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Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice.

Freigang S, Zadorozhny V, McKinney MK, Krebs P, Herro R, Pawlak J, Kain L, Schrantz N, Masuda K, Liu Y, Savage PB, Bendelac A, Cravatt BF, Teyton L.

J Clin Invest. 2010 Jun;120(6):1873-84. doi: 10.1172/JCI40451. Epub 2010 May 17.


Scavenger receptors target glycolipids for natural killer T cell activation.

Freigang S, Landais E, Zadorozhny V, Kain L, Yoshida K, Liu Y, Deng S, Palinski W, Savage PB, Bendelac A, Teyton L.

J Clin Invest. 2012 Nov;122(11):3943-54. doi: 10.1172/JCI62267. Epub 2012 Oct 15.


In contrast to other species, α-Galactosylceramide (α-GalCer) is not an immunostimulatory NKT cell agonist in horses.

Dossa RG, Alperin DC, Garzon D, Mealey RH, Brown WC, Jervis PJ, Besra GS, Cox LR, Hines SA.

Dev Comp Immunol. 2015 Mar;49(1):49-58. doi: 10.1016/j.dci.2014.11.005. Epub 2014 Nov 10.


Quantitative and qualitative differences in the in vivo response of NKT cells to distinct alpha- and beta-anomeric glycolipids.

Parekh VV, Singh AK, Wilson MT, Olivares-Villagómez D, Bezbradica JS, Inazawa H, Ehara H, Sakai T, Serizawa I, Wu L, Wang CR, Joyce S, Van Kaer L.

J Immunol. 2004 Sep 15;173(6):3693-706.


Dissociation of NKT stimulation, cytokine induction, and NK activation in vivo by the use of distinct TCR-binding ceramides.

Ortaldo JR, Young HA, Winkler-Pickett RT, Bere EW Jr, Murphy WJ, Wiltrout RH.

J Immunol. 2004 Jan 15;172(2):943-53.


Crystal structures of bovine CD1d reveal altered αGalCer presentation and a restricted A' pocket unable to bind long-chain glycolipids.

Wang J, Guillaume J, Pauwels N, Van Calenbergh S, Van Rhijn I, Zajonc DM.

PLoS One. 2012;7(10):e47989. doi: 10.1371/journal.pone.0047989. Epub 2012 Oct 23.


The interface between innate and acquired immunity: glycolipid antigen presentation by CD1d-expressing dendritic cells to NKT cells induces the differentiation of antigen-specific cytotoxic T lymphocytes.

Nishimura T, Kitamura H, Iwakabe K, Yahata T, Ohta A, Sato M, Takeda K, Okumura K, Van Kaer L, Kawano T, Taniguchi M, Nakui M, Sekimoto M, Koda T.

Int Immunol. 2000 Jul;12(7):987-94.


Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells.

Metelitsa LS, Naidenko OV, Kant A, Wu HW, Loza MJ, Perussia B, Kronenberg M, Seeger RC.

J Immunol. 2001 Sep 15;167(6):3114-22.


Application of natural killer T cells in antitumor immunotherapy.

Hong C, Park SH.

Crit Rev Immunol. 2007;27(6):511-25. Review.


Mechanisms for glycolipid antigen-driven cytokine polarization by Valpha14i NKT cells.

Sullivan BA, Nagarajan NA, Wingender G, Wang J, Scott I, Tsuji M, Franck RW, Porcelli SA, Zajonc DM, Kronenberg M.

J Immunol. 2010 Jan 1;184(1):141-53. doi: 10.4049/jimmunol.0902880. Epub 2009 Nov 30.


Interplay between carbohydrate and lipid in recognition of glycolipid antigens by natural killer T cells.

Pei B, Vela JL, Zajonc D, Kronenberg M.

Ann N Y Acad Sci. 2012 Apr;1253:68-79. doi: 10.1111/j.1749-6632.2011.06435.x. Epub 2012 Feb 21. Review.


Glycolipids injected into the skin are presented to NKT cells in the draining lymph node independently of migratory skin dendritic cells.

Tripp CH, Sparber F, Hermans IF, Romani N, Stoitzner P.

J Immunol. 2009 Jun 15;182(12):7644-54. doi: 10.4049/jimmunol.0900134.


NKT cell activation by local α-galactosylceramide administration decreases susceptibility to HSV-2 infection.

Iversen MB, Jensen SK, Hansen AL, Winther H, Issazadeh-Navikas S, Reinert LS, Holm CK.

Immunobiology. 2015 Jun;220(6):762-8. doi: 10.1016/j.imbio.2014.12.019. Epub 2015 Jan 21.


Kinetics and cellular site of glycolipid loading control the outcome of natural killer T cell activation.

Im JS, Arora P, Bricard G, Molano A, Venkataswamy MM, Baine I, Jerud ES, Goldberg MF, Baena A, Yu KO, Ndonye RM, Howell AR, Yuan W, Cresswell P, Chang YT, Illarionov PA, Besra GS, Porcelli SA.

Immunity. 2009 Jun 19;30(6):888-98. doi: 10.1016/j.immuni.2009.03.022.


In vivo identification of glycolipid antigen-specific T cells using fluorescent CD1d tetramers.

Benlagha K, Weiss A, Beavis A, Teyton L, Bendelac A.

J Exp Med. 2000 Jun 5;191(11):1895-903.


NKT-cell help to B lymphocytes can occur independently of cognate interaction.

Tonti E, Galli G, Malzone C, Abrignani S, Casorati G, Dellabona P.

Blood. 2009 Jan 8;113(2):370-6. doi: 10.1182/blood-2008-06-166249. Epub 2008 Oct 2.


Glycolipid activators of invariant NKT cells as vaccine adjuvants.

Kharkwal SS, Arora P, Porcelli SA.

Immunogenetics. 2016 Aug;68(8):597-610. doi: 10.1007/s00251-016-0925-y. Epub 2016 Jul 5. Review.


Dendritic cell internalization of α-galactosylceramide from CD8 T cells induces potent antitumor CD8 T-cell responses.

Choi DH, Kim KS, Yang SH, Chung DH, Song B, Sprent J, Cho JH, Sung YC.

Cancer Res. 2011 Dec 15;71(24):7442-51. doi: 10.1158/0008-5472.CAN-11-1459. Epub 2011 Oct 25.


Optimizing NKT cell ligands as vaccine adjuvants.

Carreño LJ, Kharkwal SS, Porcelli SA.

Immunotherapy. 2014;6(3):309-20. doi: 10.2217/imt.13.175. Review.


Colocalization of a CD1d-Binding Glycolipid with a Radiation-Attenuated Sporozoite Vaccine in Lymph Node-Resident Dendritic Cells for a Robust Adjuvant Effect.

Li X, Kawamura A, Andrews CD, Miller JL, Wu D, Tsao T, Zhang M, Oren D, Padte NN, Porcelli SA, Wong CH, Kappe SH, Ho DD, Tsuji M.

J Immunol. 2015 Sep 15;195(6):2710-21. doi: 10.4049/jimmunol.1403017. Epub 2015 Aug 7.

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