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Items: 1 to 20 of 113


Rem GTPase interacts with the proximal CaV1.2 C-terminus and modulates calcium-dependent channel inactivation.

Pang C, Crump SM, Jin L, Correll RN, Finlin BS, Satin J, Andres DA.

Channels (Austin). 2010 May-Jun;4(3):192-202. Epub 2010 May 1.


Distinct RGK GTPases differentially use α1- and auxiliary β-binding-dependent mechanisms to inhibit CaV1.2/CaV2.2 channels.

Yang T, Puckerin A, Colecraft HM.

PLoS One. 2012;7(5):e37079. doi: 10.1371/journal.pone.0037079. Epub 2012 May 10.


Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases.

Finlin BS, Crump SM, Satin J, Andres DA.

Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14469-74. Epub 2003 Nov 17.


Molecular mechanisms, and selective pharmacological rescue, of Rem-inhibited CaV1.2 channels in heart.

Xu X, Marx SO, Colecraft HM.

Circ Res. 2010 Sep 3;107(5):620-30. doi: 10.1161/CIRCRESAHA.110.224717. Epub 2010 Jul 8.


Expression of Rem2, an RGK family small GTPase, reduces N-type calcium current without affecting channel surface density.

Chen H, Puhl HL 3rd, Niu SL, Mitchell DC, Ikeda SR.

J Neurosci. 2005 Oct 19;25(42):9762-72.


Differential effects of RGK proteins on L-type channel function in adult mouse skeletal muscle.

Beqollari D, Romberg CF, Meza U, Papadopoulos S, Bannister RA.

Biophys J. 2014 May 6;106(9):1950-7. doi: 10.1016/j.bpj.2014.03.033.


Similar molecular determinants on Rem mediate two distinct modes of inhibition of CaV1.2 channels.

Puckerin AA, Chang DD, Subramanyam P, Colecraft HM.

Channels (Austin). 2016 Sep 2;10(5):379-394. Epub 2016 Apr 26.


RGK GTPase-dependent CaV2.1 Ca2+ channel inhibition is independent of CaVbeta-subunit-induced current potentiation.

Leyris JP, Gondeau C, Charnet A, Delattre C, Rousset M, Cens T, Charnet P.

FASEB J. 2009 Aug;23(8):2627-38. doi: 10.1096/fj.08-122135. Epub 2009 Mar 30.


Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase.

Yang T, Xu X, Kernan T, Wu V, Colecraft HM.

J Physiol. 2010 May 15;588(Pt 10):1665-81. doi: 10.1113/jphysiol.2010.187203. Epub 2010 Mar 22.


L-type calcium channel alpha-subunit and protein kinase inhibitors modulate Rem-mediated regulation of current.

Crump SM, Correll RN, Schroder EA, Lester WC, Finlin BS, Andres DA, Satin J.

Am J Physiol Heart Circ Physiol. 2006 Oct;291(4):H1959-71. Epub 2006 Apr 28.


RGK protein-mediated impairment of slow depolarization- dependent Ca2+ entry into developing myotubes.

Romberg CF, Beqollari D, Meza U, Bannister RA.

Channels (Austin). 2014;8(3):243-8.


RGK small GTP-binding proteins interact with the nucleotide kinase domain of Ca2+-channel beta-subunits via an uncommon effector binding domain.

Béguin P, Ng YJ, Krause C, Mahalakshmi RN, Ng MY, Hunziker W.

J Biol Chem. 2007 Apr 13;282(15):11509-20. Epub 2007 Feb 15.


Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2.

Béguin P, Mahalakshmi RN, Nagashima K, Cher DH, Kuwamura N, Yamada Y, Seino Y, Hunziker W.

Biochem J. 2005 Aug 15;390(Pt 1):67-75. Erratum in: Biochem J. 2005 Nov 1;391(Pt 3):712.


Analysis of the complex between Ca2+ channel beta-subunit and the Rem GTPase.

Finlin BS, Correll RN, Pang C, Crump SM, Satin J, Andres DA.

J Biol Chem. 2006 Aug 18;281(33):23557-66. Epub 2006 Jun 21.


Nuclear sequestration of beta-subunits by Rad and Rem is controlled by 14-3-3 and calmodulin and reveals a novel mechanism for Ca2+ channel regulation.

Béguin P, Mahalakshmi RN, Nagashima K, Cher DH, Ikeda H, Yamada Y, Seino Y, Hunziker W.

J Mol Biol. 2006 Jan 6;355(1):34-46. Epub 2005 Nov 8.


Plasma membrane targeting is essential for Rem-mediated Ca2+ channel inhibition.

Correll RN, Pang C, Finlin BS, Dailey AM, Satin J, Andres DA.

J Biol Chem. 2007 Sep 28;282(39):28431-40. Epub 2007 Aug 7.


Regulation of voltage-dependent calcium channels by RGK proteins.

Yang T, Colecraft HM.

Biochim Biophys Acta. 2013 Jul;1828(7):1644-54. doi: 10.1016/j.bbamem.2012.10.005. Epub 2012 Oct 10. Review.


Nuclear localization of endogenous RGK proteins and modulation of cell shape remodeling by regulated nuclear transport.

Mahalakshmi RN, Ng MY, Guo K, Qi Z, Hunziker W, Béguin P.

Traffic. 2007 Sep;8(9):1164-78. Epub 2007 Jul 1.


Potent inhibition of L-type Ca2+ currents by a Rad variant associated with congestive heart failure.

Meza U, Beqollari D, Romberg CF, Papadopoulos S, Bannister RA.

Biochem Biophys Res Commun. 2013 Sep 20;439(2):270-4. doi: 10.1016/j.bbrc.2013.08.044. Epub 2013 Aug 20.


Functional assessment of three Rem residues identified as critical for interactions with Ca(2+) channel β subunits.

Beqollari D, Romberg CF, Filipova D, Papadopoulos S, Bannister RA.

Pflugers Arch. 2015 Nov;467(11):2299-306. doi: 10.1007/s00424-015-1700-x. Epub 2015 Mar 15.


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