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Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.

Li B, Hu Q, Wang H, Man N, Ren H, Wen L, Nukina N, Fei E, Wang G.

Cell Death Differ. 2010 Nov;17(11):1773-84. doi: 10.1038/cdd.2010.55. Epub 2010 May 14.


The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation.

Hu Q, Li B, Xu R, Chen D, Mu C, Fei E, Wang G.

Sci Signal. 2012 Aug 21;5(238):ra61. doi: 10.1126/scisignal.2002946.


Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy.

Cilenti L, Ambivero CT, Ward N, Alnemri ES, Germain D, Zervos AS.

Biochim Biophys Acta. 2014 Jul;1843(7):1295-307. doi: 10.1016/j.bbamcr.2014.03.027. Epub 2014 Apr 5.


The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.

Xu R, Hu Q, Ma Q, Liu C, Wang G.

Cell Death Dis. 2014 Aug 14;5:e1373. doi: 10.1038/cddis.2014.328.


Omi / HtrA2 is relevant to the selective vulnerability of striatal neurons in Huntington's disease.

Inagaki R, Tagawa K, Qi ML, Enokido Y, Ito H, Tamura T, Shimizu S, Oyanagi K, Arai N, Kanazawa I, Wanker EE, Okazawa H.

Eur J Neurosci. 2008 Jul;28(1):30-40. doi: 10.1111/j.1460-9568.2008.06323.x.


A novel role for the mitochondrial HTRA2/OMI protease in aging.

Kang S, Fernandes-Alnemri T, Alnemri ES.

Autophagy. 2013 Mar;9(3):420-1. doi: 10.4161/auto.22920. Epub 2012 Dec 14.


Regulation of HAX-1 anti-apoptotic protein by Omi/HtrA2 protease during cell death.

Cilenti L, Soundarapandian MM, Kyriazis GA, Stratico V, Singh S, Gupta S, Bonventre JV, Alnemri ES, Zervos AS.

J Biol Chem. 2004 Nov 26;279(48):50295-301. Epub 2004 Sep 15.


Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.

Kieper N, Holmström KM, Ciceri D, Fiesel FC, Wolburg H, Ziviani E, Whitworth AJ, Martins LM, Kahle PJ, Krüger R.

Exp Cell Res. 2010 Apr 15;316(7):1213-24. doi: 10.1016/j.yexcr.2010.01.005. Epub 2010 Jan 11.


Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria.

Mandel H, Saita S, Edvardson S, Jalas C, Shaag A, Goldsher D, Vlodavsky E, Langer T, Elpeleg O.

J Med Genet. 2016 Oct;53(10):690-6. doi: 10.1136/jmedgenet-2016-103922. Epub 2016 May 12.


Accumulation of HtrA2/Omi in neuronal and glial inclusions in brains with alpha-synucleinopathies.

Kawamoto Y, Kobayashi Y, Suzuki Y, Inoue H, Tomimoto H, Akiguchi I, Budka H, Martins LM, Downward J, Takahashi R.

J Neuropathol Exp Neurol. 2008 Oct;67(10):984-93. doi: 10.1097/NEN.0b013e31818809f4.


Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212.

Yang L, Sun M, Sun XM, Cheng GZ, Nicosia SV, Cheng JQ.

J Biol Chem. 2007 Apr 13;282(15):10981-7. Epub 2007 Feb 20. Retraction in: J Biol Chem. 2016 Oct 21;291(43):22843.


Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration.

Ding X, Patel M, Shen D, Herzlich AA, Cao X, Villasmil R, Klupsch K, Tuo J, Downward J, Chan CC.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4957-66. doi: 10.1167/iovs.09-3381. Epub 2009 May 14.


Variations in the protein level of Omi/HtrA2 in the heart of aged rats may contribute to the increased susceptibility of cardiomyocytes to ischemia/reperfusion injury and cell death : Omi/HtrA2 and aged heart injury.

Wang K, Zhang J, Liu J, Tian J, Wu Y, Wang X, Quan L, Xu H, Wang W, Liu H.

Age (Dordr). 2013 Jun;35(3):733-46. doi: 10.1007/s11357-012-9406-x. Epub 2012 Apr 26.


Modulation of the Omi/HtrA2 signaling pathway after transient focal cerebral ischemia in mouse brains that overexpress SOD1.

Saito A, Hayashi T, Okuno S, Nishi T, Chan PH.

Brain Res Mol Brain Res. 2004 Aug 23;127(1-2):89-95.


Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.

Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P, Abuin A, Grau E, Geppert M, Livi GP, Creasy CL, Martin A, Hargreaves I, Heales SJ, Okada H, Brandner S, Schulz JB, Mak T, Downward J.

Mol Cell Biol. 2004 Nov;24(22):9848-62.


THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.

Balakrishnan MP, Cilenti L, Mashak Z, Popat P, Alnemri ES, Zervos AS.

Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H643-53. doi: 10.1152/ajpheart.00234.2009. Epub 2009 Jun 5.


HtrA2/Omi, a sheep in wolf's clothing.

Vaux DL, Silke J.

Cell. 2003 Oct 31;115(3):251-3.


Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2.

Srinivasula SM, Gupta S, Datta P, Zhang Z, Hegde R, Cheong N, Fernandes-Alnemri T, Alnemri ES.

J Biol Chem. 2003 Aug 22;278(34):31469-72. Epub 2003 Jun 30.


The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal.

Vande Walle L, Wirawan E, Lamkanfi M, Festjens N, Verspurten J, Saelens X, Vanden Berghe T, Vandenabeele P.

Cell Res. 2010 Apr;20(4):421-33. doi: 10.1038/cr.2010.18. Epub 2010 Feb 2.


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