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Distinct roles of cytochrome P450 reductase in mitomycin C redox cycling and cytotoxicity.

Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD.

Mol Cancer Ther. 2010 Jun;9(6):1852-63. doi: 10.1158/1535-7163.MCT-09-1098. Epub 2010 May 25.


Redox cycling and increased oxygen utilization contribute to diquat-induced oxidative stress and cytotoxicity in Chinese hamster ovary cells overexpressing NADPH-cytochrome P450 reductase.

Fussell KC, Udasin RG, Gray JP, Mishin V, Smith PJ, Heck DE, Laskin JD.

Free Radic Biol Med. 2011 Apr 1;50(7):874-82. doi: 10.1016/j.freeradbiomed.2010.12.035. Epub 2011 Jan 4.


Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity.

Wang Y, Gray JP, Mishin V, Heck DE, Laskin DL, Laskin JD.

Free Radic Biol Med. 2008 Mar 15;44(6):1169-79. doi: 10.1016/j.freeradbiomed.2007.12.013. Epub 2007 Dec 23.


Decreased NADPH:cytochrome P-450 reductase activity and impaired drug activation in a mammalian cell line resistant to mitomycin C under aerobic but not hypoxic conditions.

Hoban PR, Walton MI, Robson CN, Godden J, Stratford IJ, Workman P, Harris AL, Hickson ID.

Cancer Res. 1990 Aug 1;50(15):4692-7.


Redox cycling of resorufin catalyzed by rat liver microsomal NADPH-cytochrome P450 reductase.

Dutton DR, Reed GA, Parkinson A.

Arch Biochem Biophys. 1989 Feb 1;268(2):605-16.


Genetic variation of human cytochrome p450 reductase as a potential biomarker for mitomycin C-induced cytotoxicity.

Wang SL, Han JF, He XY, Wang XR, Hong JY.

Drug Metab Dispos. 2007 Jan;35(1):176-9. Epub 2006 Oct 24.


Role of NADPH:cytochrome c reductase and DT-diaphorase in the biotransformation of mitomycin C1.

Keyes SR, Fracasso PM, Heimbrook DC, Rockwell S, Sligar SG, Sartorelli AC.

Cancer Res. 1984 Dec;44(12 Pt 1):5638-43.


The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes.

Goeptar AR, te Koppele JM, Glatt HR, Groot EJ, Seidel A, Barrenscheen M, Wölfel C, Doehmer J, Vermeulen NP.

Chem Biol Interact. 1995 Jul 14;97(2):149-68.


Human recombinant cytochrome P450 enzymes display distinct hydrogen peroxide generating activities during substrate independent NADPH oxidase reactions.

Mishin V, Heck DE, Laskin DL, Laskin JD.

Toxicol Sci. 2014 Oct;141(2):344-52. doi: 10.1093/toxsci/kfu133. Epub 2014 Jul 24.


In cellulo monitoring of quinone reductase activity and reactive oxygen species production during the redox cycling of 1,2 and 1,4 quinones.

Cassagnes LE, Perio P, Ferry G, Moulharat N, Antoine M, Gayon R, Boutin JA, Nepveu F, Reybier K.

Free Radic Biol Med. 2015 Dec;89:126-34. doi: 10.1016/j.freeradbiomed.2015.07.150. Epub 2015 Sep 18.


Nuclear localization of NADPH:cytochrome c (P450) reductase enhances the cytotoxicity of mitomycin C to Chinese hamster ovary cells.

Seow HA, Belcourt MF, Penketh PG, Hodnick WF, Tomasz M, Rockwell S, Sartorelli AC.

Mol Pharmacol. 2005 Feb;67(2):417-23. Epub 2004 Nov 16.


Viral delivery of P450 reductase recapitulates the ability of constitutive overexpression of reductase enzymes to potentiate the activity of mitomycin C in human breast cancer xenografts.

Cowen RL, Patterson AV, Telfer BA, Airley RE, Hobbs S, Phillips RM, Jaffar M, Stratford IJ, Williams KJ.

Mol Cancer Ther. 2003 Sep;2(9):901-9.


Roles of DNA repair and reductase activity in the cytotoxicity of the hypoxia-activated dinitrobenzamide mustard PR-104A.

Gu Y, Patterson AV, Atwell GJ, Chernikova SB, Brown JM, Thompson LH, Wilson WR.

Mol Cancer Ther. 2009 Jun;8(6):1714-23. doi: 10.1158/1535-7163.MCT-08-1209. Epub 2009 Jun 9.


Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells.

Baumann RP, Hodnick WF, Seow HA, Belcourt MF, Rockwell S, Sherman DH, Sartorelli AC.

Cancer Res. 2001 Nov 1;61(21):7770-6.

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