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Items: 1 to 20 of 105

1.

Endothelial expression of human cytochrome P450 epoxygenases lowers blood pressure and attenuates hypertension-induced renal injury in mice.

Lee CR, Imig JD, Edin ML, Foley J, DeGraff LM, Bradbury JA, Graves JP, Lih FB, Clark J, Myers P, Perrow AL, Lepp AN, Kannon MA, Ronnekleiv OK, Alkayed NJ, Falck JR, Tomer KB, Zeldin DC.

FASEB J. 2010 Oct;24(10):3770-81. doi: 10.1096/fj.10-160119. Epub 2010 May 21.

2.

Endothelial expression of human cytochrome P450 epoxygenase CYP2C8 increases susceptibility to ischemia-reperfusion injury in isolated mouse heart.

Edin ML, Wang Z, Bradbury JA, Graves JP, Lih FB, DeGraff LM, Foley JF, Torphy R, Ronnekleiv OK, Tomer KB, Lee CR, Zeldin DC.

FASEB J. 2011 Oct;25(10):3436-47. doi: 10.1096/fj.11-188300. Epub 2011 Jun 22.

3.

Endothelial CYP epoxygenase overexpression and soluble epoxide hydrolase disruption attenuate acute vascular inflammatory responses in mice.

Deng Y, Edin ML, Theken KN, Schuck RN, Flake GP, Kannon MA, DeGraff LM, Lih FB, Foley J, Bradbury JA, Graves JP, Tomer KB, Falck JR, Zeldin DC, Lee CR.

FASEB J. 2011 Feb;25(2):703-13. doi: 10.1096/fj.10-171488. Epub 2010 Nov 8.

4.

Sex- and isoform-specific mechanism of neuroprotection by transgenic expression of P450 epoxygenase in vascular endothelium.

Jia J, Davis CM, Zhang W, Edin ML, Jouihan S, Jia T, Bradbury JA, Graves JP, DeGraff LM, Lee CR, Ronnekleiv O, Wang R, Xu Y, Zeldin DC, Alkayed NJ.

Exp Neurol. 2016 May;279:75-85. doi: 10.1016/j.expneurol.2016.02.016. Epub 2016 Feb 20.

5.

CYP2J2 overexpression attenuates nonalcoholic fatty liver disease induced by high-fat diet in mice.

Chen G, Xu R, Zhang S, Wang Y, Wang P, Edin ML, Zeldin DC, Wang DW.

Am J Physiol Endocrinol Metab. 2015 Jan 15;308(2):E97-E110. doi: 10.1152/ajpendo.00366.2014. Epub 2014 Nov 11.

6.

Overexpression of cytochrome P450 epoxygenases prevents development of hypertension in spontaneously hypertensive rats by enhancing atrial natriuretic peptide.

Xiao B, Li X, Yan J, Yu X, Yang G, Xiao X, Voltz JW, Zeldin DC, Wang DW.

J Pharmacol Exp Ther. 2010 Sep 1;334(3):784-94. doi: 10.1124/jpet.110.167510. Epub 2010 May 25.

7.

Cardiac-specific overexpression of CYP2J2 attenuates diabetic cardiomyopathy in male streptozotocin-induced diabetic mice.

Ma B, Xiong X, Chen C, Li H, Xu X, Li X, Li R, Chen G, Dackor RT, Zeldin DC, Wang DW.

Endocrinology. 2013 Aug;154(8):2843-56. doi: 10.1210/en.2012-2166. Epub 2013 May 21.

8.

CYP2J2 targeting to endothelial cells attenuates adiposity and vascular dysfunction in mice fed a high-fat diet by reprogramming adipocyte phenotype.

Abraham NG, Sodhi K, Silvis AM, Vanella L, Favero G, Rezzani R, Lee C, Zeldin DC, Schwartzman ML.

Hypertension. 2014 Dec;64(6):1352-61. doi: 10.1161/HYPERTENSIONAHA.114.03884. Epub 2014 Sep 22.

9.

Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage.

Henke N, Schmidt-Ullrich R, Dechend R, Park JK, Qadri F, Wellner M, Obst M, Gross V, Dietz R, Luft FC, Scheidereit C, Muller DN.

Circ Res. 2007 Aug 3;101(3):268-76. Epub 2007 Jun 21.

10.

Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells.

Yang B, Graham L, Dikalov S, Mason RP, Falck JR, Liao JK, Zeldin DC.

Mol Pharmacol. 2001 Aug;60(2):310-20.

11.

The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases.

Xu X, Zhang XA, Wang DW.

Adv Drug Deliv Rev. 2011 Jul 18;63(8):597-609. doi: 10.1016/j.addr.2011.03.006. Epub 2011 Apr 6. Review.

PMID:
21477627
12.

Influence of inflammation on cardiovascular protective effects of cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids.

Shahabi P, Siest G, Visvikis-siest S.

Drug Metab Rev. 2014 Feb;46(1):33-56. doi: 10.3109/03602532.2013.837916. Epub 2013 Sep 16. Review.

PMID:
24040964
13.

Role of cytochrome P450 epoxygenase in regulating renal membrane transport and hypertension.

Capdevila J, Wang W.

Curr Opin Nephrol Hypertens. 2013 Mar;22(2):163-9. doi: 10.1097/MNH.0b013e32835d911e. Review.

14.

Cytochrome P450 epoxygenase CYP2J2 attenuates nephropathy in streptozotocin-induced diabetic mice.

Chen G, Wang P, Zhao G, Xu G, Gruzdev A, Zeldin DC, Wang DW.

Prostaglandins Other Lipid Mediat. 2011 Nov;96(1-4):63-71. doi: 10.1016/j.prostaglandins.2011.06.009. Epub 2011 Jun 30.

15.

Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms.

Lu T, Ye D, Wang X, Seubert JM, Graves JP, Bradbury JA, Zeldin DC, Lee HC.

J Physiol. 2006 Sep 1;575(Pt 2):627-44. Epub 2006 Jun 22.

16.

Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation.

Loot AE, Popp R, Fisslthaler B, Vriens J, Nilius B, Fleming I.

Cardiovasc Res. 2008 Dec 1;80(3):445-52. doi: 10.1093/cvr/cvn207. Epub 2008 Aug 5.

PMID:
18682435
17.

CYP epoxygenase derived EETs: from cardiovascular protection to human cancer therapy.

Chen C, Wang DW.

Curr Top Med Chem. 2013;13(12):1454-69. Review.

PMID:
23688135
18.

Roles of the epoxygenase CYP2J2 in the endothelium.

Askari A, Thomson SJ, Edin ML, Zeldin DC, Bishop-Bailey D.

Prostaglandins Other Lipid Mediat. 2013 Dec;107:56-63. doi: 10.1016/j.prostaglandins.2013.02.003. Epub 2013 Mar 6. Review.

19.

Vascular endothelial overexpression of human CYP2J2 (Tie2-CYP2J2 Tr) modulates cardiac oxylipin profiles and enhances coronary reactive hyperemia in mice.

Hanif A, Edin ML, Zeldin DC, Morisseau C, Falck JR, Nayeem MA.

PLoS One. 2017 Mar 22;12(3):e0174137. doi: 10.1371/journal.pone.0174137. eCollection 2017.

20.

Increasing or stabilizing renal epoxyeicosatrienoic acid production attenuates abnormal renal function and hypertension in obese rats.

Huang H, Morisseau C, Wang J, Yang T, Falck JR, Hammock BD, Wang MH.

Am J Physiol Renal Physiol. 2007 Jul;293(1):F342-9. Epub 2007 Apr 18.

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