P, Kritikos I, Tzardi M, Klareskog L, Catrina AI, Sidiropoulos P, Boumpas DT. Raptopoulou AP, et al. Arthritis Rheum. 2010 Jul;62(7):1870-80. doi: 10.1002/art.27500. Arthritis Rheum. 2010. PMID: 20506224 Free article.

CD4+ PD-1+ T cells accumulate as unique anergic cells in rheumatoid arthritis synovial fluid.

Hatachi S, Iwai Y, Kawano S, Morinobu S, Kobayashi M, Koshiba M, Saura R, Kurosaka M, Honjo T, Kumagai S. Hatachi S, et al. J Rheumatol. 2003 Jul;30(7):1410-9. J Rheumatol. 2003. PMID: 12858435

Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis.

Hartgring SA, van Roon JA, Wenting-van Wijk M, Jacobs KM, Jahangier ZN, Willis CR, Bijlsma JW, Lafeber FP. Hartgring SA, et al. Arthritis Rheum. 2009 Sep;60(9):2595-605. doi: 10.1002/art.24754. Arthritis Rheum. 2009. PMID: 19714586 Free article.

Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cells.

van Lent PL, Figdor CG, Barrera P, van Ginkel K, Slöetjes A, van den Berg WB, Torensma R. van Lent PL, et al. Arthritis Rheum. 2003 Feb;48(2):360-9. doi: 10.1002/art.10786. Arthritis Rheum. 2003. PMID: 12571844 Free article.

Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis.

Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H. Murakami Y, et al. Arthritis Rheum. 2009 Jun;60(6):1615-23. doi: 10.1002/art.24554. Arthritis Rheum. 2009. PMID: 19479878 Free article.

Synovium infiltrating T cells induce excessive synovial cell function through CD28/B7 pathway in patients with rheumatoid arthritis.

Shimoyama Y, Nagafuchi H, Suzuki N, Ochi T, Sakane T. Shimoyama Y, et al. J Rheumatol. 1999 Oct;26(10):2094-101. J Rheumatol. 1999. PMID: 10529123

Pathogenic role of the CXCL16-CXCR6 pathway in rheumatoid arthritis.

Nanki T, Shimaoka T, Hayashida K, Taniguchi K, Yonehara S, Miyasaka N. Nanki T, et al. Arthritis Rheum. 2005 Oct;52(10):3004-14. doi: 10.1002/art.21301. Arthritis Rheum. 2005. PMID: 16200580 Free article.

Reduced expression of the regulatory CD4+ T cell subset is related to Th1/Th2 balance and disease severity in rheumatoid arthritis.

Yudoh K, Matsuno H, Nakazawa F, Yonezawa T, Kimura T. Yudoh K, et al. Arthritis Rheum. 2000 Mar;43(3):617-27. doi: 10.1002/1529-0131(200003)43:3<617::AID-ANR19>3.0.CO;2-B. Arthritis Rheum. 2000. PMID: 10728756 Free article.

Genetic, immunologic, and immunohistochemical analysis of the programmed death 1/programmed death ligand 1 pathway in human systemic lupus erythematosus.

Bertsias GK, Nakou M, Choulaki C, Raptopoulou A, Papadimitraki E, Goulielmos G, Kritikos H, Sidiropoulos P, Tzardi M, Kardassis D, Mamalaki C, Boumpas DT. Bertsias GK, et al. Arthritis Rheum. 2009 Jan;60(1):207-18. doi: 10.1002/art.24227. Arthritis Rheum. 2009. PMID: 19116915 Free article.

Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma.

Radstake TR, Roelofs MF, Jenniskens YM, Oppers-Walgreen B, van Riel PL, Barrera P, Joosten LA, van den Berg WB. Radstake TR, et al. Arthritis Rheum. 2004 Dec;50(12):3856-65. doi: 10.1002/art.20678. Arthritis Rheum. 2004. PMID: 15593217 Free article.

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