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A high-throughput respirometric assay for mitochondrial biogenesis and toxicity.

Beeson CC, Beeson GC, Schnellmann RG.

Anal Biochem. 2010 Sep 1;404(1):75-81. doi: 10.1016/j.ab.2010.04.040. Epub 2010 May 11.


The β2-adrenoceptor agonist formoterol stimulates mitochondrial biogenesis.

Wills LP, Trager RE, Beeson GC, Lindsey CC, Peterson YK, Beeson CC, Schnellmann RG.

J Pharmacol Exp Ther. 2012 Jul;342(1):106-18. doi: 10.1124/jpet.112.191528. Epub 2012 Apr 6.


High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury.

Wills LP, Beeson GC, Trager RE, Lindsey CC, Beeson CC, Peterson YK, Schnellmann RG.

Toxicol Appl Pharmacol. 2013 Oct 15;272(2):490-502. doi: 10.1016/j.taap.2013.06.014. Epub 2013 Jun 26.


SRT1720 induces mitochondrial biogenesis and rescues mitochondrial function after oxidant injury in renal proximal tubule cells.

Funk JA, Odejinmi S, Schnellmann RG.

J Pharmacol Exp Ther. 2010 May;333(2):593-601. doi: 10.1124/jpet.109.161992. Epub 2010 Jan 26.


Seahorse Xfe 24 Extracellular Flux Analyzer-Based Analysis of Cellular Respiration in Caenorhabditis elegans.

Luz AL, Smith LL, Rooney JP, Meyer JN.

Curr Protoc Toxicol. 2015 Nov 2;66:25.7.1-15. doi: 10.1002/0471140856.tx2507s66.


5-hydroxytryptamine receptor stimulation of mitochondrial biogenesis.

Rasbach KA, Funk JA, Jayavelu T, Green PT, Schnellmann RG.

J Pharmacol Exp Ther. 2010 Feb;332(2):632-9. doi: 10.1124/jpet.109.159947. Epub 2009 Oct 29.


Mitochondrial injury: an early event in cisplatin toxicity to renal proximal tubules.

Brady HR, Kone BC, Stromski ME, Zeidel ML, Giebisch G, Gullans SR.

Am J Physiol. 1990 May;258(5 Pt 2):F1181-7.


γ-Tocotrienol protects against mitochondrial dysfunction and renal cell death.

Nowak G, Bakajsova D, Hayes C, Hauer-Jensen M, Compadre CM.

J Pharmacol Exp Ther. 2012 Feb;340(2):330-8. doi: 10.1124/jpet.111.186882. Epub 2011 Oct 31.


Assessment of ToxCast Phase II for Mitochondrial Liabilities Using a High-Throughput Respirometric Assay.

Wills LP, Beeson GC, Hoover DB, Schnellmann RG, Beeson CC.

Toxicol Sci. 2015 Aug;146(2):226-34. doi: 10.1093/toxsci/kfv085. Epub 2015 Apr 28.


Akt activation improves oxidative phosphorylation in renal proximal tubular cells following nephrotoxicant injury.

Shaik ZP, Fifer EK, Nowak G.

Am J Physiol Renal Physiol. 2008 Feb;294(2):F423-32. Epub 2007 Dec 12.


Quantitative analysis of mitochondrial morphology and membrane potential in living cells using high-content imaging, machine learning, and morphological binning.

Leonard AP, Cameron RB, Speiser JL, Wolf BJ, Peterson YK, Schnellmann RG, Beeson CC, Rohrer B.

Biochim Biophys Acta. 2015 Feb;1853(2):348-60. doi: 10.1016/j.bbamcr.2014.11.002. Epub 2014 Nov 13.


Protein kinase C-α activation promotes recovery of mitochondrial function and cell survival following oxidant injury in renal cells.

Nowak G, Bakajsova D.

Am J Physiol Renal Physiol. 2012 Aug 15;303(4):F515-26. doi: 10.1152/ajprenal.00072.2012. Epub 2012 Jun 6.


Succinate ameliorates energy deficits and prevents dysfunction of complex I in injured renal proximal tubular cells.

Nowak G, Clifton GL, Bakajsova D.

J Pharmacol Exp Ther. 2008 Mar;324(3):1155-62. Epub 2007 Nov 30.


Cisplatin-induced nephrotoxicity in porcine proximal tubular cells: mitochondrial dysfunction by inhibition of complexes I to IV of the respiratory chain.

Kruidering M, Van de Water B, de Heer E, Mulder GJ, Nagelkerke JF.

J Pharmacol Exp Ther. 1997 Feb;280(2):638-49.


Isoflavones promote mitochondrial biogenesis.

Rasbach KA, Schnellmann RG.

J Pharmacol Exp Ther. 2008 May;325(2):536-43. doi: 10.1124/jpet.107.134882. Epub 2008 Feb 11.


Respiration in adipocytes is inhibited by reactive oxygen species.

Wang T, Si Y, Shirihai OS, Si H, Schultz V, Corkey RF, Hu L, Deeney JT, Guo W, Corkey BE.

Obesity (Silver Spring). 2010 Aug;18(8):1493-502. doi: 10.1038/oby.2009.456. Epub 2009 Dec 24.


Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways.

Cummings BS, Schnellmann RG.

J Pharmacol Exp Ther. 2002 Jul;302(1):8-17.


Protein kinase C-epsilon activation induces mitochondrial dysfunction and fragmentation in renal proximal tubules.

Nowak G, Bakajsova D, Samarel AM.

Am J Physiol Renal Physiol. 2011 Jul;301(1):F197-208. doi: 10.1152/ajprenal.00364.2010. Epub 2011 Feb 2.

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